Effects of genetic and nutritional factors on bone mineral density in young adults.

Otsuki, Takemi; Sakaguchi, Haruko; Hatta, Emiko; Hatayama, Tamayo; Hatada, Satomi; Miura, Yoshie; Takata-Tomokuni, Akiko; Hyodoh, Fuminori; Tomomitsu, Tatsushi; Fukunaga, Masao; Katsuyama, Hironobu

doi:10.3892/ijmm.14.4.669

Cited by 3 publications

(10 citation statements)

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“…It is assumed that the relationship measured by QUS, that is considered be better accepted for routine health check-ups, indicates the importance of underling food intake in health education to prevent osteoporosis. Several studies have reported on bone mass level and food intake among young women (Sawa et al 2001;Tomita et al 2004;Otsuki et al 2004;Ueno et al 2005;Prynne et al 2006), but the report of a positive relationship between bone mass level and the intake of green and yellow vegetables has been limited. Our result is in line with Otsuki's report demonstrating that intake of green and yellow vegetables showed a correlation with bone mineral density that was measured by DXA at the lumbar spine in young adults (Otsuki et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies in young Japanese women have reported a positive relationship between BMI and bone indices (Sawa et al 2001;Otsuki et al 2004;Ibuka et al 2004;Yokouchi et al 2006). We think that the reason may have been the method of measurement; height and weight for calculating BMI was examined by a selfreported questionnaire.…”

Section: Discussionmentioning

confidence: 99%

“…In previous reports (Sakamoto and Miyoshi 2000;Sawa et al 2001;Tomita et al 2004;Ibuka et al 2004;Otsuki et al 2004;Yokouchi et al 2006), the bone mass level has been shown to be related to various lifestyle factors in young adults. A correlation between intake of green and yellow vegetables and bone mineral density measured by dual X-ray absorptiometry (DXA) has been reported in young adults (Otsuki et al 2004).…”

mentioning

confidence: 99%

“…A correlation between intake of green and yellow vegetables and bone mineral density measured by dual X-ray absorptiometry (DXA) has been reported in young adults (Otsuki et al 2004). It is important to show the relationship between the bone mass level and dietary pattern on a personal basis as one of the health education methods for maintaining bone mass at a normal level.…”

mentioning

confidence: 99%

“…In young women, being underweight is considered one of the determinants of low bone mass (Sawa et al 2001;Otsuki et al 2004;Ibuka et al 2004;Ho and Kung 2005;Yokouchi et al 2006;Arimatsu et al 2009). The proportion of young Japanese women, especially those in their 20s, who are underweight, has increased, from 18.6% in 1987 to 25.2% in 2007 (Ministry of Health, Labour and Welfare of Japan 2009).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Daily Intake of Green and Yellow Vegetables Is Effective for Maintaining Bone Mass in Young Women

Fujii

Noda

Sairenchi

et al. 2009

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Daily Intake of Green and Yellow Vegetables Is Effective for Maintaining Bone Mass in Young Women

Fujii

Noda

Sairenchi

et al. 2009

Tohoku J. Exp. Med.

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Association between an <i>Alu</i>I Polymorphism in the Calcitonin Receptor Gene and Quantitative Ultrasound Parameters in Korean Men

Kang

Kim²,

Lee³

2007

Med Princ Pract

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Objective: The purpose of this study was to investigate the association between an AluI RFLP of the calcitonin receptor (CTR) gene and quantitative ultrasound (QUS) parameters in Korean men, and the interaction with nutrition as a lifestyle factor. Materials and Methods: Broadband ultrasound attenuation, speed of sound and stiffness index of the calcaneus were measured using an ultrasound bone densitometer in 201 Korean men (mean age ± SD: 51.6 ± 11.7 years). The PCR-RFLP method was used to analyze an AluI polymorphism in the CTR gene. Results: In all subjects, the distribution of CC, CT and TT genotypes occurred with frequencies of 87.1, 12.4 and 0.5%, respectively. When stratified by omnivore and vegetarian groups, there was a significant association between an AluI polymorphism in the CTR gene and QUS parameters such as speed of sound and stiffness index in only vegetarian subjects. Conclusion: Our data suggest that the AluI polymorphism of the CTR gene can be useful as a genetic marker in the interindividual susceptibility of QUS parameters by the interaction with nutritional status as a lifestyle factor.

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Vitamin K Supplementation Modulates Bone Metabolism and Ultra-Structure of Ovariectomized Mice

Rangel¹,

Siqueira²,

Soares³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Osteoporosis is a bone metabolic disease that affects mostly post-menopausal women. There has been shown that vitamin K (VK) supplementation during menopause may decrease bone loss as well as risk of bone breaking. Aiming to clarify the beneficial role of VK in bone metabolism during menopause, we investigated mineral metabolism and bone ultrastructure of ovariectomized (OVX) mice. Methods: To determine the effects chronic use of VK in bone structure and mineral metabolism in OVX mice, we used several methods, such as DXA, µCTScan, and SEM as well as biomolecular techniques, such as ELISA and qRT-PCR. In addition, complete analysis of serum hormonal and other molecules associated to bone and lipid metabolism were evaluated overview the effects of VK in menopause murine model. Results: VK treatment significantly affects Pi metabolism independently of OVX, changing Pi plasma, urinary output, balance, and Pi bone mass. Interestingly, VK also increased VLDL in mice independently of castration. In addition, VK increased compact bone mass in OVX mice when we evaluated it by DXA, histomorphometry, µCTScanning. VK increased bone formation markers, osteocalcin, HYP- osteocalcin, and AP whereas it decreased bone resorption markers, such as urinary DPD/creatinine ratio and plasmatic TRAP. Surprisingly, SEM images revealed that VK treatment led to amelioration of microfractures observed in OVX untreated controls. In addition, SHAM operated VK treated mice exhibited higher number of migrating osteoblasts and in situ secretion of AP. OVX led to decreased to in situ secretion of AP that was restored by VK treatment. Moreover, VK treatment increased mRNA expression of bone Calbindin 28KDa independently of OVX. Conclusion: VK treatment in OVX mice exhibited beneficial effects on bone ultrastructure, mostly by altering osteoblastic function and secretion of organic bone matrix. Therefore, VK could be useful to treat osteopenic/osteoporotic patients.

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Effects of genetic and nutritional factors on bone mineral density in young adults.

Cited by 3 publications

References 0 publications

Daily Intake of Green and Yellow Vegetables Is Effective for Maintaining Bone Mass in Young Women

Daily Intake of Green and Yellow Vegetables Is Effective for Maintaining Bone Mass in Young Women

Association between an <i>Alu</i>I Polymorphism in the Calcitonin Receptor Gene and Quantitative Ultrasound Parameters in Korean Men

Vitamin K Supplementation Modulates Bone Metabolism and Ultra-Structure of Ovariectomized Mice

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