Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials

Asbaghi, Omid; Ashtary‐Larky, Damoon; Bagheri, Reza; Moosavian, Seyedeh Parisa; Nazarian, Behzad; Afrisham, Reza; Kelishadi, Mahnaz Rezaei; Wong, Alexei; Dutheil, Frédéric; Suzuki, Katsuhiko; Naeini, Amirmansour Alavi

doi:10.3390/nu13072327

Cited by 27 publications

(12 citation statements)

References 65 publications

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“…The suppression of NF-kB pathway results in decreased levels of pro-inflammatory cytokine IL-6 [ 71 ]. IL-6 induces CRP gene expression and inhibits the NF-kB/IL-6 pathway which results in decreased CRP [ 72 , 73 ]. Previous studies showed that probiotics or synbiotics might have hypoglycemic properties [ 74 ]; therefore, probiotic or synbiotic supplementation might modulate inflammation and oxidative stress by controlling blood glucose.…”

Section: Discussionmentioning

confidence: 99%

The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: a GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials

et al. 2022

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Purpose Probiotics or synbiotics consumption have been suggested to reduce the risk of cardiovascular disease (CVD) through a decline in inflammation and oxidative stress, however, the results from studies are conflicting. This study filled this knowledge gap by evaluating randomized controlled trials (RCTs) investigating probiotics or synbiotics intake on adipokines, inflammation, and oxidative stress in patients with prediabetes and type-2 diabetes mellitus (T2DM). Methods We systematically did search up to March 2022 in PubMed/Medline, Scopus, ISI Web of Science, and Cochrane library. A random-effect model was applied to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI) for each outcome. Results A total of 32 RCTs were included in the meta-analysis. This intervention led to a significant decrease in levels of C-reactive protein (CRP) (WMD − 0.62 mg/l; 95% CI − 0.80, − 0.44; p < 0.001), tumor necrosis factor-α (TNF-α) (WMD − 0.27 pg/ml; 95% CI − 0.44, − 0.10; p = 0.002) and malondialdehyde (MDA) (WMD − 0.51 µmol/l; 95% CI − 0.73, − 0.30; p < 0.001), and also a significant increase in levels of glutathione (GSH) (WMD 69.80 µmol/l; 95% CI 33.65, 105.95; p < 0.001), total antioxidant capacity (TAC) (WMD 73.59 mmol/l; 95% CI 33.24, 113.95; p < 0.001) and nitric oxide (NO) (WMD 7.49 µmol/l; 95% CI 3.12, 11.86; p = 0.001), without significant alterations in interleukin-6 (IL-6) and adipokines levels. Conclusion A consumption of probiotics or synbiotics could be a useful intervention to improve cardiometabolic outcomes through a reduced inflammation and oxidative stress in patients with prediabetes and T2DM.

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Section: Discussionmentioning

confidence: 99%

The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: a GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials

et al. 2022

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“…Alcohol and meat intake have been positively associated with inflammation [56][57][58][59] , while folate has been negatively associated with inflammation 60 . Similarly, even in large human population studies, associations between breast cancer and a high inflammation diet show contradictory findings.…”

Section: Amn Identifies Inflammation Linking Lifestyle Factors To Bre...mentioning

confidence: 99%

Active molecular network discovery links lifestyle variables to breast cancer in the Long Island Breast Cancer Study Project

Dolios

et al. 2022

Preprint

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Background/Aim: Healthy lifestyle has been associated with decreased risk of developing breast cancer. Using untargeted metabolomics profiling, which provides unbiased information regarding lifestyle choices such as diet and exercise, we aim to identify the molecular mechanisms connecting lifestyle and breast cancer through network analysis. Methods: A total of 100 post-menopausal women, 50 with breast cancer and 50 cancer-free controls were selected from the Long Island Breast Cancer Study Project (LIBCSP). We measured untargeted plasma metabolomics using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Using the ‘enet’ package, we retained highly correlated metabolites representing active molecular network (AMN) clusters for analysis. A typical machine learning workflow (LASSO) was used to examine associations between cancer status and AMN metabolites and covariates such as BMI, age, and reproductive factors. LASSO was then repeated to examine associations between AMN metabolites and 10 lifestyle related variables including smoking, physical activity, alcohol consumption, meat consumption, fruit and vegetables consumption, and supplemental vitamin use. Results were displayed as a network to uncover biological pathways linking lifestyle factors to breast cancer status. Results: After filtering, there were 1797 metabolomics peaks in the plasma samples. Of these, 851 “active” metabolites were retained in 197 correlation AMN clusters. Using LASSO, breast cancer status was associated with 71 “active” metabolites. Several of these metabolites were associated with lifestyle variables including meat consumption, alcohol consumption, and supplemental β-carotene, B12 and folate use. No individual lifestyle factors were significantly associated with breast cancer status using LASSO, suggesting that metabolites may act as biological intermediaries between healthy lifestyle factors and breast cancer. In particular, DiHODE, a metabolite linked with inflammation, was associated with breast cancer status and connected to β-carotene supplement usage through an AMN. Conclusions: We found several plasma metabolites associated with lifestyle factors and breast cancer status. Future studies investigating the mechanistic role of inflammation in linking supplement usage to breast cancer status are warranted.

