Effects of foraging demand on maternal behaviour and adult offspring anxiety and stress response in C57BL/6 mice

Coutellier, Laurence; Friedrich, Anne-Christin; Failing, Klaus; Marashi, Vera; Würbel, Hanno

doi:10.1016/j.bbr.2008.08.042

Cited by 35 publications

(22 citation statements)

References 46 publications

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“…an unpredictable stressor) maternal care was more active and intense when compared with control mothers in low foraging demand conditions, consistent with a maternal mediation model. However, offspring anxiety-like behavior as adults was varying across gender and condition, with male and female mice responding to environmental cues differentially regardless of overall amounts of maternal care [44]. Similar effects were observed in predation threat paradigms, in which rodent mothers are exposed to predator cues.…”

Section: Discussionmentioning

confidence: 69%

“…We cannot comment more extensively on the role of maternal care in this paradigm as we did not systematically vary the amount of maternal care provided to the offspring; we simply 'controlled' for the amount of maternal care received. As mentioned above, while maternal effects on offspring behavior and physiology have been shown extensively in the literature, environmental effects on offspring have also been demonstrated to occur independent of the mother [44].…”

Section: Discussionmentioning

confidence: 97%

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Influence of housing variables on the development of stress-sensitive behaviors in the rat

Sakhai

Preslik

Francis

2013

Physiology & Behavior

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• Laboratory bedding material inuences developmental programming of rats.• Bedding material during early life can alter stress sensitive measures in adulthood.• Corncob bedding during sensitive periods decreases adult measures of anxiety.• Bedding material during adulthood does not affect adult anxiety-like behavior. Diverse environments early in mammalian life can have profound inuences on the physiology and behavior of developing offspring. Environmental factors can inuence offspring development directly or through perturbations in parental care. In the current study, we wished to determine if the inuence of a single environmental variable, type of bedding material used in laboratory cages, is capable of altering physiological and behavioral outcomes in offspring. Female rats were housed in cages containing wood pulp or corncob bedding and allowed to mature. These rats, while housed on assigned bedding material, were bred and allowed to give birth. At weaning, male offspring were housed on one of the two bedding conditions and tested later in adulthood on stress-sensitive behavioral measures. Postmortem analysis of glucocorticoid receptor expression and CRH mRNA levels were also measured. Maternal care directed at the pups reared in the two different bedding conditions was also recorded. Rats reared from birth on corncob bedding exhibited decreased anxiety-like behavior, as adults, in both open eld and light-dark box tasks compared to wood pulp reared animals. Animals that received similar overall levels of maternal care, regardless of bedding condition, also differed in anxiety-like behaviors as adults, indicating that the bedding condition is capable of altering phenotype independent of maternal care. Despite observed behavioral differences in adult offspring reared in different bedding conditions, no changes in glucocorticoid receptor expression at the level of the hippocampus, frontal cortex, or corticotrophin releasing hormone (CRH) mRNA expression in the hypothalamus were observed between groups. These results highlight the importance of early life housing variables in programming stress-sensitive behaviors in adult offspring. a b s t r a c t a r t i c l e i n f oPublished by Elsevier Inc.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 97%

Influence of housing variables on the development of stress-sensitive behaviors in the rat

Sakhai

Preslik

Francis

2013

Physiology & Behavior

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“…Tests were chosen in order to assess locomotor activity in the open-field (Walsh and Cummins, 1976), level of anxiety in the Omaze (Sheperd et al, 1994;Coutellier et al, 2009), short-term memory in the novel object recognition test (Ennaceur and Delacour, 1988;Dudchenko, 2004;Ennaceur, 2010;Moore et al, 2013), muscular strength in the wire mesh hang (Kondziela, 1964) and the grip strength tests (Maurissen et al, 2003), locomotor coordination in the rotarod test (Pratte et al, 2011), depression in the tail suspension test (Steru et al, 1985), and pain sensitivity in the hot plate test (Espejo and Mir, 1993).…”

Section: Behavioural and Motor Testingmentioning

confidence: 99%

“…The level of animal anxiety was assessed by the elevated O-maze test (Sheperd et al, 1994), with the advantage of the lack of the ambiguous central square compared to the traditional plus-maze (Coutellier et al, 2009). The maze was elevated to a 70cm height, with 2 open (50x10cm) and 2 closed (50x10x40cm) arms.…”

