Effects of formulation variables on characteristics of poly (ethylcyanoacrylate) nanocapsules prepared from w/o microemulsions

Watnasirichaikul, Suchat; Rades, Thomas; Tucker, Ian G.; Davies, Nigel

doi:10.1016/s0378-5173(02)00002-9

Cited by 52 publications

(24 citation statements)

References 20 publications

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“…1). Generally, the polymer shell surrounding the liquid core is formed thanks to polymerization taking place at the interface between the dispersed and continuous phase of the emulsion (18)(19)(20)(21)(22)(23)(24)(25)(26) or by precipitation of a preformed polymer at the surface of emulsion droplets (27)(28)(29)(30).…”

Section: Nanocapsules and Nanospheres: Definitions And Structural Feamentioning

confidence: 99%

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Methods for the Preparation and Manufacture of Polymeric Nanoparticles

2008

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This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules. The first part summarizes the basic principle of each method of nanoparticle preparation. It presents the most recent innovations and progresses obtained over the last decade and which were not included in previous reviews on the subject. Strategies for the obtaining of nanoparticles with controlled in vivo fate are described in the second part of the review. A paragraph summarizing scaling up of nanoparticle production and presenting corresponding pilot set-up is considered in the third part of the review. Treatments of nanoparticles, applied after the synthesis, are described in the next part including purification, sterilization, lyophilization and concentration. Finally, methods to obtain labelled nanoparticles for in vitro and in vivo investigations are described in the last part of this review.

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Section: Nanocapsules and Nanospheres: Definitions And Structural Feamentioning

confidence: 99%

“…Water-containing nanocapsules are mostly prepared from inverse emulsions and inverse microemulsions (19,20,24,39,108,129,130). Generally, the emulsions or the microemulsions are prepared without incorporating the monomer which is added to the continuous phase after preparation of the formulation.…”

Section: Polymerization Of Alkylcyanoacrylatesmentioning

confidence: 99%

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

2008

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“…Synthetic polymers and natural polymer materials are used to prepare nano-drug carriers. Examples of synthetic polymers include polyester-based aliphatic polyesters, aromatic polyesters, polycarbonates, polyanhydrides and polyamides (Panagi et al, 2001;Watnasirichaikul et al, 2002). Synthetic macromolecular materials can synthesize the desired product according to the specific need and can be modified to control the characteristics, yielding a product that is highly purified, non-toxic and readily degradable in vivo.…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vitro/in vivo evaluation of resveratrol-loaded carboxymethyl chitosan nanoparticles

Zhang

Wang

et al. 2014

Drug Delivery

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Resveratrol (RES) is natural polyphenol with a strong biological activity, but its disadvantages, such as poor water solubility, susceptibility to oxidative decomposition and rapid metabolism in the body, which substantially restricts in vivo bioavailability, need to be resolved. This study used carboxymethyl chitosan (CMCS) as a drug carrier and utilized emulsion cross-linking to prepare RES-loaded CMCS nanoparticles (RES-CMCSNPs). A single-factor experiment was performed to optimize the preparation of these particles; in vitro and in vivo characteristics were evaluated. Spherical RES-CMCSNPs were prepared under optimal conditions, in which average particle size, potential, drug loading and encapsulation efficiency were (155.3 ± 15.2) nm, (À10.28 ± 6.4) mV, (5.1 ± 0.8)% and (44.5 ± 2.2)%, respectively. FTIR, DSC and XRD showed that RES molecules were wrapped in the nanoparticles. In vitro DPPH radical scavenging abilities showed RES-CMCSNPs were better than RES raw powder. The nanoparticles improved the solubility of RES, thereby greatly improving the antioxidant activity of the drug. In vitro release experiments of RES and RES-CMCSNPs by simulating the human gastrointestinal tract were performed, in which RES-CMCSNPs rendered better releasing effects than raw RES. Raw RES and RES-CMCSNPs results were in line with those obtained for the single-chamber model for pharmacokinetic studies in rats. Compared with the bulk drugs, the RES-CMCSNPs exhibited increased in vivo absorption, prolonged duration of action and increased relative bioavailability by 3.516 times more than those of the raw RES. In addition, the residual chloroform is less than the ICH limit for class 2 solvents.

