Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes

Liao, Chiung-Ho; Ho, Chi‐Tang; Lin, Jyh-Woei

doi:10.1016/j.bbrc.2005.02.110

Cited by 68 publications

(57 citation statements)

References 34 publications

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“…In fact, garcinol, a prenylated benzophenone structurally related with GA, presents potent free radical scavenging activity (47) and enhances neuronal survival in neuron-astrocyte co-cultures with lipopolysaccharide (LPS) treatment, reducing the expression of LPS-induced inflammatory mediators (48).…”

Section: Discussionmentioning

confidence: 99%

A Strong Protective Action of Guttiferone-A, a Naturally Occurring Prenylated Benzophenone, Against Iron-Induced Neuronal Cell Damage

et al. 2011

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Abstract. Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharmacological actions. We have assessed the protective action of GA on ironinduced neuronal cell damage by employing the PC12 cell line and primary culture of rat cortical neurons (PCRCN). A strong protection by GA, assessed by the 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carbox-anilide (XTT)

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Section: Discussionmentioning

confidence: 99%

A Strong Protective Action of Guttiferone-A, a Naturally Occurring Prenylated Benzophenone, Against Iron-Induced Neuronal Cell Damage

et al. 2011

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“…Dietary administration of carnosic acid reduces obesity in high-fat diettreated mice and decreases adipogenesis in obese ob/ob mice [193,194]. Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica fruit that has been reported to reduce NO accumulation in astrocytes and promote neuronal attachment and neurite extension in primary neuron that exert neuroprotective activity [195].…”

Section: Turmericmentioning

confidence: 99%

Molecular mechanisms for anti‐aging by natural dietary compounds

Pan

Lai

Tsai

et al. 2011

Molecular Nutrition Food Res

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Aging is defined as a normal decline in survival with advancing age; however, the recent researches have showed that physiological functions of the body change during the aging process. Majority of the changes are often subject to a higher risk of developing diseases, such as cardiovascular disease, type II diabetes, Alzheimer's disease, Parkinson's disease, as well as the dysregulated immune and inflammatory disorders. Aging process is controlled by a complicated and precise signaling network that involved in energy homeostasis, cellular metabolism and stress resistance. Over the past few decades, research in natural dietary compounds by various organism and animal models provides a new strategy for anti-aging. Natural dietary compounds act through a variety mechanisms to extend lifespan and prevent age-related diseases. This review summarizes the current understanding on signaling pathways of aging and knowledge and underlying mechanism of natural dietary compounds that provide potential application on anti-aging and improve heath in human.

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“…Moreover, its isolated constituents such as garcinol, hydroxycitric acid, and Cyanidin-3-glucoside, were also effective in neuroprotection (Antala et al 2012;Chen et al 2009;Liao et al 2005;Ohia et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway

2017

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Depression and anxiety are the most crippling neuropsychiatric disorders of this modern era. These mostly occur as anxiety followed by depression or in mixed state. Therefore, there is an urgent need of a safe and effective treatment, which proves its worth in this ailment. What else than a conventional food would be a better choice for a convenient therapy. Therefore, Garcinia indica, commonly known as Kokam, fruit rind has been used in the present study to investigate its antidepressant and anti-anxiety potential using forced swim test, tail suspension test, and reserpine-induced hypothermia; and elevated plus maze, hole-board test, and light dark model, respectively. Garcinia indica fruit rind given to mice with food for consecutive 14 days at 0.5, 1, and 2% w/w significantly (p \ 0.05) reduced despair behavior in forced swim test, immobility duration in tail suspension test, and also switched the hypothermia (reserpine induced) to normal temperature significantly (p \ 0.05). Garcinia indica significantly (p \ 0.05) raised the time elapsed and count of entries in open arms of elevated plus maze, enhanced incidence of head dipping in holes of hole board along with duration of expending time in lit compartment of light dark model, exhibiting its anti-anxiety effect. Garcinia indica significantly reduced monoamine oxidase and malondialdehyde levels providing support to neuroprotective potential of fruit rind. The mechanistic study showed the participation of G. indica at a 1 -adrenoceptor and D 2 -dopamine receptor, by attenuating prazosin and sulpirideinduced increase in immobility duration. Garcinia indica fruit rind showed a significant antidepressant and anxiolytic effect while no effect on locomotor activity, i.e., no psycho-stimulation.

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Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes

Cited by 68 publications

References 34 publications

A Strong Protective Action of Guttiferone-A, a Naturally Occurring Prenylated Benzophenone, Against Iron-Induced Neuronal Cell Damage

A Strong Protective Action of Guttiferone-A, a Naturally Occurring Prenylated Benzophenone, Against Iron-Induced Neuronal Cell Damage

Molecular mechanisms for anti‐aging by natural dietary compounds

Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway

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