Effects of Gentianine on the Production of Pro-inflammatory Cytokines in Male Sprague-Dawley Rats Treated with Lipopolysaccharide (LPS)

Successful treatment of spondylolisthesis with medicinal herbs

“…Oleanolic acid glycosides from Achyranthes bidentata inhibit osteoclast formation 20 . Gentianine, a constituent of Gentiana macrophylla suppressed the increase in tumor necrosis factor‐α and interleukin‐6 in the sera of rats challenged with bacterial lipopolysaccharide 21 . A new triterpene derivative isolated from Poria cocos , 3‐β‐p‐hydroxybenzoyldehydrotumulosic acid showed marked inhibitory activity against 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) and arachidonic acid (AA)‐induced ear inflammation in mice 22 .…”

“…20 Gentianine, a constituent of Gentiana macrophylla suppressed the increase in tumor necrosis factor-a and interleukin-6 in the sera of rats challenged with bacterial lipopolysaccharide. 21 A new triterpene derivative isolated from Poria cocos, 3-b-phydroxybenzoyldehydrotumulosic acid showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA) and arachidonic acid (AA)-induced ear inflammation in mice. 22 Ligustrazine, ligustilide and ferulic acid Ligusticum, effective components of Ligusticum chuanxiong, improved microcirculation through inhibiting thrombus formation and platelet aggregation as well as blood viscosity.…”

Determination of the metabolic profile of gentianine after oral administration to rats by high performance liquid chromatography/electrospray ionization-trap mass spectrometry

“…A mixture of G0 (618 mg, 3.51 mmol), [5,10,15,20-tetrakis(4-methoxyphenyl)-21H,23H-porphinato]cobalt(II) (500 mg, 0.63 mmol), and triethylsilane (418 mg, 3.60 mmol) in 200 mL of 2-propanol-dichloromethane (1:1) was stirred at 28 • C under oxygen at atmospheric pressure for 24 h. The solvent was removed under reduced pressure, and then the crude product was subjected to a silica gel column with CHCl 3 -acetone (20:1) to yield gentianone (IS, 606 mg, 3.17 mmol, 90% yield). IS: Colorless needles.…”

“…1) is the major alkaloid of Gentiana macrophylla Radix which has been used for the treatment of inflammatory diseases such as osteoarthritis and rheumatoid arthritis in oriental medicine [1][2][3][4]. Up to now, pharmacological studies of G0 have revealed various biological activities including anti-ulcerogenic activity, anti-inflammatory activity and anti-analgesic activity [5][6][7].…”

Anti-inflammatory activity ofGentiana striataMaxim.

“…Plants belonging to Gentiana are widely used in traditional medicines in many countries. Among them, Gentiana Macrophylla Radix., has been used for the treatment of inflammatory diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA) in oriental medicine (Kwak et al, 2005). Gentiana striata Maxim.…”