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“…Chronic inflammation plays a critical role in the pathogenesis and progression of diabetes and insulin resistance 7–9 . Production of inflammatory cytokines by adipose tissue may play a role in low‐grade systemic inflammation 5,10 .…”

Section: Introductionmentioning

confidence: 99%

“…6 Chronic inflammation plays a critical role in the pathogenesis and progression of diabetes and insulin resistance. [7][8][9] Production of inflammatory cytokines by adipose tissue may play a role in lowgrade systemic inflammation. 5,10 It is well documented that excessive adipose tissue can lead to elevations of inflammatory cytokines such as tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and high sensitivity C-reactive protein (hs-CRP) while reducing anti-inflammatory cytokines such as interleukin-10 (IL-10).…”

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confidence: 99%

The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized double‐blind clinical trial

Moghadam

Rashidlamir

Hosseini

et al. 2022

Brit J Clinical Pharma

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Aims Chronic inflammation is one of the major challenges in the management of obesity and type 2 diabetes mellitus (T2DM). Our primary aim was to assess the anti‐inflammatory effects of Saffron (Crocus sativus L.) supplementation and concurrent training in obese men with T2DM. Methods Sixty obese men with T2DM (age = 39 ± 5 years; body mass = 93.9 ± 6 kg) were randomly assigned to four groups; concurrent training + placebo (CT; n = 15), saffron supplementation (S; n = 15), concurrent training + saffron supplementation (CTS; n = 15), or control (CON; n = 15). The participants in the CT group performed concurrent training (resistance + aerobic) three times per week for 12 weeks and received daily one pill of placebo (maltodextrin); the participants in the S group supplemented with one pill of 100 mg of saffron daily, and the participants in the CTS group participated in both saffron and training intervention while CON group continued regular lifestyle (no training and no supplementation). Inflammatory markers, body composition (evaluated by a multi‐frequency bioelectrical impedance device; Jawon X‐Contact 356), and metabolic profile were evaluated before and after interventions. Results All three interventions significantly (P < .05) decreased TNF‐α (CT = −4.22, S = −1.91, CTS = −9.69 pg/mL), hs‐CRP (CT = −0.13, S = −0.1, CTS = −0.32 ng/mL), IL‐6 (CT = −6.84, S = −6.36, CTS = −13.55 pg/mL), IL‐1β (CT = −8.85, S = −6.46, CTS = −19.8 pg/mL), FBG (CT = −6.97, S = −2.45, CTS = −13.86 mg/dL), insulin (CT = −0.13, S = −0.03, CTS = −0.21 mU/L), HOMA‐IR (CT = −0.12, S = −0.04, CTS = −0.21), HbA1c (CT = −0.17, S = −0.11, CTS = −0.26%), and increased IL‐10 (CT = 1.09, S = 0.53, CTS = 2.27 pg/mL) concentrations. There was a positive correlation between changes in BFP with hs‐CRP, IL‐6, IL‐1β and TNF‐α, and IL‐10 concentrations across the intervention groups. Additionally, significant differences were observed between the changes for all variables in the CTS group compared to CT, S and CON groups (P < .05). Conclusion It seems that an interaction of saffron supplementation and concurrent training has more efficient effects on anti‐inflammatory status compared to saffron supplementation or concurrent training alone.

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Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials

Cited by 27 publications

References 65 publications

Active molecular network discovery links lifestyle variables to breast cancer in the Long Island Breast Cancer Study Project

The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized double‐blind clinical trial

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