Effects of ginsenoside Rb1 on the stress-induced changes of BDNF and HSP70 expression in rat hippocampus

Kim, Mia; Kim, Sung-Ok; Lee, Moonsung; Park, Yeri; Kim, Danhyo; Cho, Ki-Ho; Kim, Sun Yeou; Lee, Eunjoo H.

doi:10.1016/j.etap.2014.06.004

Cited by 18 publications

(9 citation statements)

References 28 publications

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“…Rb1 at 30 mg/kg normalized the percentage of time spent in the open arms in the elevated plus maze [ 104 ]. Rb1 (10 mg/kg), administered 30 min before acute immobilization stress, significantly inhibited the stress-mediated decline in BDNF mRNA level [ 108 ].…”

Section: Panax Ginseng Ca Meyermentioning

confidence: 99%

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

et al. 2017

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The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored. The present review considers the literature on the effects of botanicals on BDNF. Botanicals considered were Bacopa monnieri (L.) Pennell, Coffea arabica L., Crocus sativus L., Eleutherococcus senticosus Maxim., Camellia sinensis (L.) Kuntze (green tea), Ginkgo biloba L., Hypericum perforatum L., Olea europaea L. (olive oil), Panax ginseng C.A. Meyer, Rhodiola rosea L., Salvia miltiorrhiza Bunge, Vitis vinifera L., Withania somnifera (L.) Dunal, and Perilla frutescens (L.) Britton. The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well. The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects. Further clinical studies are mandatory to confirm botanicals as preventive agents or as useful adjuvant to the pharmacological treatment.

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Section: Panax Ginseng Ca Meyermentioning

confidence: 99%

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

et al. 2017

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“…Our recent work showed that Rb1 can ameliorate motor deficits in PD animal models through protecting DA neuron from glutamate transporter GLT-1 reduction-mediated glutamate excitotoxicity [35]. Previously, Rb1 was reported to regulate hippocampal neurogenesis, stress-induced brain-derived neurotrophic factor (BDNF) changes, and hippocampal synaptic density to improve spatial learning and memory [36–38]. Whether Rb1 can improve the cognitive impairment in PD remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway

Meng

Liu

et al. 2019

Aging

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Memory deficiency is a common non-motor symptom of Parkinson’s disease (PD), and conventionally, α-synuclein is considered to be an important biomarker for both motor and cognitive characteristics attributed to PD. However, the role of physiological α-synuclein in cognitive impairment remains undetermined. Ginsenoside Rb1 has been shown to protect dopaminergic neurons (DA) from death and inhibit α-synuclein fibrillation and toxicity in vitro . Our recent study also revealed that ginsenoside Rb1 ameliorates motor deficits and prevents DA neuron death via upregulating glutamate transporter GLT-1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. Whether Rb1 can improve memory deficiency and the underlying mechanism is still unknown. In this study, we found that Rb1 can prevent the spatial learning and memory deficits, increase long-term potentiation (LTP) and hippocampal glutamatergic transmission in the MPTP mouse model. The underlying neuroprotective mechanism of Rb1-improved synaptic plasticity involves Rb1 promoting hippocampal CA3 α-synuclein expression, restoring the glutamate in the CA3-schaffer collateral-CA1 pathway, and sequentially increasing postsynaptic density-95 (PSD-95) expression. Thus, we provide evidence that Rb1 modulates memory function, synaptic plasticity, and excitatory transmission via the trans-synaptic α-synuclein/PSD-95 pathway. Our findings suggest that Rb1 may serve as a functional drug in treating the memory deficiency in PD.

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“…(Araliaceae) and Panax quinquefolius L. (Araliaceae) regulate body temperature under both hypothermic and hyperthermic conditions, or high and low room temperature environments [ 11 ]. Additionally, ginsenoside Rb1 from ginseng was demonstrated to increase the expression of heat shock protein 70 in the rat hippocampus [ 12 ]. Moreover, in India, traditional healers of the Kancheepuram district commonly use a number of medicinal plants to treat fever, such as Wattakaka volubilis (L.f.) Stapf (Asclepiadaceae), Leucas aspera (Willd.)…”

Section: Introductionmentioning

confidence: 99%

Coptidis Rhizoma Prevents Heat Stress-Induced Brain Damage and Cognitive Impairment in Mice

et al. 2017

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Heat stress conditions lead to neuroinflammation, neuronal death, and memory loss in animals. Coptidis Rhizoma (CR) exhibits potent fever-reducing effects and has been used as an important traditional medicinal herb for treating fever. However, to date, the effects of antipyretic CR on heat-induced brain damages have not been investigated. In this study, CR significantly reduced the elevation of ear and rectal temperatures after exposure to heat in mice. Additionally, CR attenuated hyperthermia-induced stress responses, such as release of cortisol into the blood, and upregulation of heat shock protein and c-Fos in the hypothalamus and hippocampus of mice. The administration of CR inhibited gliosis and neuronal loss induced by thermal stress in the hippocampal CA3 region. Treatment with CR also reduced the heat stress-induced expression of nuclear factor kappa β, tumor necrosis factor-α, and interleukin-1β (IL-1β) in the hippocampus. Moreover, CR significantly decreased proinflammatory mediators such as IL-9 and IL-13 in the heat-stressed hypothalamus. Furthermore, CR attenuated cognitive dysfunction triggered by thermal stress. These results indicate that CR protects the brain against heat stress-mediated brain damage via amelioration of hyperthermia and neuroinflammation in mice, suggesting that fever-reducing CR can attenuate thermal stress-induced neuropathology.

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Effects of ginsenoside Rb1 on the stress-induced changes of BDNF and HSP70 expression in rat hippocampus

Cited by 18 publications

References 28 publications

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway

Coptidis Rhizoma Prevents Heat Stress-Induced Brain Damage and Cognitive Impairment in Mice

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