Effects of Fluticasone Furoate Nasal Spray on Parameters of Eosinophilic Inflammation in Patients With Nasal Polyposis and Perennial Allergic Rhinitis

Mirković, Cveta Špadijer; Perić, Aleksandar; Đurđević, Biserka Vukomanović; Vojvodić, Danilo

doi:10.1177/0003489417713505

Cited by 6 publications

(9 citation statements)

References 34 publications

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“…2a). Eotaxin and RANTES are chemokines-regulating EOS [32,33]. ELISA results showed that OVA induction increased the contents of eotaxin and RANTES in mouse NALF, while miR-181a-5p overexpression treatment reversed these trends (p < 0.01; Fig.…”

Section: Mir-181a-5p Overexpression Protected Against Treg/ Th17 Immu...mentioning

confidence: 82%

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Mechanism of miR-181a-5p in Regulatory T/T-Helper 17 Immune Imbalance and Asthma Development in Mice with Allergic Rhinitis

Chen

et al. 2021

Int Arch Allergy Immunol

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Introduction: Allergic rhinitis (AR) is an immune disorder and also a risk factor of asthma. microRNAs (miRNAs) are implicated in autoimmune diseases, including RA. This study investigated effect of miR-181a-5p on regulatory T (Treg)/ T-helper (Th) 17 immune imbalance in AR. Methods: A murine model of AR was established and treated with lentivirus modified miR-181a-5p. The allergic symptoms of mice were examined. The contents of Th17-related cytokines (interferon [IFN]-γ and interleukin [IL]-6), Treg-related cytokine (IL-10), and Treg-specific nuclear transcription factor (Foxp3) in nasal mucosa and lung tissues were determined. The proportion of Treg and Th17 cells was analyzed by flow cytometry. The level of ovalbumin-specific immunoglobulin E in the serum, and the contents of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid and IFN-γ, IL-6, and IL-10 in nasal lavage fluid were measured. The targeting relationship between miR-181a-5p and high mobility group box chromosomal protein 1 (HMGB1) was verified. HMGB1 and receptor for advanced glycation end products (RAGE) expression in RA were determined, and the interaction between HMGB1 and RAGE was detected. Results: miR-181a-5p expression was reduced in AR mice. miR-181a-5p overexpression attenuated allergic behaviors, alleviated Treg/Th17 imbalance, and delayed asthma development. HMGB1 and RAGE were elevated in AR mice. miR-181a-5p targeted HMGB1, and HMGB1 bound to RAGE, while miR-181a-5p overexpression reduced the binding between them. Activating HMGB1/RAGE reversed the protective effect of miR-181a-5p overexpression on AR and induced the development of asthma. Conclusion: miR-181a-5p overexpression reduced the binding of HMGB1 and RAGE by inhibiting HMGB1, thus alleviating Treg/Th17 immune imbalance and blocking AR from developing into asthma.

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Section: Mir-181a-5p Overexpression Protected Against Treg/ Th17 Immu...mentioning

confidence: 82%

“…EOS is a kind of granulated innate immune cells, and eosinophilic inflammation is typically related to the aggravation of asthma [51]. RANTES and eotaxin are critical chemoattractants for EOS [32,33]. OVA induction increased the contents of eotaxin and RANTES in NALF, while miR-181a-5p overexpression decreased their contents.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of miR-181a-5p in Regulatory T/T-Helper 17 Immune Imbalance and Asthma Development in Mice with Allergic Rhinitis

Chen

et al. 2021

Int Arch Allergy Immunol

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“…A first generation corticosteroid, dexamethasone, is no longer preferred due to its side effects ( 452 ). The second generation corticosteroids, including beclomethasone dipropionate (aerosol) ( 453 - 460 ), budesonide (aqueous) ( 461 - 463 ), ciclesonide (aqueous or aerosol) ( 464 - 466 ), flunisolide (aqueous), fluticasone furoate (aqueous) ( 467 - 470 ), fluticasone propionate (aqueous) ( 471 - 474 ), triamcinolone acetonide (aqueous) ( 475 - 476 ) and mometasone furotate (aqueous) ( 466 , 477 - 482 ) have been used in nasal spray preparations until today.…”

Section: Treatment Of Allergic Rhinitismentioning

confidence: 99%

Turkish Guidelines for Diagnosis and Treatment of Allergic Rhinitis (ART)

