Effects of general anaesthetics on neuronal sodium and potassium channels

Elliott, James R.; Elliott, A. A.; Harper, Alexander A.; Winpenny, John P.

doi:10.1016/0306-3623(92)90278-r

Cited by 19 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although effective in blocking gap junctional transmission of electrical signals or dyes, common uncoupling agents have been reported to cause many other effects (Bennett et al 1991). For example, they often suppress membrane Na+ currents, including INap, in the same concentration range as is needed to uncouple cells (Elliott et al 1992). This is consistent with the present results showing that heptanol abolished Nae-dependent fast spikes.…”

Section: Roles Of Gap Junctionssupporting

confidence: 91%

Oscillatory bursting of phasically firing rat supraoptic neurones in low‐Ca2+ medium: Na+ influx, cytosolic Ca2+ and gap junctions.

Hatton

1996

The Journal of Physiology

View full text Add to dashboard Cite

1. Whole-cell patch recordings were obtained from supraoptic nucleus (SON) Magnocellular neurones in the hypothalamic supraoptic distinct firing patterns and membrane events. For example, nucleus (SON) are known to participate in regulation of when activated either physiologically or by depolarizing body fluid homeostasis, reproduction and autonomic current injection, vasopressinergic neurones in the rat functions through release of vasopressin and oxytocin from hypothalamus display phasic firing patterns and the posterior pituitary and fibre projections to the lateral depolarizing after-potentials (DAPs) following action hypothalamus (for review see Hatton, 1990). When potentials. In contrast, the vast majority (Armstrong, recorded in vivo or in vitro using conventional electro-Smith & Tian, 1994) of oxytocinergic neurones fire physiological methods, these cells are characterized by continuously and show no DAPs (Andrew & Dudek, 1983;

show abstract

Section: Roles Of Gap Junctionssupporting

confidence: 91%

Oscillatory bursting of phasically firing rat supraoptic neurones in low‐Ca2+ medium: Na+ influx, cytosolic Ca2+ and gap junctions.

Hatton

1996

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…The microdialysis studies employed halothane anesthesia, which reduces K + conductance (Elliott et al, 1992, Mathie, 2007), a parameter consistently altered by 5-HT 2C R activation (North and Uchimura, 1989, Stevens et al, 1992, Hu et al, 1998, Di Giovanni et al, 1999, Speake et al, 2004, Xiang et al, 2005, Weber et al, 2008), and a decreased K + conductance was likely involved in the current studies given the 5-HT 2C R-dependent increased input resistance. Alternatively, SB206 may be acting as an agonist in MSNs (and inverse agonist in dopamine neurons regulating dopamine release).…”

Section: Discussionmentioning

confidence: 99%

Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism

et al. 2015

View full text Add to dashboard Cite

Methamphetamine profoundly increases brain monoamines and is a widely abused psychostimulant. The effects of methamphetamine self-administration on neuron function are not known for the nucleus accumbens, a brain region involved in addictive behaviors, including drug-seeking. One therapeutic target showing preclinical promise at attenuating psychostimulant-seeking is 5-HT2C receptors; however, the effects of 5-HT2C receptor ligands on neuronal physiology are unclear. 5-HT2C receptor agonism decreases psychostimulant-mediated behaviors, and the putative 5-HT2C receptor inverse agonist, SB 206553, attenuates methamphetamine-seeking in rats. To ascertain the effects of methamphetamine, and 5-HT2C receptor inverse agonism and agonism, on neuronal function in the nucleus accumbens, we evaluated methamphetamine, SB 206553, and the 5-HT2C receptor agonist and Ro 60-0175, on neuronal excitability within the accumbens shell subregion using whole-cell current-clamp recordings in forebrain slices ex vivo. We reveal that methamphetamine self-administration decreased generation of evoked action potentials. In contrast, SB 206553 and Ro 60-0175 increased evoked spiking, effects that were prevented by the 5-HT2C receptor antagonist, SB 242084. We also assessed signaling mechanisms engaged by 5-HT2C receptors, and determined that accumbal 5-HT2C receptors stimulated Gq, but not Gi/o. These findings demonstrate that methamphetamine-induced decreases in excitability of neurons within the nucleus accumbens shell were abrogated by both 5-HT2C inverse agonism and agonism, and this effect likely involved activation of Gq–mediated signaling pathways.

show abstract

“…In contrast, the mice from the study were anesthetized with metofane and were, therefore, presumably less prone to sympathetic stimulation. In addition, metofane clearly affects some sodium and potassium currents (Elliott et al, 1992), further complicating interpretation of ECG data obtained in animals anesthetized with this compound. These complications are eliminated by the use of radiotelemetry.…”

Section: Discussionmentioning

confidence: 99%

Nicotine Induces a Long QT Phenotype in Kcnq1-Deficient Mouse Hearts

Tosaka

Casimiro²,

Qi³

et al. 2003

J Pharmacol Exp Ther

View full text Add to dashboard Cite

We have previously shown that targeted disruption of the mouse Kcnq1 gene produces a long QT phenotype in vivo that requires extracardiac factors for manifestation (Casimiro et al., 2001). In the present study, we explore the hypothesis that autonomic neuroeffector transmission represents the "extracardiac" stimulus that induces a long QT phenotype in mouse hearts lacking Kcnq1. Using the isolated perfused (Langendorff) mouse heart preparation, we challenged wild-type (Kcnq1 ϩ/ϩ ) and mutant (Kcnq1 Ϫ/Ϫ ) mouse hearts with nicotine, an autonomic stimulant. ECGs were recorded continuously, and QT intervals were compared at baseline and peak nicotineinduced heart rates. No significant differences in QT or any other ECG parameters were observed in Kcnq1 ϩ/ϩ versus Kcnq1 Ϫ/Ϫ hearts at baseline. In the presence of nicotine, however, the JT, QT, and rate-corrected QT (QTc) intervals were significantly prolonged in Kcnq1 Ϫ/Ϫ hearts relative to Kcnq1

show abstract

Effects of general anaesthetics on neuronal sodium and potassium channels

Cited by 19 publications

References 38 publications

Oscillatory bursting of phasically firing rat supraoptic neurones in low‐Ca2+ medium: Na+ influx, cytosolic Ca2+ and gap junctions.

Oscillatory bursting of phasically firing rat supraoptic neurones in low‐Ca2+ medium: Na+ influx, cytosolic Ca2+ and gap junctions.

Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism

Nicotine Induces a Long QT Phenotype in Kcnq1-Deficient Mouse Hearts

Contact Info

Product

Resources

About