Abstract:Purpose Supplements are commonly used to prevent cardiovascular diseases. Unfortunately, studies on folic acid supplementation have failed to support its benefit with pre-existing cardiovascular disease. Observational data suggest the benefit may be greater for healthy and at-risk individuals, but clinical trials have yet to be presented. The purpose of this paper is to systematically review evidence regarding the effectiveness of folic acid supplementation on homocysteine levels among healthy people who are a… Show more
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