Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues

Fernandez, Perla C Reyes; Wright, Christian S; Warden, Stuart J.; Hum, Julia M.; Farach‐Carson, Mary C.; Thompson, William R.

doi:10.1007/s11914-022-00750-x

Cited by 5 publications

(4 citation statements)

References 111 publications

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“…Therefore, gabapentin was once considered an important drug for the treatment of NP syndromes ( 58 , 59 ). Available studies have shown that short-term use (three months) could lead to adverse cardiovascular disease ( 60 ) while long-term use of gabapentin could damage musculoskeletal conditions ( 61 – 63 ). Knowing the potential complications can have a considerable impact on the treatment plan given by the clinician.…”

Section: Discussionmentioning

confidence: 99%

Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis

Gong

Zhu

et al. 2023

Front. Immunol.

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BackgroundNeuropathic pain is caused by a neurological injury or disease and can have a significant impact on people’s daily lives. Studies have shown that neuropathic pain is commonly associated with neurodegenerative diseases. In recent years, there has been a lot of literature on the relationship between neuropathic pain and neurodegenerative diseases. However, bibliometrics is rarely used in analyzing the general aspects of studies on neuropathic pain in neurodegenerative diseases.MethodsThe bibliometric analysis software CiteSpace and VOSviewer were used to analyze the knowledge graph of 387 studies in the Science Citation Index Expanded of the Web of Science Core Collection Database.ResultsWe obtained 2,036 documents through the search, leaving 387 documents after culling. 387 documents were used for the data analysis. The data analysis showed that 330 papers related to neuropathic pain in neurodegenerative diseases were published from 2007–2022, accounting for 85.27% of all published literature. In terms of contributions to the scientific study of neuropathic pain, the United States is in the top tier, with the highest number of publications, citations, and H-indexes.ConclusionThe findings in our study may provide researchers with useful information about research trends, frontiers, and cooperative institutions. Multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease are the three most studied neurodegenerative diseases. Among the pathological basis of neurodegenerative diseases, microglia-regulated neuroinflammation is a hot research topic. Deep brain stimulation and gamma knife radiosurgery are two popular treatments.

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Section: Discussionmentioning

confidence: 99%

Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis

Gong

Zhu

et al. 2023

Front. Immunol.

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“…Therefore, prolonged use of the drug is associated with adverse effects on the musculoskeletal system (Reyes Fernandez et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Prenatal toxicity of gabapentin on bone development in rat offsprings

Değermenci

Uçar

Yılmaz

et al. 2023

Preprint

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Background Gabapentin is a drug commonly prescribed to adult pregnant women with neuropathic pain and epilepsy. Since the effect of antiepileptic drugs used in pregnant women with epilepsy on prenatal bone development is controversial, this study was conducted to demonstrate the toxic effects of gabapentin use during pregnancy on the skeletal system. Methods In the study, pregnant Wistar albino rats were randomly selected and divided into 5 groups (n = 4) as control and 10 mg/kg/day, 30 mg/kg/day, 60 mg/kg/day and 120 mg/kg/day gabapentin groups. The pups were subjected to double skeletal staining (DSS) and the ossification lengths and areas of the fore and hind bones of the pups were measured. Immunohistochemistry (IHC) was used to evaluate the ossification sites and the levels of alkaline phosphatase (AP) and tartrate resistant acid phosphatase (TRAP) immunoreactivity in the pups' femurs. Results: According to the results, the weights and morphometric sizes of the pups were lower than those of the control group. It was found that ossification rates in the fore and hind bones were statistically significantly lower. It was revealed that AP and TRAP intensities which is metabolic markers for bone development were reduced in the experimental groups compared to the control group. Conclusions We have shown that continuous use of gabapentin during pregnancy in rats results in lower birth weight offspring, delayed ossification in the offspring and adverse effects on bone metabolism as the dose increases.

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“…They modulate calcium channels in the central nervous system, which reduces the release of excitatory neurotransmitters, such as glutamate. By diminishing the release of these neurotransmitters, gabapentin and pregabalin help alleviate neuropathic pain, which is characterized by abnormal nerve signaling and sensitivity [ 24 ]. Gabapentin and pregabalin are increasingly utilized as adjuvant analgesics in orthopedic practice, especially for the management of neuropathic pain that may occur postoperatively.…”

Section: Reviewmentioning

confidence: 99%

“…Neuropathic pain can be a challenging aspect of orthopedic surgery, often resulting from nerve compression, injury, or irritation during the procedure. These anticonvulsant agents can be valuable additions to postoperative pain management regimens as they target the specific mechanisms underlying neuropathic pain [ 24 ].…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review of Postoperative Analgesics Used in Orthopedic Practice

Goel,

Deshpande,

Jadawala

et al. 2023

Cureus

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Orthopedic surgeries, ranging from joint replacements to fracture fixations, are integral procedures that enhance the quality of life for countless individuals. Effective postoperative pain management is crucial in ensuring optimal patient recovery and satisfaction. This comprehensive review analyzes the diverse array of analgesic modalities employed in orthopedic practice for postoperative pain relief. The review systematically explores the pharmacological landscape of analgesics commonly used in orthopedic settings, including opioids, non-steroidal anti-inflammatory drugs, acetaminophen, and adjuvant medications. Emphasis is placed on their mechanisms of action, efficacy profiles, and potential adverse effects. Special attention is given to the evolving role of multimodal analgesia, which combines various agents to achieve synergistic pain control while minimizing individual drug-related complications. Furthermore, the review addresses the emerging trends and advancements in postoperative analgesia within orthopedics, such as integrating regional anesthesia techniques, peripheral nerve blocks, and novel pharmacological agents. A critical evaluation of evidence-based practices and recent clinical trials is incorporated to guide practitioners in making informed decisions regarding postoperative pain management. Consideration is also given to the individualized nature of pain experiences and the importance of patient-centric approaches. The review underscores the significance of tailoring analgesic regimens based on patient characteristics, surgical procedures, and potential complications, fostering a personalized and effective pain management strategy. In conclusion, this comprehensive review is valuable for orthopedic practitioners, anesthetists, and healthcare professionals involved in postoperative care. By synthesizing current knowledge and highlighting evolving trends, the review contributes to the ongoing dialogue on optimizing pain management strategies in orthopedic practice, ultimately improving patient outcomes and satisfaction.

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Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues

Cited by 5 publications

References 111 publications

Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis

Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis

Prenatal toxicity of gabapentin on bone development in rat offsprings

A Comprehensive Review of Postoperative Analgesics Used in Orthopedic Practice

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