“…In addition, potential candidates, for which susceptibility loci have been mapped in vicinity to the GABA B R1 gene, i.e., close to the HLA-F gene, include schizophrenia (SCZD3), reading disability (DYX2), and epilepsy [Greenberg et al, 1988;Cardon et al, 1994;Schwab et al, 1995;Straub et al, 1995;Wang et al, 1995;Sander et al, 1997]. Possible clinical applications of GABA B agonists/antagonists include spasticity [Bowery, 1993], epilepsy [Bowery, 1989;Caddick and Hosford, 1996], drug withdrawal [Shoaib et al, 1998;Capasso, 1999], anxiety, depression, and cognitive dysfunction [Kerr and Ong, 1995;Getova et al, 1997].…”