Effects of Genetic Polymorphisms of Cyp2c9/19 and Metabolic Inhibition by Coadministered Drugs on the Inter- And Intra- Individual Variations in the Warfarin-Induced Anticoagulation

Takahashi, Harumi; Nomizo, Yuko; Muramoto, Nagisa; Echizen, Hirotoshi; Kashima, Toshitaka; Kimura, Sosuke; Yasumori, Toshio; Nasu, Kayoko; Kubota, Takeshi; Tainaka, Hitoshi

doi:10.2133/dmpk.12.supplement_128

Cited by 1 publication

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“…Lower aspirin doses might be necessary for individuals with reduced CYP2C9 enzyme activity. By aligning the dosage with an individual's genetic makeup, healthcare providers can balance the antiplatelet effects of aspirin with the potential bleeding risk, offering a safer and more effective treatment approach [174,175].…”

Section: Cyp2c9 Gene Variations As a Key Factor In Aspirin Response A...mentioning

confidence: 99%

Pharmacogenetics and Pharmacogenomics Impact on Aspirin Response

Aftab Siddiqui,

Jain,

Usmani

et al. 2024

Pharmacogenomics and Pharmacogenetics in Drug Therapy

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Aspirin, or Acetylsalicylic acid (ASA), is renowned for its pain-relieving and anti-inflammatory properties. Recent insights have illuminated its mechanisms and potential applications. Notably, low-dose aspirin reduces heart attack and stroke risks, particularly in high-risk individuals, yet optimal dosing remains under investigation. Another area explores aspirin’s potential in cancer prevention, especially for colon and gastrointestinal cancers, along with emerging roles against conditions like Alzheimer’s, diabetes, and pre-eclampsia. Aspirin’s benefits extend to kidney disease and COVID-19 research due to its anti-inflammatory actions. Stem cell effects are diverse; while enhancing hematopoietic stem cells aids bone marrow transplants, it may inhibit embryonic stem cells in specific contexts. However, challenges encompass resistance, allergies, gastrointestinal effects, and pediatric Reye’s syndrome. Pharmacogenetic studies illuminate how genetic variations impact aspirin metabolism, with enzymes like CYP2C9 and CYP2C19 affecting clearance rates, and markers such as P2RY12 and COX-1 influencing antiplatelet responses. Customized aspirin therapy, guided by genetic profiles, optimizes benefits and minimizes risks. This research underpins personalized medicine, empowering clinicians to enhance treatment precision, efficacy, and safety. As aspirin’s complex advantages and challenges continue to unfold, refined therapeutic strategies will emerge.

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Section: Cyp2c9 Gene Variations As a Key Factor In Aspirin Response A...mentioning

confidence: 99%