Effects of Fluoride-Supplemented Sucrose on Experimental Dental Caries and Dental Plaque PH

Cutress, T.W.; Sissons, C.H.; Pearce, E.I.F.; Wong, L.; Anderssén, Karin; Angmar‐Månsson, Birgit

doi:10.1177/08959374950090010101

“…It is these latter e¡ects that seem to be most pertinent to the antimicrobial^anticaries properties of £uoride. Fluoride can even have an anticaries e¡ect when added to sucrose in the diet [28,84] and can act in concert with other anticaries agents [40,41,121]. Moreover, £uoride appears to have important ecological e¡ects on dental plaque in that it acts to reduce acidi¢cation and in the long run serves to select for a less acid-tolerant, less cariogenic microbiota, as suggested by, for example, Marsh [75].…”

Section: Weak Acids and Dental Cariesmentioning

confidence: 99%

Fluoride and organic weak acids as modulators of microbial physiology

Marquis¹

2003

FEMS Microbiology Reviews

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Fluoride is widely used as an anticaries agent in drinking water and a variety of other vehicles. This use has resulted in major health benefits. However, there are still open questions regarding the mechanisms of anticaries action and the importance of antimicrobial effects in caries reduction. Fluoride acts in multiple ways to affect the metabolism of cariogenic and other bacteria in the mouth. F(-)/HF can bind directly to many enzymes, for example, heme-containing enzymes or other metalloenzymes, to modulate metabolism. Fluoride is able also to form complexes with metals such as aluminum or beryllium, and the complexes, notably AlF(4)(-) and BeF(3)(-).H(2)O, can mimic phosphate with either positive or negative effects on a variety of enzymes and regulatory phosphatases. The fluoride action that appears to be most important for glycolytic inhibition at low pH in dental plaque bacteria derives from its weak-acid properties (pK(a)=3.15) and the capacity of HF to act as a transmembrane proton conductor. Since many of the actions of fluoride are related to its weak-acid character, it is reasonable to compare fluoride action to those of organic weak acids, including metabolic acids, food preservatives, non-steroidal anti-inflammatory agents and fatty acids, all of which act to de-energize the cell membrane by discharging DeltapH. Moreover, with the realization that the biofilm state is the common lifestyle for most microorganisms in nature, there is need to consider interactions of fluoride and organic weak acids with biofilm communities. Hopefully, this review will stimulate interest in the antimicrobial effects of fluoride or other weak acids and lead to more effective use of the agents for disease control and other applications.

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“…It is these latter effects that seem to be most pertinent to the antimicrobial–anticaries properties of fluoride. Fluoride can even have an anticaries effect when added to sucrose in the diet [28,84] and can act in concert with other anticaries agents [40,41,121]. Moreover, fluoride appears to have important ecological effects on dental plaque in that it acts to reduce acidification and in the long run serves to select for a less acid‐tolerant, less cariogenic microbiota, as suggested by, for example, Marsh [75].…”

Section: Weak Acids and Dental Cariesmentioning

confidence: 99%

Fluoride and organic weak acids as modulators of microbial physiology

Marquis

¹

,

Clock

²

,

Mota‐Meira

³

2003

View full text Add to dashboard Cite

Fluoride is widely used as an anticaries agent in drinking water and a variety of other vehicles. This use has resulted in major health benefits. However, there are still open questions regarding the mechanisms of anticaries action and the importance of antimicrobial effects in caries reduction. Fluoride acts in multiple ways to affect the metabolism of cariogenic and other bacteria in the mouth. F(-)/HF can bind directly to many enzymes, for example, heme-containing enzymes or other metalloenzymes, to modulate metabolism. Fluoride is able also to form complexes with metals such as aluminum or beryllium, and the complexes, notably AlF(4)(-) and BeF(3)(-).H(2)O, can mimic phosphate with either positive or negative effects on a variety of enzymes and regulatory phosphatases. The fluoride action that appears to be most important for glycolytic inhibition at low pH in dental plaque bacteria derives from its weak-acid properties (pK(a)=3.15) and the capacity of HF to act as a transmembrane proton conductor. Since many of the actions of fluoride are related to its weak-acid character, it is reasonable to compare fluoride action to those of organic weak acids, including metabolic acids, food preservatives, non-steroidal anti-inflammatory agents and fatty acids, all of which act to de-energize the cell membrane by discharging DeltapH. Moreover, with the realization that the biofilm state is the common lifestyle for most microorganisms in nature, there is need to consider interactions of fluoride and organic weak acids with biofilm communities. Hopefully, this review will stimulate interest in the antimicrobial effects of fluoride or other weak acids and lead to more effective use of the agents for disease control and other applications.

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“…The above explanation could partly be validated if no deposition of fluoride in plaque had occurred. This was not tested in the study but has been demonstrated in a similar experimental design by Cutress et al (1995). The fact that the blocks were exposed to sugar and fluoride extraorally means that the plaque-enamel complex was not exposed to the salivary flow which would have been stimulated by the sucrose content.…”

Section: Discussionmentioning

confidence: 84%

Effects on Demineralization of Enamel by Fluoridated Sucrose: A Pilot Study in an in Situ Caries Model

Carlsson

¹

,

Angmar‐Månsson

²

,

Redmo-Emanuelsson

³

et al. 1995

Adv Dent Res.

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1

0

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Blocks of human enamel, placed in removable partial dentures, were allowed to acquire natural plaque for seven days and were exposed extra-orally to a cariogenic challenge by repeated periods in a fluoride-sucrose solution. As a control, enamel blocks were exposed extra-orally to a sucrose solution. After two weeks of cariogenic challenge, the blocks were examined for mineral loss by quantitative microradiography on thin sections of the enamel. The results from six subjects showed that no significant effect on demineralization could be detected by the addition of fluoride corresponding to fluoride/sugar content of 1 mg/kg, 5 mg/kg, or 10 mg/kg (dry weight). One subject did not develop lesions at all, either with fluoride-sucrose or with sucrose exposure alone.

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Effects of Fluoride-Supplemented Sucrose on Experimental Dental Caries and Dental Plaque PH

Cited by 12 publications

References 30 publications

Fluoride and organic weak acids as modulators of microbial physiology

Fluoride and organic weak acids as modulators of microbial physiology

Fluoride and organic weak acids as modulators of microbial physiology

Effects on Demineralization of Enamel by Fluoridated Sucrose: A Pilot Study in an in Situ Caries Model

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