Section: Elevated O-mazementioning

confidence: 99%

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity

et al. 2017

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Nonlinear dose-response of aluminium hydroxide adjuvant particles: selective low dose neurotoxicity.Toxicology http://dx.doi.org/10.1016/j.tox. 2016.11.018 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. An unusual neuro-toxicological pattern limited to a low dose of Alhydrogel ® was observed.Neurobehavioural changes, including decreased activity levels and altered anxiety-like behaviour, were observed compared to controls in animals exposed to 200 µg Al/kg but not at 400 and 800 µg Al/kg. Consistently, microglial number appeared increased in the ventral forebrain of the 200 µg Al/kg group. Cerebral Al levels were selectively increased in animals exposed to the lowest dose, while muscle granulomas had almost completely disappeared at 6 months in these animals.We conclude that Alhydrogel® injected at low dose in mouse muscle may selectively induce long-term Al cerebral accumulation and neurotoxic effects. To explain this unexpected result, an avenue that could be explored in the future relates to the adjuvant size since the injected suspensions corresponding to the lowest dose, but not to the highest doses, exclusively contained small agglomerates in the bacteria-size range known to favour capture and, presumably, transportation by monocyte-lineage cells. In any event, the view that Alhydrogel® neurotoxicity obeys "the dose makes the poison" rule of classical chemical toxicity appears overly simplistic.

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“…The bars show means ± SE and **over the bars indicate significant group differences at p < 0.01. the maternal environment are introduced at critical points during development (Curley and Champagne, 2016). Laboratory studies in uniparental species such as rats and mice have shown that when the mother is confronted with foraging demands, removal of nesting materials or predator threats, she alters her nest attendance and active maternal care thus changing the activity of her offspring hypothalamic-pituitary-adrenal (HPA) axis in a sexspecific manner (Ivy et al, 2008;Coutellier et al, 2009;Mashoodh et al, 2009). Hence, it is possible that the behavior of prairievole mothers in our study altered her adult sons' stress responses.…”

Section: Discussionmentioning

confidence: 99%

Socio-Ecological Disruptions at Critical Periods During Development Alter Stress Responses and Hippocampal Dendritic Morphology of Prairie Voles: Implications for Social Monogamy

et al. 2018

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Emotions are often associated with the evolution of monogamy. For example, fear of cuckoldry has been recently proposed as the driving force for human monogamy. We used prairie voles (Microtus ochrogaster) as a model of human behavior to study how stress reactivity is shaped by socio-ecological disruptions experienced as neonates and as subadults. We hypothesized that social disruptions would have a greater impact on the vole's stress levels than ecological disruptions, and that females would be more susceptible to the experience than males. At 6 days postpartum, the housing conditions were manipulated to have offspring raised by: (1) both parents under a protective cover (NoDisrupt); (2) Both parents uncovered (EcoDisrupt); (3) Mother alone covered (SocDisrupt); (4) Mother alone uncovered (SocEcoDisrupt). To experience disruptions as subadults, offspring were weaned then housed either alone (Isolate) or with a same-sex sibling (Social). As adults, each offspring was placed in an open-field arena and tested over 3 consecutive days to measure its behavior in response to an empty space (Day1), a same-sex vole in a container (Day2), and an empty container (Day3). The brain of a subgroup of subjects was processed for Golgi staining to assess the impact of disruptions on hippocampal dendritic morphology in adulthood. Males that experienced social disruption in early life displayed lower stress levels on Day2 of testing than males and females in other groups. This effect was only evident in males that did not experience social disruptions as subadults. Socio-ecological disruptions at postpartum had an unanticipated impact on the hippocampus of the voles. The apical dendrites of the CA3 neurons in male and female voles that experienced either social or ecological disruptions in early life and remained socially isolated as subadults were longer than those in undisturbed voles. Our results suggest that social disruptions experienced in early life modulate the male's stress-related behaviors and may thus influence his monogamous tendencies. Exposure to disruptions may also impact the memory circuits of the brain that monogamous animals use to make mating decisions.

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Effects of foraging demand on maternal behaviour and adult offspring anxiety and stress response in C57BL/6 mice

Cited by 35 publications

References 46 publications

Influence of housing variables on the development of stress-sensitive behaviors in the rat

Influence of housing variables on the development of stress-sensitive behaviors in the rat

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity

Socio-Ecological Disruptions at Critical Periods During Development Alter Stress Responses and Hippocampal Dendritic Morphology of Prairie Voles: Implications for Social Monogamy

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