Effects of fluoride on bone in Finland: Histomorphometry of cadaver bone from low and high fluoride areas

Arnala, I; Alhava, Esko; Kauranen, P.

doi:10.3109/17453678508994346

Cited by 29 publications

(10 citation statements)

References 13 publications

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“…Sr and F are mainly stored in bones and the heavier skeleton weight of the males (Warren and Maples, 1997) could explain the lower F and Sr values. Such differences (for F) have already been observed in a modern population (Arnala et al, 1985). Furthermore, pregnancy and breastfeeding can cause ORSr variations (Kostial et al, 1969;Blanusa et al, 1970;Blakely, 1989).…”

Section: Variations Within the Chupicuaro Populationmentioning

confidence: 88%

Intra-skeletal variability in trace elemental content of Precolumbian Chupicuaro human bones: the record of post-mortem alteration and a tool for palaeodietary reconstruction

Maurer

Gérard

Person

et al. 2011

Journal of Archaeological Science

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Section: Variations Within the Chupicuaro Populationmentioning

confidence: 88%

Intra-skeletal variability in trace elemental content of Precolumbian Chupicuaro human bones: the record of post-mortem alteration and a tool for palaeodietary reconstruction

Maurer

Gérard

Person

et al. 2011

Journal of Archaeological Science

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“…A study performed in Finland in 1985 found that bone F concentrations were typically 3-fold higher in adult subjects (mean age 60 yrs) who had resided in a fluoridated community for 20 years compared with subjects from nonfluoridated areas [ 187 ]. In men, the highest concentration was 2750 ppm.…”

Section: Discussionmentioning

confidence: 99%

“…In men, the highest concentration was 2750 ppm. In women, the highest concentration of F in bone was found in a subject with impaired renal function (3890 ppm) [ 187 ]. However, it is important to note that tea consumption is uncommon in Finland and the subjects had not ingested fluoridated water throughout their lifetime.…”

Section: Discussionmentioning

confidence: 99%

Black Tea Source, Production, and Consumption: Assessment of Health Risks of Fluoride Intake in New Zealand

Waugh¹,

Godfrey

Limeback

et al. 2017

Journal of Environmental and Public Health

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In countries with fluoridation of public water, it is imperative to determine other dietary sources of fluoride intake to reduce the public health risk of chronic exposure. New Zealand has one of the highest per capita consumption rates of black tea internationally and is one of the few countries to artificially fluoridate public water; yet no information is available to consumers on the fluoride levels in tea products. In this study, we determined the contribution of black tea as a source of dietary fluoride intake by measuring the fluoride content in 18 brands of commercially available products in New Zealand. Fluoride concentrations were measured by potentiometric method with a fluoride ion-selective electrode and the contribution of black tea to Adequate Intake (AI) and Tolerable Upper Intake Level (UL) was calculated for a range of consumption scenarios. We examined factors that influence the fluoride content in manufactured tea and tea infusions, as well as temporal changes in fluoride exposure from black tea. We review the international evidence regarding chronic fluoride intake and its association with chronic pain, arthritic disease, and musculoskeletal disorders and provide insights into possible association between fluoride intake and the high prevalence of these disorders in New Zealand.

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“…[25][26][27] In another study which investigated BMD after excessive fluoride intake in Isparta city, Yildiz et al 19 showed that excessive fluoride intake via drinking water causes increased BMD values compared with normal patients. The mandibular BMD was also found to be higher in the fluorosis group which was similar to the results from a study conducted on femurs.…”

Section: Discussionmentioning

confidence: 99%

“…23 It is generally accepted that there is a relationship between alveolar bone loss in edentulous patients and metabolic bone disease. 4,5,[23][24][25]45 Fluoride becomes incorporated into bone mineral either by fixing to the surface of the hydroxyapatite crystal or by exchanging with the hydroxyl ion on the surface or inside the crystal. 12 Gupta et al 24 showed that high fluoride intake affects the results of skeletal scintigraphy, including the calvaria and mandible, which both show increases in active bone formation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mandibular bone mineral density using the dual-energy X-ray absorptiometry technique in edentulous subjects living in an endemic fluorosis region

Büyükkaplan

Guldag²

2012

Dentomaxillofacial Radiology

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Objectives: Fluoride is one of the biological trace elements with a strong affinity for osseous, cartilaginous and dental tissue. The dental and skeletal effects of high fluoride intake have already been studied in the literature, but little is known about the effects of high fluoride intake on edentulous mandibles. The purpose of this study was to evaluate the effects of high fluoride intake on mandibular bone mineral density (BMD) measured by the dualenergy X-ray absorptiometry (DXA) technique in edentulous individuals with systemic fluorosis. Methods: 32 people who were living in an endemic fluorosis area since birth and 31 people who were living in a non-endemic fluorosis area since birth (control group) participated in this study. Systemic fluorosis was diagnosed in the patients using the sialic acid (NANA)/ glycosaminoglycan (GAG) ratio. The BMDs of the mandibles were determined by the DXA technique. Results: The serum NANA/GAG ratios in the fluorosis group were significantly lower than those in the control group (p , 0.001). There was also a statistically significant difference in mandibular BMD measurements (p , 0.05) between the systemic fluorosis and control groups, as measured by the DXA technique. Mandibular body BMD measurements were higher in the fluorosis group (1.25¡0.24 g cm 22 ) than in the control group (1.01¡0.31 g cm 22 ). Conclusions:The results of the study showed that fluoride intake higher than the optimum level causes increased mandibular BMD in edentulous individuals. Further dose-related studies are needed to determine the effects of high fluoride intake on bony structures of the stomatognathic system.

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Effects of fluoride on bone in Finland: Histomorphometry of cadaver bone from low and high fluoride areas

Cited by 29 publications

References 13 publications

Intra-skeletal variability in trace elemental content of Precolumbian Chupicuaro human bones: the record of post-mortem alteration and a tool for palaeodietary reconstruction

Intra-skeletal variability in trace elemental content of Precolumbian Chupicuaro human bones: the record of post-mortem alteration and a tool for palaeodietary reconstruction

Black Tea Source, Production, and Consumption: Assessment of Health Risks of Fluoride Intake in New Zealand

Evaluation of mandibular bone mineral density using the dual-energy X-ray absorptiometry technique in edentulous subjects living in an endemic fluorosis region

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