Effects of glucagon, Arg-vasopressin, and angiotensin II on rat hepatic zinc thionein levels

Helvig, Bethany S.; Brady, F.

doi:10.1016/0024-3205(84)90437-5

Cited by 11 publications

(1 citation statement)

References 19 publications

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“…33 In the mammalian liver, synthesis of T is rapidly induced by a variety of factors including zinc (to a lesser degree by copper, cadmium, iron, mercury, and others), hormones (corticosteroids, glucagon, catecholamines), cytokines (interleukin-1 [IL-1], IL-6, and interferon [IFN]), oxidants, nitric oxide (NO), and angiotensin II. 5,[35][36][37] Ursodiol has also been shown to increase levels of MT in hepatocytes. 38 MT has been considered an acute phase protein because it is highly inducible with tissue injury, sepsis, inflammation, and neoplastic disease.…”

Section: Zinc Transportersmentioning

confidence: 99%

The ubiquitous role of zinc in health and disease

Cummings

Kovacic

2009

J Vet Emergen Crit Care

109

114

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Historically, the role of zinc in health and disease has been studied through patients with toxicity or severe deficiency with obvious clinical signs. As the ubiquitous contribution of zinc to structure and function in biological systems was discovered, clinically significant but subtle deficiency states have been revealed. In human medicine, mild zinc deficiencies are currently thought to cause chronic metabolic derangement leading to or exacerbating immune deficiency, gastrointestinal problems, endocrine disorders, neurologic dysfunction, cancer, accelerated aging, degenerative disease, and more. Determining the causal relationships between mild zinc deficiency and concurrent disease is complicated by the lack of sensitive or specific tests for zinc deficiency. The prevalence of zinc deficiency and its contribution to disease in veterinary patients is not well known. Continued research is warranted to develop more sensitive and specific tests to assess zinc status, to determine which patients are at risk for deficiency, and to optimize supplementation in health and disease.

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