Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway

Hosoyama, Yukiko; Domae, Eisuke; Goda, Seiji; Matsumoto, Naoyuki

doi:10.1016/j.odw.2016.10.007

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Accumulated evidence on the nutraceutical effects of NRCs and NRC-derived natural products on menopausal osteoporosis and obesity has been gathered by numerous studies. Gallotannin derivatives (e.g., galloyl glucosides, methyl gallate, ellagic acid, and epicatechin gallate) and flavonoids (e.g., catechin, kaempferol, quercetin, isoquercetin, and luteolin) have been shown to negatively regulate osteoclast differentiation and positively affect osteoblast differentiation in vitro, exerting protective effects on bone loss induced by estrogen deficiency or lipopolysaccharides in vivo [29][30][31][32][33]. Besides anti-osteoporotic activities, the phenolic fractions and gallotannins, including penta-O-galloyl-β-D-glucose from NRCs, have been shown to inhibit pancreatic lipase activity involved in fat absorption [11,34].…”

Section: Resultsmentioning

confidence: 99%

Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet

et al. 2019

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In traditional oriental medicine, nutgalls of Rhus chinensis have been used to treat various gastrointestinal and respiratory disorders. This study aimed to investigate the benefits of nutgalls of R. chinensis on bone loss and obesity in ovariectomized mice fed with a high-fat diet. Following surgical menopause induction, nutgalls of R. chinensis was orally administered for 4 weeks. Body weight gain and organ weights were measured. Histopathological examinations and UHPLC-MS/MS analysis were performed. Nutgalls of R. chinensis remarkably decreased obesity, gonadal fat, and bone loss in ovariectomized mice fed with a high-fat diet. Nutgalls of R. chinensis inhibited adipocyte differentiation of multipotent bone marrow stromal cells and reduced fat accumulation in gonadal fat, liver, and bone tissues. In UHPLC-MS/MS analysis, 27 phytochemicals containing gallotannin derivatives and flavonoids were identified by comparison with mass fragmentation of authentic standards. Taken together, the results demonstrate the beneficial effects of nutgalls of R. chinensis and its phytochemicals to manage postmenopausal bone disorders and obesity.

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Section: Resultsmentioning

confidence: 99%

Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet

et al. 2019

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“…Kinases are involved in almost every aspect of physiology. P38 mitogen-activated protein kinase (MAPK) is one of the important enzymes that inhibit the immune system to treat autoimmune diseases [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Application of MIA-QSAR in Designing New Protein P38 MAP Kinase Compounds Using a Genetic Algorithm

Mirshafiei

Niazi‎²,

Yazdanipour³

2023

Period. Polytech. Chem. Eng.

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Multivariate image analysis quantitative structure-activity relationship (MIA-QSAR) study aims to obtain information from a descriptor set, which are image pixels of two-dimensional molecule structures. In the QSAR study of protein P38 mitogen-activated protein (MAP) kinase compounds, the genetic algorithm application for pixel selection and image processing is investigated. There is a quantitative relationship between the structure and the pIC50 based on the information obtained. (The pIC50 is the negative logarithm of the half-maximal inhibitory concentration ( IC50 ), so pIC50 = −log IC50 .) Protein P38 MAP kinase inhibitors are used in the treatment of malignant tumors. The development of a model to predict the pIC50 of these compounds was performed in this study. To accomplish this, the molecules were first plotted and fixed in the same coordinates in ChemSketch. Then, the images were processed in the MATLAB program. Partial least squares (PLS) model, orthogonal signal correction partial least squares (OSC-PLS) model, and genetic algorithm partial least squares (GA-PLS) model methods are used to generate quantitative models, and pIC50 prediction is performed. The GA-PLS model has the highest predictive power for a series of statistical parameters such as root mean square error of prediction (RMSEP) and relative standard errors of prediction (RSEP). Finally, the molecular junction (docking) was done for predicted molecules in quantitative structure activity relationship (QSAR) with an appropriate receptor and acceptable results were obtained. These results are good and proper for the prediction of compounds with better properties.

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“…Estes compostos pertencem à classe dos taninos hidrolisáveis e são amplamente distribuídos no reino vegetal. Os elagitaninos são relatados como mediadores da supressão da osteoclastogênese, enquanto os galotaninos são conhecidos por seus efeitos biológicos como propriedades anticancerígenas, anti-inflamatórias, bem como seu papel protetor contra a aterosclerose, diabetes induzido por dieta gordurosa e nefropatia diabética (HOSOYAMA et al, 2016).…”

Section: Compostos Fenólicosunclassified

Avaliação da composição nutricional, capacidade antioxidante e bioacessibilidade in vitro de compostos fenólicos da uvaia (Eugenia pyriformis Cambess)

de Paulo Farias

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Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway

Cited by 4 publications

References 32 publications

Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet

Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet

Application of MIA-QSAR in Designing New Protein P38 MAP Kinase Compounds Using a Genetic Algorithm

Avaliação da composição nutricional, capacidade antioxidante e bioacessibilidade in vitro de compostos fenólicos da uvaia (Eugenia pyriformis Cambess)

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