Effects of Ginkgo biloba extract on cytokines in rats with TNBS-induced ulcerative colitis

Zhou, Yanhong; Yu, Jie-Ping; He, Xiaofei; Yu, Xiqiu

doi:10.11569/wcjd.v12.i2.371

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…17) MPO activity was determined in colon homogenate spectrophotometrically according to the method of Krawisz et al 18) Determination of Colon NOx Production Colon NOx production, considered as an end product of NO metabolism, can be estimated in UC as an indication to enhanced inducible nitric oxide synthase (iNOS) activity. 19,20) NOx production in the colon was measured spectrophotometrically at 540 nm as previously described. 21) Determination of Colon MDA Production Lipid peroxidation, estimated by the determination of the level of thiobarbituric acid reactive species (TBARS), was measured as MDA in the colon homogenates spectrophotometrically at 520-535 nm as previously described.…”

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confidence: 99%

Is Coenzyme Q<sub>10</sub> Effective in Protection against Ulcerative Colitis? An Experimental Study in Rats

Ewees

Messiha

Abo-Saif

et al. 2016

Biological & Pharmaceutical Bulletin

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Coenzyme Q 10 (Co-Q 10 ) is a vitamin-like supplement which appears to be safe, with minimal side effects and low drug interaction potential. Co-Q 10 is used in the treatment of a variety of disorders related primarily to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of Co-Q 10 appear most promising for a variety of diseases, including ulcerative colitis (UC). The present investigation aims to elucidate the possible protective effects of Co-Q 10 against UC, as induced by the administration of iodoacetamide to adult male albino rats. In our study, Co-Q 10 showed potent anti-oxidant and anti-inflammatory activities through a significant increase in catalase activity and glutathione content. In addition, it significantly decreased myeloperoxidase activity, malondialdehyde content and nitrate/nitrite production. These results suggest that Co-Q 10 protects against UC in rats via anti-oxidant and anti-inflammatory potentials, and therefore seems promising for use in further clinical trials.

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