Ecevit¹,

Özcan²,

Can³

et al. 2021

TAO

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Object: To prepare a national guideline for Otorhinolaryngologist who treat allergic rhinitis patients. Methods: The study was conducted by three authors, namely the writing support team. The support team made the study plan, determined the writing instructions, chose the subgroups including the advisory committee, the advisors for authors and the authors. A workshop was organized at the very beginning to explain the details of the study to the team. Advisors took the chance to meet their coworkers in their subgroups and determined the main headings and subheadings of the guideline, together with the authors. After key words were determined by the authors, literature search was done in various databases. The authors keep in touch with the advisors and the advisors with the advisory committee and the support group at every stage of the study. National and International published articles as well as the abstracts of unpublished studies, imperatively presented in National Congresses, were included in this guideline. Only Guideline and meta-analyses published in last seven years (2013-2017) and randomized controlled studies published in last two years (2015-2017) were included. After all work was completed by the subgroups, support team brought all work together and edited the article. Results: A detailed guideline about all aspects of allergic rhinitis was created. Conclusion: The authors believe that this guideline will enable a compact and up-to-date information on allergic rhinitis to healthcare professionals. This guideline is the first in the field of Otolaryngology in Turkey. It should be updated at regular intervals.

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“…181 Existing evidence indicates an inhibitory effect of Levalbuterol on airway smooth muscle cell proliferation and cell growth, possibly by activating the cAMP/PKA pathway and inhibiting phosphoinositide 3-kinase (PI-3 kinase), NF-kB and retinoblastoma (Rb) protein expression. 182 Despite increasing the dose of inhaled corticosteroids, the addition of long-acting β-agonist salmeterol offers a better therapeutic response in asthmatic control. 212 Bronchodilators such as β-agonist and anticholinergic agents have been a good choice in patients with asthma and chronic obstructive pulmonary disease (COPD); however, the administration of β-agonist has been associated with side effects including the risk of cardiovascular complicacy, arrhythmias, hypoxemia, tachycardia, palpitations, and inflammatory response.…”

Section: Eosinophils In Modulating Epithelial Injurymentioning

confidence: 99%

Eosinophil: A central player in modulating pathological complexity in asthma

Pritam¹,

Manna²,

Sahu

et al. 2021

aei

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Eosinophils are the major inflammatory cells which play a crucial role in the development of allergic and non-allergic asthma phenotypes. Eosinophilic asthma is the most heterogeneous phenotype where activated eosinophils are reported to be significantly associated with asthma severity. Activated eosinophils display an array of cell adhesion molecules that not only act as an activation marker, suitable for assessing severity, but also secrete several tissue factors, cytokines and chemokines which modulate the clinical severity. Eosinophil activations are also strictly associated with activation of other hetero cellular populations like neutrophils, macrophages, mast cells, and platelets which culminate in the onset and progression of abnormal phenotypes such as bronchoconstriction, allergic response, fibrosis instigated by tissue inflammation, epithelial injury, and oxidative stress. During the activated state, eosinophils release several potent toxic signaling molecules such as major basic proteins, eosinophil peroxidase, eosinophil cationic protein (ECP), and lipid mediators, rendering tissue damage and subsequently leading to allergic manifestation. The tissue mediators render a more complex manifestation of a severe phenotype by activating prominent signaling cross-talk. Here, in the current review with the help of search engines of PubMed, Medline, etc, we have tried to shed light and explore some of the potent determinants regulating eosinophil activation leading to asthma phenotype.

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Effects of Fluticasone Furoate Nasal Spray on Parameters of Eosinophilic Inflammation in Patients With Nasal Polyposis and Perennial Allergic Rhinitis

Abstract: The levels of RANTES and eotaxin-2 in nasal fluid could be reliable markers for assessing corticosteroid administration outcomes.

Cited by 6 publications

References 34 publications

Mechanism of miR-181a-5p in Regulatory T/T-Helper 17 Immune Imbalance and Asthma Development in Mice with Allergic Rhinitis

Mechanism of miR-181a-5p in Regulatory T/T-Helper 17 Immune Imbalance and Asthma Development in Mice with Allergic Rhinitis

Turkish Guidelines for Diagnosis and Treatment of Allergic Rhinitis (ART)

Eosinophil: A central player in modulating pathological complexity in asthma

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