Effects of Glucose Load and Nateglinide Intervention on Endothelial Function and Oxidative Stress

Wang, Leilei; Guo, Lixin; Zhang, Lina; Zhou, Yan; He, Qin; Zhang, Zheng; Wang, Meng

doi:10.1155/2013/849295

Cited by 15 publications

(17 citation statements)

References 27 publications

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“…In contradiction to previous findings in animal and in vitro studies, which found VSM dysfunction mediated by VSM cell proliferation may occur in as little as 6 hours. 20,52 Macrovascular endothelial dysfunction observed during acute hyperglycemia by methods assessing endothelium-dependent vasodilation primarily implicate decreased NO bioavailability as a central mechanism of endothelial dysfunction in healthy and cardiometabolic diseased populations. 69 This may be attributed to acute hyperglycemia increasing oxidative stress and its role in disrupting pathways of NO synthesis.…”

Section: Discussionmentioning

confidence: 99%

“…Fourteen of these articles reported vascular data for multiple subgroups of a given or diverse health status; thus, they were assessed as individual studies. 22,[25][26][27][28]31,37,38,45,52,[56][57][58][59] The main characteristics and clinical data for these studies are shown in Tables 1 and 2, respectively. Three potentially relevant studies were not available for full text reading and thus could not be included.…”

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Acute Hyperglycemia Impairs Vascular Function in Healthy and Cardiometabolic Diseased Subjects

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Montero

Lorenzen

et al. 2015

ATVB

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Objectives-Controversy exists over the effect of acute hyperglycemia on vascular function. In this systematic review, we compared the effect of acute hyperglycemia on endothelial and vascular smooth muscle functions across healthy and cardiometabolic diseased subjects. Approach and Results-A systematic search of MEDLINE, EMBASE, and Web of Science from inception until July 2014 identified articles evaluating endothelial or vascular smooth muscle function during acute hyperglycemia and normoglycemia. Meta-analyses compared the standardized mean difference (SMD) in endothelial and vascular smooth muscle functions between acute hyperglycemia and normoglycemia. Subgroup analyses and metaregression identified sources of heterogeneity. Thirty-nine articles (525 healthy and 540 cardiometabolic subjects) were analyzed. Endothelial function was decreased (39 studies; n=1065; SMD, −1.25; 95% confidence interval, −1.52 to −0.98; P<0.01), whereas vascular smooth muscle function was preserved (6 studies; n=144; SMD, −0.07; 95% confidence interval, −0.30 to 0.16; P=0.55) during acute hyperglycemia compared with normoglycemia. Significant heterogeneity was detected among endothelial function studies (P<0.01). A subgroup analysis revealed that endothelial function was decreased in the macrocirculation (30 studies; n=884; SMD, −1.40; 95% confidence interval, −1.68 to −1.12; P<0.01) but not in the microcirculation (9 studies; n=181; SMD, −0.63; 95% confidence interval, −1.36 to 0.11; P=0.09). Similar results were observed according to health status. Macrovascular endothelial function was inversely associated with age, blood pressure, and low-density lipoprotein cholesterol and was positively associated with the postocclusion interval of vascular assessment. Conclusions-To our knowledge, this is the first systematic review and meta-analysis of its kind. In healthy and diseased subjects, we found evidence for macrovascular but not microvascular endothelial dysfunction during acute hyperglycemia. Loader et al Acute Hyperglycemia Impairs Vascular Function 2061in vitro studies suggest that acute hyperglycemia may also impair VSM function by disrupting VSM cell apoptosis, causing subsequent VSM cell proliferation and desensitization to NO. [19][20][21] However, whether endothelial and VSM functions are transiently impaired during acute hyperglycemia in humans is unclear because of discrepant results. Given this, we conducted a systematic review and meta-analysis of available studies comparing endothelial function alone or in combination with VSM function during acute hyperglycemia in healthy and cardiometabolic diseased individuals. To our knowledge, this represents the first systematic review and meta-analysis to assess the effect of acute hyperglycemia on vascular function. Materials and MethodsMaterials and methods are available in the online-only Data Supplement. Results Study Selection and CharacteristicsA flowchart of study selection is shown in Figure 1. The systematic search resulted in the inclusion of 39 from 394 potential a...

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Section: Discussionmentioning

confidence: 99%

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Acute Hyperglycemia Impairs Vascular Function in Healthy and Cardiometabolic Diseased Subjects

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Montero

Lorenzen

et al. 2015

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“…Among several disorders caused by oxidative stress, diabetes has been named as a major and common one. In fact, a relationship has been established between glucose load reduction and reduction in insulin resistance and oxidative stress in diabetic people (Wang et al, ). Overtime, when the glucose level is poorly controlled, it leads to hyperglycemia which contributes to tissue damage as well as development of micro/macro‐vascular problems and infertility.…”

