Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus

Diz-Chaves, Yolanda; Herrera-Pérez, Salvador; González-Matías, Lucas C.; Mallo, Federico

doi:10.1016/bs.vh.2021.12.005

Cited by 8 publications

(22 citation statements)

References 112 publications

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“…GLP-1 is synthesized from the proglucagon gene after cell-specific post-translational processing by two members of the convertase subtilisin/kexin (PCSK) family ( Figure 1 ) [ 35 , 36 ]. The L-cells secrete GLP-1 at low basal levels in the fasting or interprandial state [ 37 ], and predominantly express the prohormone convertase 1 (PC1/3; Pcsk1).…”

Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

“…The L-cells secrete GLP-1 at low basal levels in the fasting or interprandial state [ 37 ], and predominantly express the prohormone convertase 1 (PC1/3; Pcsk1). In addition to GLP-1, proglucagon cleavage results in the liberation of glucagon-like peptide two (GLP-2), oxyntomodulin, glicentin and intervening peptide-2 (IP2) [ 36 , 38 ]. Pancreatic α-cells primarily express PC2 (Pcsk2), with low expression of PC1/3.…”

Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

“…Pancreatic α-cells primarily express PC2 (Pcsk2), with low expression of PC1/3. They produce glucagon, glicentin-related pancreatic polypeptide (GRPP), the significant proglucagon fragment (MPGF), and intervening peptide-1 (IP-1) [ 36 , 39 ]. In the intestine and to a lesser extent in the pancreatic α-cells, the processing of the proglucagon results in the formation of at least three GLP-1 peptides of 37, 31, and 30 residues [ 36 ].…”

Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

“…They produce glucagon, glicentin-related pancreatic polypeptide (GRPP), the significant proglucagon fragment (MPGF), and intervening peptide-1 (IP-1) [ 36 , 39 ]. In the intestine and to a lesser extent in the pancreatic α-cells, the processing of the proglucagon results in the formation of at least three GLP-1 peptides of 37, 31, and 30 residues [ 36 ]. The two N-terminally truncated products, a glycine extended peptide GLP-1(7–37) and GLP-1(7–36) amide, are recognized by the pancreatic receptor, and are the active species in vivo [ 40 ].…”

Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

“…The PPG cell bodies were also described in the adjacent medullary reticular formation in a population of glutamatergic olfactory bulb interneurons, the piriform cortex, and the lumbar-sacral spinal cord [ 44 , 45 , 46 , 47 , 48 , 49 ]. The NTS PPG neurons project to GLP-1 receptor (GLP-1R) expressing regions, with the hypothalamus being the primary target [ 36 ]. Other areas of the brainstem that control the autonomic function including the limbic forebrain regions [ 36 , 48 , 50 ], areas of the mesolimbic reward system related to control of feeding and motivation to feed [ 36 , 51 , 52 ], or structures implicated in the regulation of the stress response and the HPA axis, learning and memory [ 36 , 53 ], all receive neuronal projections from neurons of the NTS in rodents.…”

Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

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Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

Diz-Chaves

Mastoor

Spuch

et al. 2022

IJMS

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The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor signaling pathways. Several studies in vivo and in vitro using preclinical models of neurodegenerative diseases show that GLP-1R activation has anti-inflammatory properties. This review explores the molecular mechanistic action of GLP-1 RAS in relation to inflammation in the brain. These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response. These molecules emerge as a potential therapeutic tool in treating neurodegenerative diseases and neuroinflammatory pathologies.

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Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

Section: Glucagon-like Peptide 1 and The Glp-1 Receptor Agonistmentioning

confidence: 99%

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Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

Diz-Chaves

Mastoor

Spuch

et al. 2022

IJMS

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Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades

Mahmoud¹,

Mantawy²,

Wahdan³

et al. 2023

Biomedicine & Pharmacotherapy

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Memory improvement in senile rats after prebiotic and probiotic supplementation is not induced by GLP‐1

et al. 2022

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Introduction The mechanism underlying the memory improvement induced by prebiotic and probiotic supplementation remains unclear. Glucagon‐like peptide type 1 (GLP‐1) could play an important role since it is induced by prebiotics and enhances memory and learning. Aims We correlated the levels of GLP‐1 with spatial memory in senile animals to determine its role in memory improvement after prebiotic and probiotic supplementation. Methods Senile rats were randomly assigned to four groups: (1) water (control); (2) Enterococcus faecium (probiotic); (3) agave inulin (prebiotic); and (4) E. faecium + agave inulin (symbiotic). Each supplement was administered by an orogastric cannula for 5 weeks. In the fifth week, spatial memory was assessed using the Morris Water Maze test (MWM). We extracted the hippocampus, intestine, and serum. GLP‐1 levels were quantified by enzyme‐linked immunosorbent assay. Results A significant decrease in escape latency time in the MWM was observed in all groups treated with supplements. The symbiotic group achieved the highest reduction (15.13 s ± 6.40) (p < 0.01). We did not find a significant increase in GLP‐1 levels nor a direct correlation of its levels with spatial memory improvement (p > 0.05). Conclusion Prebiotic and probiotic supplementation improved spatial memory in senile animals. However, this beneficial effect did not correlate with GLP‐1 levels.

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Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus

Cited by 8 publications

References 112 publications

Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades

Memory improvement in senile rats after prebiotic and probiotic supplementation is not induced by GLP‐1

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