Effects of food deprivation on caffeine consumption in male and female rats

Heppner, Clyde C.; Kemble, Ernest D.

doi:10.1016/0091-3057(86)90484-3

Cited by 31 publications

(12 citation statements)

References 15 publications

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“…During the maintenance phase, the finding that females had more cocaine infusions than males is consistent with rodent studies indicating that females have higher drug self-administration levels than males with a variety of drug classes, such as stimulants (Lynch 2008; Roth and Carroll 2004; Donny et al 2000; Heppner et al 1986), opioids (Cicero et al 2003; Klein et al 1997; Alexander et al 1978; Hadaway et al 1979), cannabinoids (Fattore et al 2009, 2007) and sedatives (Lancaster and Spiegel 1992). Results are mixed, however, for cocaine maintenance, with a few studies showing no sex-specific effects (Perry et al 2013; Kosten and Zhang 2008; Jackson et al 2006; Cosgrove et al 2002; Roberts et al 1989).…”

Section: Discussionsupporting

confidence: 83%

Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats

2015

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Rationale Consistent sex differences are observed in human drug addiction, with females often exceeding males on drug intake. However, there is still a need for animal models for some aspects of addiction such as acquisition of drug self-administration and the subsequent development of drug-seeking. Objectives The present study examined sex differences in the acquisition of self-administration of two widely used stimulants, cocaine and nicotine. Methods Male and female rats self-administered cocaine (0.4 mg/kg/infusion) or nicotine (0.03 mg/kg/infusion) daily under a fixed-ratio 1 (FR 1) schedule until acquisition criteria were met (maximum of 30 sessions). The self-administration criterion for cocaine was ≥20 infusions in a 2 h session and ≥5 infusions in a 1 h session for nicotine. Sex differences were assessed by examining the percentage of rats that met acquisition criteria, the number of sessions to meet criteria and the number of infusions earned during the maintenance phase. Results A significantly higher percentage of male rats acquired both cocaine and nicotine self-administration than females, and males met acquisition criteria in fewer sessions. However, after criteria were met, females self-administered more cocaine than males during the first 5 days of maintenance. There were no sex differences in nicotine infusions post acquisition. Conclusions Differences in acquisition amongst sexes can reveal factors that are integral to initiation of drug use, an often overlooked phase of drug addiction.

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Section: Discussionsupporting

confidence: 83%

Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats

2015

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“…cocaine self-administration in males relative to females are related to the phase of the estrus cycle or estrogen levels (Roberts et al 1989;Lynch and Carroll 2000a). Caffeine intake is also greater in female rats but only under conditions of food restriction (Heppner et al 1986), a finding that agrees with the sex by feeding condition interaction (Pakarinen et al 1998).…”

Section: Discussionmentioning

confidence: 61%

Acquisition of oral phencyclidine self-administration in rhesus monkeys: effect of sex

et al. 2000

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“…Alternatively, uncontrolled environmental factors may have greater effects on inbred than outbred strains. (12,38,72,90)]. Thus, a puzzling aspect of the present results was that there were only two sex differences in taste preferences (with 100 mM saccharin and 316 mM MSG) out of 1526 comparisons.…”

mentioning

confidence: 45%

Preferences of 14 rat strains for 17 taste compounds

Tordoff

Alarcón

Lawler

2008

Physiology & Behavior

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TORDOFF, M.G., L.K. ALARCON AND M.P. LAWLER. Preferences of 14 rat strains for 17 taste compounds. PHYSIOL BEHAV 00(0) 000-000, 2008.--Two-bottle choice tests were used to assess the taste preferences of 8 male and 8 female rats from 3 outbred strains (SD, LE, WI) and 11 inbred strains (BN, BUF, COP, DA, Dahl-S, F344, FHH, LEW, Noble, PVG, SHR). Each rat received a series of 109 48-h tests with a choice between water and a "taste solution". Four to eight concentrations of the following compounds were tested: NaCl, CaCl 2 , NH 4 Cl, KCl, MgCl 2 , saccharin, sucrose, ethanol, HCl, citric acid, quinine hydrochloride (QHCl), caffeine, denatonium, monosodium glutamate (MSG), Polycose, corn oil, and capsaicin. Strain differences (p<0.001) were observed in preferences for at least one concentration of all compounds tested except denatonium (p = 0.0015). There were also strain differences in the following ancillary measures: fungiform papillae number, water intake, food intake, and body weight. There were sex differences in food intake and body weight but no concerted sex differences in any of the other measures, including preferences for any taste solution. This comprehensive source of information can be used to guide the choice of appropriate rat strains and taste solution concentrations for future genetic studies. Keywordssweet; sour; salty; bitter; umami; calcium; oil; trigeminal; strain survey Rats have been used in many experiments to understand the mechanisms underlying the selection of nutrients and taste compounds. The large majority of these studies have been focused on physiological and behavioral controls of ingestion but rarely on genetic ones. The genetic approach has been spearheaded by work in mice, and has led to several recent important advances, such as the identification of sweet, sour, bitter and umami receptors [reviews (4,10,76)]. One reason for this is that genetic and molecular tools are available for the mouse but not well-developed for the rat, although this is changing [e.g., (2,54,55,62,74)]. Another is that there are few appropriate taste phenotype data available for the rat. Genetic analyses in mice generally begin with the discovery of phenotypic differences among inbred strains but most studies aimed at understanding rat taste preferences have used outbred strains. There are a few comparisons of different rat strain preferences for sodium and ethanol (see below) but very limited data involving other taste compounds.The purpose of this study was to provide comprehensive information about the taste preferences of rats that could be used as the basis for subsequent genetic analyses. To this end, we used Address for all correspondence: Michael G. Tordoff, Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104, Phone: (267)-519-4805, Fax: (267)-519-4738, e-mail: tordoff@monell.org. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscri...

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Effects of food deprivation on caffeine consumption in male and female rats

Cited by 31 publications

References 15 publications

Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats

Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats

Acquisition of oral phencyclidine self-administration in rhesus monkeys: effect of sex

Preferences of 14 rat strains for 17 taste compounds

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