Section: Introductionmentioning

confidence: 99%

African star apple fruit pulp‐supplemented diet modulates fertility‐related biomolecules in the testis and epididymis of high‐fat diet/streptozotocin‐induced diabetic rats

et al. 2019

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This study evaluated the modulatory effect of African star apple fruit (ASAF) pulp inclusive diet on biomolecules associated with reproductive function in the testis and epididymis of high‐fat diet/streptozotocin‐induced diabetic male rats. The rats were divided into seven groups: control, diabetic control, diabetic rats treated with metformin, diabetic rats served with diet having 5 and 10% ASAF, respectively, and control rats served with diet containing 5%, and 10% ASAF respectively for 14 days. There were noticeable decrease in sperm parameters, reproductive hormone, glycogen, nitric oxide, total thiol, nonprotein thiol levels, and testicular 3β‐ and 17β‐hydroxysteroid dehydrogenase activities and concomitant increase in cholesterol, reactive oxygen species, malondialdehyde levels, and arginase activity compared to the control. Nevertheless, ASAFs reversed all these parameters toward the control levels. Therefore, these findings suggest that ASAF pulp‐supplemented diet might be an active approach in controlling male reproductive dysfunction induced by diabetes. Practical applications The results suggest that ASAF pulp‐supplemented diet might be an active approach in controlling male reproductive dysfunction induced by diabetes through alterations in the levels of blood glucose, glycogen, cholesterol, nitric oxide, reproductive hormones, activities of steroidogenic enzymes, arginase, and sperm characteristics as well as the antioxidant status in the testes and epididymis.

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“…Diabetes is among a number of disorders caused by oxidative stress. In fact there has been an established relationship between the reduction in glucose load and reduction in insulin resistance and oxidative stress in diabetic people (Wang et al, 2013). Poor glucose control over the time (hyperglycemia) causing tissues to damage and produce life-threatening health complications such as micro vascular or macro vascular disease and infertility.…”

Section: Introductionmentioning

confidence: 99%

The anti-oxidant effects of ginger and cinnamon on spermatogenesis dys-function of diabetes rats

Khaki¹,

Hajhosseini²,

Golzar³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Diabetes rats have been linked to reproductive dysfunction and plant medicine has been shown to be effective in its treatment. Antioxidants have distinctive effects on spermatogenesis, sperm biology and oxidative stress, and changes in anti-oxidant capacity are considered to be involved in the pathogenesis of chronic diabetes mellitus. Ginger and cinnamon are strong anti-oxidants and have been shown to reduce oxidative stress in the long-term treatment of streptozotocin (STZ)-induced diabetes in animal models. The present study examined the influence of combined ginger and cinnamon on spermatogenesis in STZ-induced diabetes in male Wistar rats. Materials and Methods: Animals (n = 80) were allocated randomly into eight groups, 10 each: Group 1: Control rats given only 5cc Normal saline (0.9% NaCl) daily;Group2: rats received ginger (100mg/kg/rat) daily; Group 3: rats received cinnamon (75mg/kg) daily; Group 4: rats received ginger and cinnamon, (100mg/kg/rat ginger and 75mg/kg cinnamon) daily; Group 5: Diabetic control rats received only normal saline. Group 6: Diabetic rats received 100mg/kg/day ginger; Group 7: Diabetic rats received 75mg /kg/ day cinnamon; Group 8: Diabetic rats received ginger and cinnamon (100mg/kg/day and 75mg/kg /day). Diabetes was induced with 55 mg/kg, single intra-peritoneal injection of STZ in all groups. At the end of the experiment (56th day), blood samples were taken for determination of testosterone, LH,FSH, total anti-oxidant capacity, and levels of malondialdehyde, SOD, Catalase and GPX. All rats were euthanized, testes were dissected out and spermatozoa were collected from the epididymis for analysis. Results: Sperm numbers, percentages of sperm viability and motility, and total serum testosterone increased in ginger and cinnamon and combined ginger and cinnamon treated diabetic rats compared with control groups. Serum testosterone, LH and FSH were higher compared to control group and also serum anti-oxidants (TAC, SOD, GPX and catalase) all were increased at the end of treatment. Combined ginger and cinnamon showed more intense increase in all parameters compare to ginger and cinnamon alone. Most of the results were significant (P<0.05). Conclusion:We concluded that combined ginger and cinnamon have significant beneficial effects on the sperm viability, motility, and serum total testosterone, LH,FSH and serum anti-oxidants' level and could be effective for maintaining healthy sperm parameters and male reproductive function in diabetics.

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Effects of Glucose Load and Nateglinide Intervention on Endothelial Function and Oxidative Stress

Cited by 15 publications

References 27 publications

Acute Hyperglycemia Impairs Vascular Function in Healthy and Cardiometabolic Diseased Subjects

Acute Hyperglycemia Impairs Vascular Function in Healthy and Cardiometabolic Diseased Subjects

African star apple fruit pulp‐supplemented diet modulates fertility‐related biomolecules in the testis and epididymis of high‐fat diet/streptozotocin‐induced diabetic rats

The anti-oxidant effects of ginger and cinnamon on spermatogenesis dys-function of diabetes rats

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