Effects of Gadolinium Retention in the Brains of Type 2 Diabetic Rats after Repeated Administration of Gadolinium‐Based MRI Contrast Agents on Neurobiology and NLRP3 Inflammasome Activation
Xiang Yao,
Haoran Zhang,
Jingyi Hu
et al.
Abstract:BackgroundThe neurotoxic potential of gadolinium (Gd)‐based contrast agents (GBCAs) retention in the brains of patients with type 2 diabetes mellitus (T2DM) is unclear.PurposeTo determine the deposition and clearance of GBCAs in T2DM rats and the mechanism by which Gd enhances nucleotide‐binding oligomerization domain‐3 (NLRP3) inflammasome activation.Study TypeCross‐sectional, prospective.Animal Model104 T2DM male Wistar rats.Field Strength/Sequence9.4‐T, T1‐weighted fast spin echo sequence.AssessmentT2DM (ma… Show more
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