Effects of Fructooligosaccharides on the Absorption of Iron, Calcium and Magnesium in Iron-deficient Anemic Rats.

Ohta, Atsutane; Ohtsuki, Masako; Baba, Seigo; Takizawa, Toshio; Adachi, Takashi; Kimura, Shuichi

doi:10.3177/jnsv.41.281

Cited by 164 publications

(130 citation statements)

References 21 publications

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“…Iron deficiency is a common problem in veal calves fed only milk replacer and no solid feed or fiber-rich supplementation (Cozzi et al, 2002). Inulin feeding could have had improving effects on iron absorption capabilities as was shown previously in rats (Ohta et al, 1995).…”

Section: Discussionmentioning

confidence: 79%

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Masanetz

Preißinger

Meyer

et al. 2011

Animal

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Prebiotics are suggested as an alternative to antibiotics in animal rearing. Fermentable substances such as inulin or lactulose have been proposed to stimulate the immune system and health by modulation of the intestinal flora and its fermentation products. In this study, effects of inulin and lactulose on the intestinal health and hematology of calves have been investigated. Both prebiotics significantly decreased thrombocyte counts in peripheral blood. Only inulin was able to increase hemoglobin concentration and hematocrit. Total leukocyte count was decreased by lactulose while both prebiotics tended to lower monocyte proportions. mRNA expression of inflammation-related markers in the intestine was also affected by both prebiotics hinting at a decreased inflammatory status. This may be due to a possible decrease in intestinal pathogen load that remains to be verified. Only mRNA amounts of interleukin 8 were increased by lactulose in mesenteric lymph nodes. In the ileum, expression of a proliferation marker was increased by inulin while an apoptosis-related gene was increased by both prebiotics. The results of this study show a clear effect of prebiotics on certain parameters associated with animal health and performance that remain to be studied in detail in future investigations.

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Section: Discussionmentioning

confidence: 79%

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Masanetz

Preißinger

Meyer

et al. 2011

Animal

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“…It has been demonstrated that the stimulatory effects of FOS and other indigestible carbohydrates on calcium absorption occur in the large intestine (26)(27)(28). However, the detailed mechanism involved has not yet been clarified.…”

Section: Fos and Mineral Absorptionmentioning

confidence: 99%

The Effect on Bone of Stimulated Intestinal Mineral Absorption Following Fructooligosaccharide Consumption in Rats

Morohashi

2002

Bioscience Microflora

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Several studies have been carried out to establish the role of calcium and magnesium in bone. These minerals may play an important role in bone structure or strength. Fructooligosaccharides (FOS) are known to be stimulators of intestinal mineral absorption. In intact rats, bone volume and the mineral content (Ca, and Mg ) of the bone surface are greater in FOS-fed rats. Moreover, a significant relationship exists between the absorption of these minerals and their content in bone. Osteopenia is known to follow total gastrectomy in animals, leading to the severe concordant loss of both cortical and cancellous bone. These findings are similar to senile osteoporosis in humans. Dietary FOS completely prevents the gastrectomy-induced osteopenia in rats. If similar effects are found in humans, an increase in mineral deposition in bone during growth may contribute to the prevention of bone disease with age. Thus FOS might be a promising prebiotic for bone.

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“…First, indigestible carbohydrates reach the large intestine intact and free from enzymatic digestion and are fermented by enteric bacteria to produce organic acids such as acetate, propionate, and butyrate (18,32). Although these acids have important physiological effects in their own right, they also act to lower the pH of the lumen.…”

Section: Increased Calcium Absorption With Fos Occurs In the Large Inmentioning

confidence: 99%

“…Despite this major expansion in knowledge, the mechanisms of absorption for calcium in the intestine has remained unclear. As a nutritional element, fructooligosaccharides (FOS) were found to increase calcium absorption (32,33). An investigation of this effect would therefore be very likely to contribute to the study of calcium absorption.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanism of the Effect of Fructooligosaccharides on Calcium Absorption

Sakuma

2002

Bioscience Microflora

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Previous reports have demonstrated through the use of animal models that dietary fructooligosaccharides (FOS) exert stimulatory effects on the absorption of the minerals; calcium, magnesium, and iron. Recently, these effects were also clinically confirmed in humans. This paper reviews studies that used the techniques of molecular biology to elucidate the mechanisms by which FOS stimulates calcium absorption for which the small intestine has long been considered a primary site. However, Ohta et al. reported that the large intestine, and the cecum in particular, has an important role. This conclusion was based on the observation that the stimulatory effect of FOS on calcium absorption was not observed in cecectomized rats. The contribution of paracellular and transcellular paths was suggested for the stimulation caused by FOS. Transcellular transport is a multistep process comprising several components and is under the regulation of vitamin D. One component is calbindin-D9k (CaBP), a calcium binding protein. The upstream region of the CaBP gene was analyzed, and a responsive sequence for vitamin D receptor was identified. Mucosal cells were then obtained from FOS-fed rats, and the expression of CaBP protein and mRNA were determined. Dietary FOS decreased the expression of CaBP in the small intestine, but resulted in increased levels in the cecum and colorectum. Since protein and mRNA both demonstrated similar patterns of expression, the effects of FOS can be seen to affect CaBP at the transcription level. Furthermore, the changes in CaBP expression were proportional to both the level of apparent calcium absorption and the amount of FOS ingested. This means that the increase of calcium absorption induced by FOS comprises paracellular and CaBP-mediated transcellular transport. In a hypothetical model, short-chain organic acids produced from FOS by fermentation were proposed as key elements to regulate both the paracellular and the transcellular transport of calcium. However, the molecular mechanisms of this regulation have not yet been clarified.

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Effects of Fructooligosaccharides on the Absorption of Iron, Calcium and Magnesium in Iron-deficient Anemic Rats.

Cited by 164 publications

References 21 publications

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

The Effect on Bone of Stimulated Intestinal Mineral Absorption Following Fructooligosaccharide Consumption in Rats

Molecular Mechanism of the Effect of Fructooligosaccharides on Calcium Absorption

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