Effects of ginsenoside Rh2 on growth and migration of pancreatic cancer cells

Tang, Xiping; Tang, Guodu; Fang, Chunyun; Liang, Zhihai; Zhang, Luyi

doi:10.3748/wjg.v19.i10.1582

Cited by 75 publications

(63 citation statements)

References 29 publications

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“…30) GRh2 and GRg3 have been shown to have potent ability in inhibiting growth of different strains of tumor cells and to cause distinctive morphological changes. [31][32][33] It was reported that after 24 h of treatment with GRg3 (10 µM) and GRh2 (10 µM), hepatoma cells clearly exhibited condensed and fragmented nuclei, indicative of apoptotic cell death. 15) In this report, we observed that increasing concentration of 20(S)-GRh2 induced a marked increase in condensed apoptotic nuclei (Fig.…”

Section: Discussionmentioning

confidence: 99%

20(<i>S</i>)-Ginsenoside Rh2 Induces Apoptosis in Human Leukaemia Reh Cells through Mitochondrial Signaling Pathways

Xia

Wang

et al. 2014

Biological & Pharmaceutical Bulletin

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Section: Discussionmentioning

confidence: 99%

20(<i>S</i>)-Ginsenoside Rh2 Induces Apoptosis in Human Leukaemia Reh Cells through Mitochondrial Signaling Pathways

Xia

Wang

et al. 2014

Biological & Pharmaceutical Bulletin

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“…Previous studies reported that G-Rh2 could inhibit proliferation, invasion and metastasis of multiple human cancers. 24,25) Inducing apoptosis in cancer cells is an important mechanism of many anti-cancer agents in impairing malignant proliferation. It was believed that G-Rh2 is one of the multitarget anti-cancer drugs which could induce apoptosis of cancer cells by canonical signaling pathways, namely the death receptor-dependent and mitochondrial apoptosis pathways.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer Cells

Gao

Yan

Cai

2017

Biological & Pharmaceutical Bulletin

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Key words ginsenoside Rh2; lung cancer; apoptosis; reactive oxygen species; endoplasmic reticulum stress Followed by serial biological steps including hyperplasia, metaplasia, dysplasia and in situ carcinoma, similar to other cancers, lung cancer eventually develops its malignancy marked by strong proliferative capacity which is characterized by resistance to apoptosis. 1) Nowadays, lung cancer is still among the top common cancers worldwide. According to the records, lung cancer composes 12.7% of cancer and 18.2% of cancer related death.2) Though the multiple therapies including surgery, radiotherapy and chemotherapy are more and more widely applied to patients, the prognosis of lung cancer is still poor due to its malignant nature. Non-small cell lung cancer (NSCLC) takes approximately 85% of lung cancer cases with less than 20% 5-year survival rate.3) Seeking and identifying new drugs inducing apoptosis may provide us new insight into prevention and treatment of lung cancer.As one of the vital organelles in eukaryotic cells, endoplasmic reticulum (ER) is responsible for directing correct protein folding, calcium homeostasis and lipid metabolism. 4) However, under certain physiological and pathological conditions, the normal functions of ER were impaired by multiple extra-or intra-cellular stimuli, which is referred as ER stress.5) Reactive oxygen species (ROS) is considered as one of the stimuli inducing ER stress. This phenotype is called ROS-mediated ER stress. 6) Many anticancer agents such as chemotherapeutic drugs are believed to induce apoptosis by generating excessive intracellular ROS which is related with unfolded protein response (UPR) in ER to induce ER stress. 7) Numerous investigations supposed that ROS-mediated ER stress could further promote cell apoptosis by activating CCAAT/enhancer binding protein (C/EBP) homologous protein CHOP signaling pathway.8) As a pre-apoptotic factor, CHOP is suggested to activate caspase cascade by inducing cleavage of caspase-12 (rodents) 9) or caspase-4 (human). 10)In recent decades, natural products gradually become new alternatives besides regular therapies. With a long history in traditional medicine in East Asia, ginseng (Panax quinquefolius) is now a very popular herb as medicine or food supplement in the world. 11) Extracted from roots of ginseng, ginsenosides are the main effective components.12) It was suggested in the previous study that among the ginsenosides, ginsenoside Rh2 (G-Rh2, first isolated by Shizuo Odashima 13) ) exhibited various biological and pharmacological activities including anti-inflammation, anti-diabetes and anti-cancer. 14-17)A recent report supposed that G-Rh2 induced colorectal cancer cell apoptosis by inducing excessive intracellular ROS generation.18) Thus, ROS-mediated ER-stress induced apoptosis attracted our attention in investigating gensenoside Rh2's mechanism of anti-proliferation.In this present study, we showed G-Rh2 inhibited proliferation of lung cancer cells by inducing apoptosis. Furthermore, whether ROS-mediated ER-s...

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“…However, recent research has proved that these rare ginsenosides show relatively strong activities on anticancer. For example, ginsenosides Rh 2 can against human pancreatic, Colorectal, leukemia cancer cells Tang et al, 2013;Chung et al, 2013); ginsenosides Rg 3 can against human prostate, colon, breast, gastric cancer cells (Sun et al, 2010;Yuan et al, 2010;Chen et al, 2011;Kim et al, 2011;Pan et al, 2012); ginsenosides F 2 can against glioblastoma, breast cancer cells (Ji et al, 2012;Trang et al, 2012); ginsenosides compound K can against human lung adenocarcinoma, hepatoma, colorectal cancer cells Li et al, 2013) . Hence, these rare ginsenosides would develop into excellent anticancer drugs.…”

Section: Ginsenosidesmentioning

confidence: 99%

Biotransformation, a Promising Technology for Anti-cancer Drug Development

Gao

Zhang²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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With the high morbidity and mortality caused by cancer, finding new and more effective anti-cancer drugs is very urgent. In current research, biotransformation plays a vital role in the research and development of cancer drugs and has obtained some achievements. In this review, we have summarized four applications as follows: to exploit novel anti-cancer drugs, to improve existing anti-cancer drugs, to broaden limited anti-cancer drug resources and to investigate correlative mechanisms. Three different groups of important anti-cancer compounds were assessed to clarify the current practical applications of biotransformation in the development of anti-cancer drugs.

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Effects of ginsenoside Rh2 on growth and migration of pancreatic cancer cells

Abstract: Ginsenoside Rh2 inhibits proliferation, migration and invasion and induces apoptosis of the human pancreatic cancer cell line Bxpc-3.

Cited by 75 publications

References 29 publications

20(<i>S</i>)-Ginsenoside Rh2 Induces Apoptosis in Human Leukaemia Reh Cells through Mitochondrial Signaling Pathways

20(<i>S</i>)-Ginsenoside Rh2 Induces Apoptosis in Human Leukaemia Reh Cells through Mitochondrial Signaling Pathways

Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer Cells

Biotransformation, a Promising Technology for Anti-cancer Drug Development

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