Effects of Ginkgo biloba extract on brain oxidative condition after cisplatin exposure

Aydın, Duygu; Peker, Emine Gülçeri Güleç; Karakurt, Meryem D; Gurel, Ayse; Ayyıldız, Mustafa; Cevher, Şule Çoşkun; Ağar, Erbil; Dane, Şenol

doi:10.25011/cim.v39i6.27511

Cited by 18 publications

(10 citation statements)

References 37 publications

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“…This hypothesis was further confirmed in the present study by the enhanced level of MDA (the end product of LPO) and PC (a reliable indicator for protein oxidation) in the brain. These results are in agreement with earlier reports 20,39. NO is a strong damaging free radical when produced in excess.…”

Section: Discussionsupporting

confidence: 94%

“…The involvement of NO in the toxicity of CDDP has been reported and was attributed to the enhancement of inducible NO syn-thase 40. Results from our study showed a marked increase in NO level in the brain of CDDP-administered rats which agrees with Aydin et al20 CDDP-induced changes in MDA, PC, and NO levels were significantly alleviated with NAC treatment. The ameliorative effect of NAC may be largely attributed to its ability to eradicate free radicals.…”

Section: Discussionsupporting

confidence: 91%

“…Group 5 (CDDP-NAC 100 ) was administered with 100 mg/kg of NAC and 8 mg/kg of CDDP. The doses of NAC and CDDP were selected based on the literature 18,20. Both CDDP and NAC were injected intraperitoneally in 0.9% saline.…”

Section: Methodsmentioning

confidence: 99%

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Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation

Abdel-Wahab¹,

Moussa²

2019

DDDT

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Background Neurotoxicity is a major obstacle to the effectiveness of cisplatin (CDDP) in cancer chemotherapy. Oxidative stress and inflammation are considered to be the major mechanisms involved in CDDP-induced neurotoxicity. The rationale of our study was to investigate the efficacy of N -acetylcysteine (NAC) at two different doses in the management of CDDP-induced toxicity in rat brain by monitoring its antioxidant and anti-inflammatory effects. Methods Thirty-five male rats were divided into five groups (n=7) as follows: control group (0.5 mL saline), NAC 100 group (100 mg/kg), CDDP group (8 mg/kg), NAC 50 -CDDP group (50 mg/kg NAC and 8 mg/kg CDDP), and NAC 100 -CDDP group (100 mg/kg NAC and 8 mg/kg CDDP). NAC was administered for 20 consecutive days, while CDDP was injected once on day 15 of the treatment protocol. Results The neurotoxicity of CDDP was evidenced by a marked increase in acetylcholinesterase and monoamine oxidase activities. It also induced oxidative stress as indicated by increased levels of lipid peroxidation, nitric oxide, and protein carbonyl with a concomitant decline in reduced glutathione, glutathione peroxidase, glutathione S-transferase, superoxide dismutase, and catalase in the brain. Moreover, CDDP enhanced the synthesis of pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6. Treatment with NAC at the two selected doses significantly attenuated CDDP-induced changes in the brain cholinergic function, improved the brain oxidant/antioxidant status, and also reversed the overproduction of pro-inflammatory cytokines in brain and serum. Conclusion NAC could serve as an appropriate and safe complementary therapeutic agent to attenuate the toxicity of CDDP in the brain and therefore improve its outcomes in chemotherapy.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 91%

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Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation

Abdel-Wahab¹,

Moussa²

2019

DDDT

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“…The primary evidence of neurotoxicity of cisplatin is decreased activity of antioxidant enzymes with concomitant depletion in the glutathione level, elevated lipid membrane peroxidation, and mitochondrial dysfunction. This indicates that cisplatin causes overproduction of ROS and imbalance between oxidant-antioxidant levels, consequently leading to the insufficient level of antioxidants to counteract the raised ROS in tissue [3]. Besides, cisplatin-induced neurotoxicity has been shown to result in numerous clinical forms.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effects ofSatureja hortensisL. Attenuate the Anxiogenic Effect of Cisplatin in Rats

