Effects of genistein on insulin pathway-related genes in mouse differentiated myoblast C2C12 cell line: evidence for two independent modes of action

Lewicki, Sławomir; Lewicka, Aneta; Kalicki, Bolesław; Sobolewska-Ruta, Agnieszka; Debski, Bogdan; Zdanowski, Robert; Syryło, Tomasz; Kloc, Małgorzata; Kubiak, Jacek Z.

doi:10.5603/fhc.a2018.0014

Cited by 11 publications

(3 citation statements)

References 35 publications

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“…Glucose-related pathways, such as tyrosine phosphorylation, changes in insulinreceptor counts, disrupted glucose transportation, and intracellular phosphorylation [28]. Besides, the alphaglucosidase enzyme can be inhibited by the genistein [29]. Hyperglycemia can decrease by inhibiting the alpha-glucosidase enzyme's effect when the amount of monosaccharides that can be consumed by the gut is reduced [30].…”

Section: Genistein As Antioxidantmentioning

confidence: 99%

Antioxidant Activities of Genistein: A Review

Burhan¹,

Oktavia²,

Fauziah³

2020

IJPSM

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Section: Genistein As Antioxidantmentioning

confidence: 99%

Antioxidant Activities of Genistein: A Review

Burhan¹,

Oktavia²,

Fauziah³

2020

IJPSM

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“…Using a mouse culture model C 2 C1 2 myogenic cell line [227], glucose transport and oxidation of fatty acids by measuring the radioactivity of 2-deoxy-D-[1,2-3 H]-glucose and [9,10-3 H]palmitic acid, respectively, were investigated. The dose of genistein was 0.1, 1, and 50 μM.…”

Section: Antidiabetes and Effects On Lipidmentioning

confidence: 99%

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

Sharifi‐Rad

Quispe

Imran

et al. 2021

Oxidative Medicine and Cellular Longevity

175

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Genistein is an isoflavone first isolated from the brooming plant Dyer’s Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of genistein have been reported in preclinical studies, such as the antioxidant, anti-inflammatory, antibacterial, and antiviral activities, the effects of angiogenesis and estrogen, and the pharmacological activities on diabetes and lipid metabolism. The purpose of this review is to provide up-to-date evidence of preclinical pharmacological activities with mechanisms of action, bioavailability, and clinical evidence of genistein. The literature was researched using the most important keyword “genistein” from the PubMed, Science, and Google Scholar databases, and the taxonomy was validated using The Plant List. Data were also collected from specialized books and other online resources. The main positive effects of genistein refer to the protection against cardiovascular diseases and to the decrease of the incidence of some types of cancer, especially breast cancer. Although the mechanism of protection against cancer involves several aspects of genistein metabolism, the researchers attribute this effect to the similarity between the structure of soy genistein and that of estrogen. This structural similarity allows genistein to displace estrogen from cellular receptors, thus blocking their hormonal activity. The pharmacological activities resulting from the experimental studies of this review support the traditional uses of genistein, but in the future, further investigations are needed on the efficacy, safety, and use of nanotechnologies to increase bioavailability and therapeutic efficacy.

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“…In this regard, it has been hypothesized that activation of the PI3K/AKT signaling pathway by SARS‐CoV‐2 contributes to inducing glucose uptake through GLUT‐4 leading to increase glycolysis and viral replication in host cells (Malgotra & Sharma, 2021 ). Since it has been reported that genistein is a potent and direct inhibitor of GLUT‐4 (Lewicki et al, 2018 ), the direct inhibition of GLUT‐4 by genistein from one side and inhibition of the PI3K/AKT pathway from another side could disrupt the viral replication (Figure 2 ). Furthermore, due to the involvement of the PI3K/AKT pathway in clot formation, targeting this pathway by genistein could prevent thrombosis in COVID‐19 patients.…”

Section: Pharmacological Effects Of Genistein As a Probable Beneficia...mentioning

confidence: 99%

An overview of possible pivotal mechanisms of Genistein as a potential phytochemical against SARS‐CoV‐2 infection: A hypothesis

Jafari

Esmaeilzadeh

Khezri

et al. 2022

Journal of Food Biochemistry

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The Coronavirus Disease 2019 (COVID‐19) pandemic has been caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It is a global problem that humanity has not yet found a definitive solution for it. In this regard, a global effort has been done to find effective or potential adjuvant therapies in order to fight this infection. Genistein is a small, biologically active phytoestrogen flavonoid that is found in high amounts in soy and plants of the Fabaceae family. This important compound is known due to its anti‐cancer, anti‐inflammatory, and antioxidant effects. Additionally, protective effects of genistein have been reported in different pathological conditions through modulating intracellular pathways such as PI3K, Akt, mTOR, NF‐κB, PPARγ, AMPK, and Nrf2. Scientific evidence suggests that genistein could have a potential role to treat COVID‐19 through its anti‐inflammatory and anti‐oxidant effects. Furthermore, it appears to interfere with intracellular pathways involved in viral entry into the cell. This review provides a basis for further research and development of clinical applications of genistein as a potential alternative therapy to decrease inflammation and oxidative stress in COVID‐19 patients. Practical applications The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the etiological agent for the Coronavirus Disease 2019 (COVID‐19), has brought unprecedented untold hardship to both developing and developed countries. The inflammation, cytokine storm, and oxidative stress have an important role in the pathogenesis of this infection. In this regard, finding plant‐derived compounds with anti‐inflammatory and anti‐oxidative effects would be very beneficial in reducing the mortality induced by this infection. Genistein an isoflavone derived from soy‐rich products possesses versatile biological activities. It has potent anti‐inflammatory and anti‐oxidative and immunomodulatory effects. Furthermore, this compound may prevent viral entry to host cells and reduce SARS‐CoV2‐induced lung injury. Therefore, we suggest further studies on the effects of genistein on SARS‐Cov‐2 infection.

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Effects of genistein on insulin pathway-related genes in mouse differentiated myoblast C2C12 cell line: evidence for two independent modes of action

Abstract: The results of this study showed that depending on the concentration and time of incubation genistein significantly affects glucose and lipid metabolism and at low concentration modifies expression pattern of a few genes in C2C12 cells.

Cited by 11 publications

References 35 publications

Antioxidant Activities of Genistein: A Review

Antioxidant Activities of Genistein: A Review

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

An overview of possible pivotal mechanisms of Genistein as a potential phytochemical against SARS‐CoV‐2 infection: A hypothesis

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