Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines

Abudabbus, Aisha; Badmus, Jelili A.; Shalaweh, Salem; Bauer, Rolene; Hiss, Donavon C

doi:10.2174/1389201018666171115115112

Cited by 27 publications

(23 citation statements)

References 454 publications

(682 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies reported that fucoidan exhibits several anticancer effects, including induction of apoptosis and inhibition of tumor-induced angiogenesis [128,129]. Effects on hepatocarcinoma and melanoma cancer have been reported, as well as in bladder, breast, colon, liver, lung, and prostate cells [130,131].…”

Section: Anticancer Activitymentioning

confidence: 99%

Seaweeds as a Functional Ingredient for a Healthy Diet

Lorenzo²,

et al. 2020

View full text Add to dashboard Cite

Seaweeds have been used since ancient times as food, mainly by Asian countries, while in Western countries, their main application has been as gelling agents and colloids for the food, pharmaceuticals, and the cosmetic industry. Seaweeds are a good source of nutrients such as proteins, vitamins, minerals, and dietary fiber. Polyphenols, polysaccharides, and sterols, as well as other bioactive molecules, are mainly responsible for the healthy properties associated with seaweed. Antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic properties are attributed to these compounds. If seaweeds are compared to terrestrial plants, they have a higher proportion of essential fatty acids as eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids. In addition, there are several secondary metabolites that are synthesized by algae such as terpenoids, oxylipins, phlorotannins, volatile hydrocarbons, and products of mixed biogenetic origin. Therefore, algae can be considered as a natural source of great interest, since they contain compounds with numerous biological activities and can be used as a functional ingredient in many technological applications to obtain functional foods.

show abstract

Section: Anticancer Activitymentioning

confidence: 99%

Seaweeds as a Functional Ingredient for a Healthy Diet

Lorenzo²,

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Recent proven study in mainstream of MCF-7 breast cancer cells has been implied that the fucoidan can be a promising candidate for cancer therapy in combination of the cisplatin, doxorubicin and taxol [22]. Further, fucoidan induced apoptosis in PC-3 human prostate cancer cells has also been well documented [23].…”

Section: Introductionmentioning

confidence: 99%

Anticancer effect of fucoidan on cell proliferation, cell cycle progression, genetic damage and apoptotic cell death in HepG2 cancer cells

Arumugam¹,

Arunkumar²,

Loganathan³

et al. 2019

Toxicology Reports

View full text Add to dashboard Cite

show abstract

“…They also reported that the combination of fucoidan and cisplatin was the most effective one [47]. The results have been confirmed by Abuddabus et al, who found that simultaneous incubation of cisplatin, doxorubicin or paclitaxel with fucoidan magnified therapeutic effects when compared to single agents [48]. A synergy between fucoidan and lapatinib has also been reported [49].…”

Section: Discussionmentioning

confidence: 78%

Fucoidan Exerts Anticancer Effects Against Head and Neck Squamous Cell Carcinoma In Vitro

et al. 2018

View full text Add to dashboard Cite

Fucoidans have been reported to exert anticancer effects with simultaneous low toxicity against healthy tissue. That correlation was observed in several cancer models, however, it has never been investigated in head and neck cancer before. To magnify the efficacy of conventional therapy, the administration of agents like fucoidan could be beneficial. The aim of this study was to evaluate the anticancer effect of Fucus vesiculosus (FV) extract alone and with co-administration of cisplatin in head and neck squamous cell carcinoma (HNSCC) in vitro. MTT assay results revealed an FV-induced inhibition of proliferation in all tested cell lines (H103, FaDu, KB). Flow cytometric cell cycle analysis showed an FV-induced, dose-dependent arrest in either S/G2 phase (H103, FaDu) or G1 arrest (KB). Furthermore, a dose-dependent gain in apoptotic fraction was observed. Western blot analysis confirmed the induction of apoptosis. A significant dose-dependent increase in reactive oxygen species (ROS) production was revealed in the H103 cell line, while FaDu cells remained unresponsive. On the contrary, an HPV-positive cell line, KB, demonstrated a dose-dependent decrease in ROS synthesis. Moreover, fucoidan enhanced the response to cisplatin (synergistic effect) in all cell lines with the HPV-positive one (KB) being the most sensitive. These results have been confirmed by flow-cytometric apoptosis analysis. In conclusion, we confirmed that fucoidan exhibits anticancer properties against HNSCC, which are manifested by the induction of apoptosis, regulation of ROS production, cell cycle arrest, and inhibition of proliferation.

show abstract

Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines

Cited by 27 publications

References 454 publications

Seaweeds as a Functional Ingredient for a Healthy Diet

Seaweeds as a Functional Ingredient for a Healthy Diet

Anticancer effect of fucoidan on cell proliferation, cell cycle progression, genetic damage and apoptotic cell death in HepG2 cancer cells

Fucoidan Exerts Anticancer Effects Against Head and Neck Squamous Cell Carcinoma In Vitro

Contact Info

Product

Resources

About