Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance
Xuanyu Lyu,
S. Mason Garrison
Abstract:The current study explored the impact of genetic relatedness differences (ΔH) and sample size on the performance of non-classical ACE models, with a focus on same-sex and opposite-sex twin groups. By extending Visscher (2004)’s least squares paradigm and conducting simulations, we illustrated how genetic relatedness of same-sex twins (HSS) influences the statistical power of additive genetic estimates (A), AIC-based model performance and the frequency of negative estimates. We found that larger HSS and increas… Show more
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