Effects of GABA on gastric acid secretion and ulcer formation in rats

Miñano, F.J.; Serrano, Juan Bautista Vivero; Pascual, Javier; Sancibrián, M.

doi:10.1016/0024-3205(87)90734-x

Cited by 19 publications

(15 citation statements)

References 23 publications

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“…In a study on the effects of GABA on gastric acid secretion and ulcer formation, an oral dose of 100 and 1,000 mg/kg of GABA was administered with no side effects, as GABA is unable to cross the blood-brain barrier, with an anti-ulcer effect stemming from localized action on GABA receptors [11]. On the other hand, we observed a significantly lower average litter size in the treatment groups (50% GBR and GEHD) compared to the HFD group (Table 3).…”

Section: Discussionmentioning

confidence: 99%

In utero Exposure to Germinated Brown Rice and Its GABA Extract Attenuates High-Fat-Diet-Induced Insulin Resistance in Rat Offspring

Adamu

Imam²,

Ooi³

et al. 2017

Lifestyle Genomics

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Background: Numerous studies have reported on the influence of diet on insulin resistance. Our study provides insight into the effect of germinated brown rice (GBR) and γ-aminobutyric acid (GABA) on early environment-driven programming and susceptibility to insulin resistance in rat offspring. Methods: Male rat offspring from female Sprague-Dawley rats fed with a high-fat diet (HFD) alone, HFD + GBR, or HFD + GABA extract throughout pregnancy and lactation were weaned 4 weeks after delivery and followed up for 8 weeks. A biochemical analysis and an assessment of the hepatic expression of insulin signaling genes were performed. Results: The results showed that intrauterine exposure to HFD caused metabolic perturbations in rat offspring which gravitated towards insulin resistance even though the rat offspring did not consume an HFD. GBR and GABA attenuated the HFD-induced changes by underlying regulation of the insulin signaling genes. Conclusions: The results suggest that intake of GBR and GABA during pregnancy and lactation can influence the programming of genes in rat offspring, thereby enhancing insulin sensitivity.

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Section: Discussionmentioning

confidence: 99%

In utero Exposure to Germinated Brown Rice and Its GABA Extract Attenuates High-Fat-Diet-Induced Insulin Resistance in Rat Offspring

Adamu

Imam²,

Ooi³

et al. 2017

Lifestyle Genomics

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“…A non-neuronal, releasable GABA pool has been observed in the rat gastric antrum (Erd6 and Wolff 1988). A role of GABA in gastric acid secretion and ulcer formation, by central or peripheral receptors, has also been suggested (Lloyd et al 1986;Minano et al 1987;Thirlby et al 1988).…”

Section: Functional Implications Of Interactions Between Gaba and Endmentioning

confidence: 99%

Immunocytochemical and autoradiographic studies of the endocrine cells interacting with GABA in the rat stomach

et al. 1990

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There are now increasing evidences suggesting that GABA is able of direct interaction with certain endocrine cells. In the present study, highly specific anti-GABA-glutaraldehyde antibodies and 3H-GABA uptake were used at the light and electron microscope levels to investigate the occurrence of cells containing endogenous GABA or taking up exogenous GABA in the mucosal antrum and corpus of the rat stomach. Only certain endocrine cell types of both regions were immunostained or grain-labelled. However, the morphology of their secretory granules did not allow to identify the nature of their hormone with certainty but suggested that somatostatin-like cells could interact with GABA. The combination of gastrin and somatostatin immunodetection with 3H-GABA uptake autoradiography at the light microscope level, revealed that a subpopulation of somatostatin-like cells and other still unidentified endocrine cells are able to take up GABA, while the gastrin-like cells are not. These results rei... Summary. There are now increasing evidences suggesting that GABA is able of direct interaction with certain endocrine cells. In the present study, highly specific anti-GABAglutaraldehyde antibodies and aH-GABA uptake were used at the light and electron microscope levels to investigate the occurrence of cells containing endogenous GABA or taking up exogenous GABA in the mucosal antrum and corpus of the rat stomach. Only certain endocrine cell types of both regions were immunostained or grain-labelled. However, the morphology of their secretory granules did not allow to identify the nature of their hormone with certainty but suggested that somatostatin-like cells could interact with GABA. The combination of gastrin and somatostatin immunodetection with aH-GABA uptake autoradiography at the light microscope level, revealed that a subpopulation of somatostatin-like cells and other still unidentified endocrine cells are able to take up GABA, while the gastrin-like cells are not. These results reinforce the hypothesis that certain endocrine cell types of the diffuse endocrine system of the digestive tract are able to directly interact with GABA.

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“…The severity score was assigned according to Minano et al (1987). Score 0, no pathological changes; Score 1, mucosal oedema and petechial haemorrhages; Score 2, 1-5 small ulcers (1 -2mm); Score 3, more than 5 small ulcers or 1 medium ulcer (3 -4mm); Score 4, more than 2 medium ulcers or 1 large ulcer (more than 4 mm) and Score 5, perforated ulcers.…”

Section: Macroscopic and Histopathological Analysismentioning

confidence: 99%

Anti-ulcerogenic activity of virgin coconut oil contribute to the stomach health of humankind

Selverajah¹,

Zakaria²,

Long³

et al. 2016

TANG [HUMANITAS MEDICINE]

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The aimed of the presence study was to determine the antiulcer potential of virgin coconut oil (VCO), either extracted by wet process (VCO A ) or fermentation process (VCO B ), and to compare their effectiveness against the copra oil (CO) using the HCl/ethanol-induced gastric ulcer model. Earlier, the oils underwent chemical analysis to determine the free fatty acids composition, physicochemical properties and anti-oxidant capability. In the antiulcer study, rats (n = 6) were pre-treated orally for 7 consecutive days with distilled water (vehicle), 100 mg/kg ranitidine (positive group) or the respective oils (10, 50, and 100% concentration). One hour after the last test solutions administration on Day 7 th , the animals were subjected to the gastric ulcer assay. Macroscopic and microscopic analyses were performed on the collected rat's stomachs. From the results obtained, the chemical analysis revealed i) the presence of high content of lauric acid followed by myristic acid and palmitic acid in all oils and; ii) the significant ( * p < 0.05) different in anisidine-and peroxide-value, percentage of free fatty acid, total phenolic content and total antioxidant activity among the oils. The animal study demonstrated that all oil possess significant ( * p < 0.05) antiulcer activity with VCO B being the most effective oil followed by VCO A and CO. The macroscopic observations were supported by the microscopic findings. Interestingly, all oils were more effective than 100 mg/kg ranitidine (reference drug). In conclusion, coconut oils exert remarkable antiulcer activity depending on their methods of extraction, possibly via the modulation of its antioxidant and anti-inflammatory activity.

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Effects of GABA on gastric acid secretion and ulcer formation in rats

Cited by 19 publications

References 23 publications

In utero Exposure to Germinated Brown Rice and Its GABA Extract Attenuates High-Fat-Diet-Induced Insulin Resistance in Rat Offspring

In utero Exposure to Germinated Brown Rice and Its GABA Extract Attenuates High-Fat-Diet-Induced Insulin Resistance in Rat Offspring

Immunocytochemical and autoradiographic studies of the endocrine cells interacting with GABA in the rat stomach

Anti-ulcerogenic activity of virgin coconut oil contribute to the stomach health of humankind

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