Effects of GandhPaalashi (Hedychium spicatum) on the expression of hepatic genes associated with biotransformation, antioxidant and immune systems in WLH cockerels fed indoxacarb

Choudhary, Govind Kumar; Singh, Satya Pal; Kumar, Amit

doi:10.56093/ijans.v88i7.81408

Cited by 2 publications

(2 citation statements)

References 11 publications

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Section: Methodsmentioning

confidence: 99%

“…The protective effect of Hedychium spicatum rhizome powder with concentrations of 4000 ppm and 2000 ppm was tested against 250 ppm IC 50 of Indoxacarb-induced toxicity on a group of cockerels. The ameliorative effect of Hedychium spicatum root powder and its ability to restore the gene activities and expression of antioxidant, biotransformation, and immune system genes were demonstrated in cockerels fed Indoxacarb [77,93,94]. The study concluded that 80% Aqueous acetone extract of Hedychium coronarium flower and other chemical constituents had a hepatoprotective effect, with a significant p < 0.01 value of percentage inhibition [25].…”

Section: Ameliorating Potentialmentioning

confidence: 95%

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A Comprehensive Review on Pharmacologically Active Phyto-Constituents from Hedychium species

et al. 2023

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In this review, we describe and discuss the phytoconstituents present in Hedychium species and emphasize their potential as drug candidates. Though they are widely validated in vitro and in vivo models, to date, no efforts have been made to compile in a single review all the pharmacologically active phytoconstituents from Hedychium species, and their pharmacological and toxicity profile. In this study, we present a reinvestigation of the chemical constituents present in Hedychium species obtained from the essential oil and solvent extraction of the flowers, leaves and rhizomes under consideration. Key databases such as PubMed, Science Direct, Scopus, and Google Scholar amongst others were probed for a systematic search using keywords to retrieve relevant publications on this plant. An exhaustive electronic survey of the related literature on Hedychium species resulted in around 200 articles. Articles published between the years 1975–2021 were included. The studies conducted on either crude extracts, solvent fractions or isolated pure compounds from Hedychium species reported with a varied range of biological effects such as anti-inflammatory, analgesic, antidiabetic, potentially anti-asthmatic, and cytotoxic, among other related activities of the chemical constituents present in its essential oil and solvent extract deployed in this review. Traditional and herbal medication around the world that uses different parts of Hedychium species were considered for anti-inflammatory, skincare, analgesic, anti-asthmatic, anti-diabetic, antidotal uses, among others. These uses support the idea that chemical constituents obtained from solvent extraction may also exert the same action individually or in a synergistic manner. The review concluded that there is scope for computation and biological study to find out possible new targets for strengthening the potency and selectivity of the relevant compounds, and to find a commercial method for extraction of active pharmaceutical ingredients.

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Section: Methodsmentioning

confidence: 99%

Section: Ameliorating Potentialmentioning

confidence: 95%

A Comprehensive Review on Pharmacologically Active Phyto-Constituents from Hedychium species

et al. 2023

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Uncharted Source of Medicinal Products: The Case of the Hedychium Genus

2020

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A current research topic of great interest is the study of the therapeutic properties of plants and of their bioactive secondary metabolites. Plants have been used to treat all types of health problems from allergies to cancer, in addition to their use in the perfumery industry and as food. Hedychium species are among those plants used in folk medicine in several countries and several works have been reported to verify if and how effectively these plants exert the effects reported in folk medicine, studying their essential oils, extracts and pure secondary metabolites. Hedychium coronarium and Hedychium spicatum are the most studied species. Interesting compounds have been identified like coronarin D, which possesses antibacterial, antifungal and antitumor activities, as well as isocoronarin D, linalool and villosin that exhibit better cytotoxicity towards tumor cell lines than the reference compounds used, with villosin not affecting the non-tumor cell line. Linalool and α-pinene are the most active compounds found in Hedychium essential oils, while β-pinene is identified as the most widespread compound, being reported in 12 different Hedychium species. Since only some Hedychium species have been investigated, this review hopes to shed some light on the uncharted territory that is the Hedychium genus.

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Effects of GandhPaalashi (Hedychium spicatum) on the expression of hepatic genes associated with biotransformation, antioxidant and immune systems in WLH cockerels fed indoxacarb

Cited by 2 publications

References 11 publications

A Comprehensive Review on Pharmacologically Active Phyto-Constituents from Hedychium species

A Comprehensive Review on Pharmacologically Active Phyto-Constituents from Hedychium species

Uncharted Source of Medicinal Products: The Case of the Hedychium Genus

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