Kumburović

Selaković

Jurić

et al. 2019

Oxidative Medicine and Cellular Longevity

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Numerous adverse effects of cisplatin-based therapy are usually accompanied by enhanced oxidative damage and cell apoptosis in various tissues. Even neurotoxic manifestations of cisplatin administration, such as the anxiogenic effect, appear along with the increased oxidative stress and apoptotic indicators in certain brain regions. Thirty-five Wistar albino male rats were divided into seven groups: control, cisplatin (received a single dose of cisplatin: 7.5 mg/kg), three groups with oral administration ofSatureja hortensisL. methanolic extract (SH) (low: 50 mg/kg, middle: 100 mg/kg, and high dose: 200 mg/kg) along with cisplatin application, a group with the extract in high dose alone, and a silymarin group (cisplatin and silymarin: 100 mg/kg), in order to evaluate the antioxidant effects of SH on cisplatin-induced increase in the anxiety level. After completing 10-day pretreatments, behavioral testing was performed in the open field and the elevated plus maze, followed by an investigation of oxidative stress and apoptosis parameters in hippocampal tissue samples. Cisplatin administration resulted in anxiogenic-like behavior, increased lipid peroxidation, and proapoptotic markers accompanied by the decline in antioxidant and antiapoptotic defense. The administration of extract alone did not significantly alter any of the estimated parameters. When applied along with cisplatin, SH in a dose of 100 mg/kg induced the significant anxiolytic effect with concomitant recovery of antioxidant and antiapoptotic activity indicators, while both lower and higher doses of the extract failed to improve the adverse effects of cisplatin administration. The beneficial effects of the middle dose of SH were equivalent to the same dose of silymarin, as a “golden standard.” Our results indicate that the antioxidant supplementation with SH in an optimal dose significantly improved the oxidative status and it had antiapoptotic effect in the rat hippocampus disturbed by cisplatin administration, which was accompanied with attenuation of cisplatin-induced anxiogenic effect.

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“…EGb 761 could be protective against ischemic injury by regulating oxidative stress. Aydin D induced oxidation in rat brains by administering cisplatin and found that EGb 761 could decrease the level of NO and GSH in brain tissue, thereby reducing oxidative stress[ 17 ]. Similarly, EGb 761 possessed the ability to reverse the decrease in GSH and GSH-peroxidase levels induced by intermittent hypoxia in rats [ 18 ].…”

Section: Pharmacological Actions Of Egbmentioning

confidence: 99%

Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases

Zuo¹,

Yan²,

Zhang³

et al. 2017

Aging and disease

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The prevalence of degenerative disorders in public health has promoted in-depth investigations of the underlying pathogenesis and the development of new treatment drugs. Ginkgo biloba leaves extract (EGb) is obtained from Ginkgo biloba leaves and has been used for thousands of years. In recent decades, both basic and clinical studies have established the effects of EGb. It is widely used in various degenerative diseases such as cerebrovascular disease, Alzheimer’s disease, macroangiopathy and more. Here, we reviewed several pharmacological mechanisms of EGb, including its antioxidant properties, prevention of mitochondrial dysfunctions, and effect on apoptosis. We also described some clinical applications of EGb, such as its effect on neuro and cardiovascular protection, and anticancer properties. The above biological functions of EGb are mainly focused on aging-related disorders, but its effect on other diseases remains unclear. Thus, through this review, we aim to encourage further studies on EGb and discover more potential applications

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Effects of Ginkgo biloba extract on brain oxidative condition after cisplatin exposure

Cited by 18 publications

References 37 publications

<p>Neuroprotective effect of <em>N</em>-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation</p>

<p>Neuroprotective effect of <em>N</em>-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation</p>

Antioxidant Effects ofSatureja hortensisL. Attenuate the Anxiogenic Effect of Cisplatin in Rats

Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases

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