Effects of fucoxanthin on autophagy and apoptosis in SGC‐7901cells and the mechanism

Zhu, Yue; Cheng, Jun; Zhou, Min; Yin, Tingzi; Zhang, Rong; Zhang, Wei; Hu, Ling; Cui, Zhiwen; Gao, Chengzhi; Xu, Shunqing; Zhang, Chunxiang; Hu, Xingjian

doi:10.1002/jcb.27022

Cited by 34 publications

(20 citation statements)

References 31 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data obtained in the present study suggested that vortioxetine inactivated the PI3K/AKT pathway by decreasing the phosphorylation levels of AKT and mTOR, as well as cyclin D1. Indeed, correlations have been demonstrated between apoptosis and autophagy; for example, the promotion of autophagy could enhance the apoptosis of GC cells [45,46]. Hence, we speculated that vortioxetine induced apoptosis and autophagy via activation of the PI3K/AKT pathway in GC cells.…”

Section: Discussionmentioning

confidence: 90%

Vortioxetine induces apoptosis and autophagy of gastric cancer AGS cells via the PI3K/AKT pathway

Wang

Zhu

et al. 2020

FEBS Open Bio

View full text Add to dashboard Cite

Vortioxetine is a potent antagonist of the 5-hydroxytryptamine receptor and serotonin transporter and has been reported to function as an antidepressant in the treatment of major depressive disorder. However, its antitumor effects remain unclear. Here, we examined whether vortioxetine affects the characteristics of GC cells. Cell viability was measured by a colony formation assay and, in addition, cell invasion, migration and apoptosis assays were performed with a transwell assay and a flow cytometry assay. Protein levels were measured by western blotting. We found that vortioxetine inhibited the proliferation, invasion and migration abilities of AGS cells. Additionally, vortioxetine could induce apoptosis and autophagy by increasing the levels of Bax, active caspase-3/-9, Beclin-1 and light chain 3, as well as by downregulating Bcl-2 and P62. Further investigations indicated that vortioxetine regulated apoptosis and autophagy via activation of the phosphoinositide 3-kinase/AKT pathway. Taken together, our data suggest that vortioxetine has cytotoxic effects against GC AGS cells as a result of inhibiting proliferation, invasion and migration, as well as by inducing apoptosis and autophagy through the phosphoinositide 3-kinase/ AKT pathway.

show abstract

Section: Discussionmentioning

confidence: 90%

Vortioxetine induces apoptosis and autophagy of gastric cancer AGS cells via the PI3K/AKT pathway

Wang

Zhu

et al. 2020

FEBS Open Bio

View full text Add to dashboard Cite

show abstract

“…The same pro-apoptotic effect caspase-mediated was also observed in human bladder cancer cells, in human cervical cancer cells HeLa [216]; in human breast cancer cells MCF-7 and in estrogen-resistant cells MDA-MB-231 [204]. In gastric cancer SGC-7901 cells, fucoxanthin induced autophagy, which in turn promoted apoptosis with caspase-3 cleavage and Bcl-2 downregulation [217]. There is some evidence showing that fucoxanthin could be used to potentiate the action of conventional anticancer drugs.…”

Section: Marine-derived Compounds: Inductors Of Apoptosismentioning

confidence: 76%

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

2019

View full text Add to dashboard Cite

Natural compounds derived from marine organisms exhibit a wide variety of biological activities. Over the last decades, a great interest has been focused on the anti-tumour role of sponges and algae that constitute the major source of these bioactive metabolites. A substantial number of chemically different structures from different species have demonstrated inhibition of tumour growth and progression by inducing apoptosis in several types of human cancer. The molecular mechanisms by which marine natural products activate apoptosis mainly include (1) a dysregulation of the mitochondrial pathway; (2) the activation of caspases; and/or (3) increase of death signals through transmembrane death receptors. This great variety of mechanisms of action may help to overcome the multitude of resistances exhibited by different tumour specimens. Therefore, products from marine organisms and their synthetic derivates might represent promising sources for new anticancer drugs, both as single agents or as co-adjuvants with other chemotherapeutics. This review will focus on some selected bioactive molecules from sponges and algae with pro-apoptotic potential in tumour cells.

show abstract

“…The results pointed out the importance of a combination drug therapy approach within cancer research [ 149 ]. Moreover, fucoxanthin inhibited viability, induced autophagy and apoptosis through upregulation of beclin-1, microtubule-associated proteins 1A/1B light chain 3 (LC3), and cleaved caspase-3, and downregulation of Bcl-2 in SGC7901 gastric cancer cells [ 150 ]. Furthermore, fucoxanthin activated apoptosis via inhibition of PI3K/Akt/mTOR pathway in U87 and U251 human glioma cancer cells [ 151 ] and induced apoptosis in adenocarcinoma SGC-7901 or BGC-823 human gastric cells involving downregulation of Mcl-1, STAT3 and p-STAT3 [ 152 ].…”

Section: The Use Of Carotenoids In Preclinical Cancer Researchmentioning

confidence: 99%

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

Koklesová

Líšková

Samec

et al. 2020

Cancers

View full text Add to dashboard Cite

An incidence and mortality of cancer are rapidly growing worldwide, especially due to heterogeneous character of the disease that is associated with irreversible impairment of cellular homeostasis and function. Targeting apoptosis, one of cancer hallmarks, represents a potent cancer treatment strategy. Carotenoids are phytochemicals represented by carotenes, xanthophylls, and derived compounds such as apocarotenoids that demonstrate a broad spectrum of anti-cancer effects involving pro-apoptotic signaling through extrinsic and intrinsic pathways. As demonstrated in preclinical oncology research, the apoptotic modulation is performed at post-genomic levels. Further, carotenoids demonstrate additive/synergistic action in combination with conventional oncostatic agents. In addition, a sensitization of tumor cells to anti-cancer conventional treatment can be achieved by carotenoids. The disadvantage of anti-cancer application of carotenoids is associated with their low solubility and, therefore, poor bioavailability. However, this deficiency can be improved by using nanotechnological approaches, solid dispersions, microemulsions or biofortification that significantly increase the anti-cancer and pro-apoptotic efficacy of carotenoids. Only limited number of studies dealing with apoptotic potential of carotenoids has been published in clinical sphere. Pro-apoptotic effects of carotenoids should be beneficial for individuals at high risk of cancer development. The article considers the utility of carotenoids in the framework of 3P medicine.

show abstract

Effects of fucoxanthin on autophagy and apoptosis in SGC‐7901cells and the mechanism

Cited by 34 publications

References 31 publications

Vortioxetine induces apoptosis and autophagy of gastric cancer AGS cells via the PI3K/AKT pathway

Vortioxetine induces apoptosis and autophagy of gastric cancer AGS cells via the PI3K/AKT pathway

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

Contact Info

Product

Resources

About