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“…Em contato com a água, o óleo insolubilizase, formando uma dispersão coloidal, e o solvente orgânico polar difunde-se para a fase externa aquosa. Os monômeros orientamse segundo a sua polaridade na interface O/A, desencadeando-se a polimerização aniônica à superfície das gotículas de óleo, o que conduz à formação da parede das nanocápsulas [29] . Gasco et al, 1991 [30] preparou, por polimerização interfacial em emulsões e em microemulsões invertidas (A/O), nanocápsulas com núcleo aquoso para incorporar princípios ativos hidrofílicos.…”

Section: Nanocápsulasunclassified

“…A vantagem das nanocápsulas de núcleo aquoso diz respeito ao fato do princípio ativo não se encontrar apenas adsorvido, mas sim incorporado, permitindo uma melhor proteção após a administração in vivo. Em qualquer um dos casos, o solvente orgânico é evaporado a pressão reduzida e as nanocápsulas são separadas por centrifugação ou por ultracentrifugação e lavadas com água deionizada [29] . As características fisico-químicas das nanocápsulas obtidas a partir de reações de polimerização de cianoacrilatos de alquilo em emulsões do tipo O/A são afetadas por um conjunto de parâmetros tecnológicos, que incluem a solubilidade do princípio ativo, o pH do meio de polimerização, a natureza e o volume do óleo, a natureza do solvente orgânico e a concentração do tensoativo.…”

Section: Nanocápsulasunclassified

Preparação de nanopartículas poliméricas a partir da polimerização de monômeros: parte I

2012

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Resumo: Nanopartículas poliméricas produzidas a partir de polímeros sintéticos, como copolímeros do ácido metacrílico, ésteres acrílicos ou metacrílicos, têm sido amplamente utilizadas na área farmacêutica para encapsulação de princípios ativos. Essas nanopartículas apresentam as vantagens de proteção, liberação controlada, melhor biodisponibilidade e menor toxicidade, proporcionando maior conforto aos pacientes e adesão ao tratamento. A produção das nanopartículas (nanocápsulas e nanosferas) por polimerização de monômeros é revisada e descrita neste artigo, evidenciando os parâmetros tecnológicos que interferem nas características físico-químicas das nanopartículas, como a solubilidade do princípio ativo, o volume e pH do meio de polimerização, a massa molar e concentração do monômero e a natureza e concentração do tensoativo. Palavras-chave: Nanocápsulas, nanoesferas, polímeros, polimerização de monômeros. Preparation of Polymeric Nanoparticles by Polymerization of Monomers -Part IAbstract: Polymeric nanoparticles obtained from synthetic polymers such as copolymers of methacrylic acid, acrylic esters or metacrylics, have been widely used in pharmaceuticals for encapsulation of drugs. These nanoparticles have the advantages of drug protection, controlled release, improved bioavailability and lower toxicity, resulting in greater comfort to patients and compliance to the treatment. The production of nanoparticles (nanospheres and nanocapsules) by polymerization of monomers is reviewed and discussed in this article, highlighting the technological parameters that affect the physicochemical characteristics of nanoparticles, e.g. drug solubility, phase volume, pH of polymerization, molecular weight and monomer concentration, and the nature and concentration of the surfactant. Keywords: Nanocapsules, nanospheres, polymer, polymerization of monomers. IntroduçãoNanopartículas poliméricas podem apresentar-se na forma de nanocápsulas ou nanoesferas [1][2][3] . As nanocápsulas são constituídas por um invólucro polimérico disposto ao redor de um núcleo oleoso, podendo o fármaco estar dissolvido neste núcleo e/ou adsorvido à parede polimérica. As nanosferas não contêm óleo na sua formulação, mas são formadas por uma matriz polimérica, onde o fármaco pode ficar retido ou adsorvido [4] . As nanopartículas poliméricas são empregadas como veículos de fármacos [5] , proteínas e antigênios [6] para administração injetável [7] , oral [8] , tópico [9] , sistemas bioadesivos, e como o principal componente de sistemas de liberação controlada na forma de implantes [10] . Os polímeros biodegradáveis empregados na produção de nanopartículas poliméricas por polimerização de monômeros são copolímeros do ácido metacrílico e de éster acrílico ou metacrílico [11] . A composição polimérica (hidrofobicidade, carga superficial, perfil de degradação) e do princípio ativo encapsulado (massa molar, carga, localização na nanosfera, absorção ou incorporação) influenciam na biodisponibilidade [1] , sendo a degradação polimérica realizada por esterases...

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Effects of formulation variables on characteristics of poly (ethylcyanoacrylate) nanocapsules prepared from w/o microemulsions

Cited by 52 publications

References 20 publications

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

Preparation and in vitro/in vivo evaluation of resveratrol-loaded carboxymethyl chitosan nanoparticles

Preparação de nanopartículas poliméricas a partir da polimerização de monômeros: parte I

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