Effects of glucocorticoids on the alkaline phosphomonoesterase isoforms

Abstract

Creation of a glucocorticoid depot in mice by daily subcutaneous injections of prednisolone in a dose of 30 mg/kg for a week or by a single injection of kenalog in a dose of 2 mg/kg modifies the activity of alkaline phosphomonoesterase differently in different organs. Polyacrylamide gel electrophoresis showed inhibition of the enzyme fiactions in some tissues and the appearance of additional isoforms in others.