Effects of Folpet, Captan, and Captafol on Human Aromatase in JEG-3 Cells

Ge, Heng; Chen, Lanlan; Su, Ying; Jin, Chunyan; Ge, Ren‐Shan

doi:10.1159/000484171

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…Ziram has also been identified as an endocrine disruptor [ 38 ]. Exposure of JEG-3 cells to captan leads to decreased oestradiol production [ 39 ]. Endocrine-disrupting chemicals (EDCs) can alter folliculogenesis, targeting the aromatic hydrocarbon receptor (AhR) or oestrogen receptors (ER) [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice

Dopavogui

Cadoret

Loison

et al. 2022

IJMS

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Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, with endocrine-disrupting properties is considered to be involved in this reproductive disorder, especially when it occurs during early life. Pesticides are present in various facets of the environment, and consumers are exposed to a combination of multiple pesticide residues through food intake. The consequences of such exposure with respect to female fertility are not well known. Therefore, we aimed to assess the impact of pre- and postnatal dietary exposure to a pesticide mixture on folliculogenesis, a crucial process in female reproduction. Mice were exposed to the acceptable daily intake levels of six pesticides in a mixture (boscalid, captan, chlorpyrifos, thiacloprid, thiophanate and ziram) from foetal development until 8 weeks old. Female offspring presented with decreased body weight at weaning, which was maintained at 8 weeks old. This was accompanied by an abnormal ovarian ultrastructure, a drastic decrease in the number of corpora lutea and progesterone levels and an increase in ovary cell proliferation. In conclusion, this study shows that this pesticide mixture that can be commonly found in fruits in Europe, causing endocrine disruption in female mice with pre- and postnatal exposure by disturbing folliculogenesis, mainly in the luteinisation process.

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Section: Discussionmentioning

confidence: 99%

Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice

Dopavogui

Cadoret

Loison

et al. 2022

IJMS

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“…(Amini and Sidovich, 2010;Khare et al, 2016). Abnormal cell division in plants, destruction of useful and non-target soil microorganisms as well as toxicity and disruption of the normal reproductive cycle in humans are some of the harmful effects associated with the use of these chemicals (Dane and Dalgic, 2005;Fawole et al, 2009., Ge et al, 2018. Heat treatment has shown promise in the management of some plant diseases, especially those that are seedborne (Gilbert et al, 2005) and that may be present as contaminants, while biological control has been used successfully to manage certain diseases of crops incited by Fusarium spp.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of heat treatment and bio-priming of cowpea seeds for the management of fusarium wilt disease in the screen house

Ajayi¹,

Evbenata²

2020

J. Agric. Crop Res

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Fusarium wilt is one of the most devastating diseases of cowpea. The pathogen, Fusarium oxysporum f.sp. tracheiphilum is soil and seed-borne. A non-chemical approach was designed for the management of the disease in the present study. Hot water (physical) at three temperatures, 40 50 and 60°C, and Trichoderma viride (biological) at 10 6 spores/ml were evaluated singly and synergistically in the laboratory. The duration of exposure to hot water was 5 min, after which seeds were allowed to cool followed by priming in sterile water (sole hot water treatment) or T. viride (synergistic physical and bio-control) medium in Petri-dishes for 72 h. The control consisted of seed treated with water at ambient temperature, while the standard check was seeds dressed with Mancozeb fungicide. Both were primed in a sterile water medium. Nine treatments were evaluated in all. Germinated seeds were transplanted into plastic pots containing soil infested with F. oxysporum at 10 6 spores/ml in the screen house. The experimental layout was completely randomized design and data collected were subjected to statistical analysis and mean separation. Results showed that seeds treated with 50°C hot water only had the highest germination percentage, 96.66%, and seedling vigour, 460.98. Disease incidence and severity values were least in seeds treated with synergistic hot water at 50°C and priming in T. viride medium. The highest number (77.33) and weight (13.41 g) of seeds were also recorded for the same treatment, while the least, 18 and 3.60 g were obtained from control. Integrated use of hot water (50°C) and bio-priming in T. viride medium can be recommended for use in the management of fusarium wilt disease of cowpea.

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Improved analysis of folpet and captan in foods using liquid chromatography-triple quadrupole linear ion trap mass spectrometry: applying mass filtering, collision, and trapping conditions

et al. 2023

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Effects of Folpet, Captan, and Captafol on Human Aromatase in JEG-3 Cells

Cited by 10 publications

References 9 publications

Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice

Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice

Evaluation of heat treatment and bio-priming of cowpea seeds for the management of fusarium wilt disease in the screen house

Improved analysis of folpet and captan in foods using liquid chromatography-triple quadrupole linear ion trap mass spectrometry: applying mass filtering, collision, and trapping conditions

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