Effects of food-borne cholesterol supplementation on lead-induced neurodevelopmental impairments of rats based on BDNF signaling pathway and cholesterol metabolism

Wang, Susu; Lu, An-Xin; Li, Wan-He; Zhang, Hong; Hu, Chunping; Liu, Junxia; Pan, Hui; Wu, Meiqin; Xu, Xiao; Yan, Chen‐Hua; Gao, Zhiqiang

doi:10.1016/j.ecoenv.2023.115026

Cited by 3 publications

(1 citation statement)

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“…65 The important role of BDNF in glucose homeostasis and cholesterol biosynthesis has been demonstrated. Exogenous cholesterol has been shown to restore the impaired signaling of BDNF-TrkB, 66 and activation of BDNF-TrkB induced genes for cholesterol biosynthesis. 67 MetS is also associated with the development of Alzheimer's disease, which is characterized by high cholesterol levels and low expression of BDNF and TrkB in the brain.…”

Section: Bdnf and Cholesterol Metabolism In The Brainmentioning

confidence: 99%

(Epi)genetic Aspects of Metabolic Syndrome Pathogenesis in Relation to Brain-derived Neurotrophic Factor Expression: A Review

Todosenko,

Yurova,

Khaziakhmatova

et al. 2024

Gene Expr

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A key element in the pathogenesis of metabolic syndrome (MetS) is the reprogramming of hypothalamic cells at the genetic level (in the prenatal phase), which leads to neuroinflammation. We hypothesize that alterations in the structure of hypothalamic neurons mediated by (epi)genetic alterations are directly related to impaired expression/production of neurotrophins and neurotransmitters that control the metabolism of substances in the brain and periphery, including brain-derived neurotrophic factor (BDNF). The aim of this review is to describe the molecular genetic and epigenetic role of BDNF in the development of MetS. Articles entered into the National Library of Medicine Medline database via the PubMed interface were used to create this review. We attempted to include as much literature as possible, including reviews, animal studies, cell culture studies, and clinical trials. Studies on BDNF point to its role in metabolic processes, including glucose, insulin, and cholesterol homeostasis. Evidence-based studies show that multiple genes in close proximity to BDNF are involved in the development of MetS. Studies aimed at analyzing BDNF in metabolic diseases using different biological samples will reveal clear pathophysiological links

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Section: Bdnf and Cholesterol Metabolism In The Brainmentioning

confidence: 99%