“…These are summarised in Table 2 . Whilst a number of biological targets have proven promising in pre-clinical studies, translational success has often proven challenging [ 49 , 83 , 106 , 107 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 ]. Interventional studies continue to investigate novel targets and approaches but have thus far failed to prove efficacious in improving functional outcomes [ 16 , 69 , 178 , 179 ].…”