Effects of General Anaesthesia on Portal Venous Pressure in the Rat

Belghiti, Jacques; Blanchet, L.; Lebrec, Didier

doi:10.1159/000128195

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…A recent study in rats anesthetized with ketamine+xylazine undergoing diverse surgical operations (median laparotomy, bile-duct ligation, or balloon dilatation of the carotid artery) suggested that hypoxia may be a contributing factor, as oxygen supplementation reduced the mortality [14]. Studies comparing the performance of different anesthetics in the setting of cirrhosis or portal hypertension, however, are scarce and limited to relatively old studies that do not include the newer anesthetic agents [13,[15][16][17][18][19] (see Table 1 for a summary).…”

Section: Introductionmentioning

confidence: 99%

Sevoflurane versus ketamine+diazepam anesthesia for assessing systemic and hepatic hemodynamics in rats with non-cirrhotic portal hypertension

et al. 2020

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The selection of the anesthetic regime is a crucial component in many experimental animal studies. In rodent models of liver disease, the combination of ketamine and diazepam (KD), generally by the intramuscular (i.m.) route, has traditionally been the anesthesia of choice for the evaluation of systemic and hepatic hemodynamics but it presents several problems. Here, we compared the performance of inhalational sevoflurane (Sevo) against the KD combination as the anesthesia used for hemodynamic studies involving the measurement of portal pressure in normal rats (Ctrl) and rats with non-cirrhotic portal hypertension induced by partial portal vein ligation (PPVL). Compared with Ctrl rats, rats with PPVL presented characteristic alterations that were not influenced by the anesthetic regime, which included liver atrophy, splenomegaly, increased plasma fibrinogen, decreased alkaline phosphatase and glycemia, and frequent ascites. The use of the KD combination presented several disadvantages compared with the inhalational anesthesia with sevoflurane, including considerable mortality, a higher need of dose adjustments to maintain an optimal depth of anesthesia, increases of heart rate, and alteration of blood biochemical parameters such as the concentration of aspartate aminotransferase, lactate, and lactic dehydrogenase. Rats anesthetized with sevoflurane, on the other hand, presented lower respiratory rates. Importantly, the anesthetic regime did not influence the measurement of portal pressure either in Ctrl or PPVL rats, with the increase of portal pressure being similar in Sevo-and KD-anesthetized groups of PPVL rats compared with their respective control groups. Overall, our results suggest that anesthesia with sevoflurane is preferable to the combination of KD for performing systemic and hepatic hemodynamic studies in rats with non-cirrhotic portal hypertension.

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Section: Introductionmentioning

confidence: 99%

Sevoflurane versus ketamine+diazepam anesthesia for assessing systemic and hepatic hemodynamics in rats with non-cirrhotic portal hypertension

et al. 2020

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“…Only one article describing two case reports of hepatic angiograms has been able to directly show this same effect of halothane in humans (20). The decrease in PVBF may be attributed to mesenteric vasoconstriction, as reported in the animal literature (21), although we did not measure portal venous pressure in this study. In a human study using the same methodology to assess mesenteric blood flow (supplying an esophageal ileocoloplasty), a smaller dose of halothane (0.8%) did not induce mesenteric vasoconstriction.…”

Section: Resultsmentioning

confidence: 59%

The Postoperative Effects of Halothane Versus Isoflurane on Hepatic Artery and Portal Vein Blood Flow in Humans

Gatecel

Losser

Payen

2003

Anesthesia & Analgesia

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“…However, in conscious, unrestrained animals, greater complexity in the hepatic circulation is emerging. Well-described, for example, is the marked decrease in portal pressure that occurs in animals under anesthesia [33][34][35][36][37]. It is also becoming apparent that postural changes have a profound influence on hepatosplanchnic hemodynamics [38][39][40], while marked changes in portal pressure brought on by glucagon infusion suggests a prandial link as well [33,41].…”

Section: Discussionmentioning

confidence: 99%