Effects of fluoride and aluminum on expressions of StAR and P450scc of related steroidogenesis in guinea pigs' testis

Dong, Chunguang; Cao, Jianhua; Cao, Chunfang; Han, Yichao; Wu, Shouyan; Wang, Shaolin; Wang, Jundong

doi:10.1016/j.chemosphere.2015.12.064

Cited by 32 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epidemiological studies indicated that environmental exposure to fluoride was associated with male infertility and low birth rates in endemic areas of fluorosis (Long et al 2009;Ortiz-Perez et al 2003). Furthermore, numerous clinical investigations and animal studies revealed that fluoride is a testicular toxicant that disrupts reproductive hormones levels, induces structural and functional defects in sperm and consequently reduced fertility (Long et al 2009;Lu et al 2014;Sun et al 2014;Dong et al 2016). Indeed, the three important processes namely the spermatogenesis, capacitation and acrosome reaction which spermatogonia undergoes to finally fertilize an oocyte have been reported to be impaired by excessive exposure to fluoride (Long et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain–pituitary–gonadal axis in male rats

Adedara

Olabiyi

Ojuade

et al. 2017

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain–pituitary–gonadal axis in male rats

Adedara

Olabiyi

Ojuade

et al. 2017

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

“…Studies have shown that excessive F consumption can take adverse effects on semen quality and damage the normal structure of testis [17,18]. In our study, the use of different genotype animal models of uorosis revealed that excessive NaF intake in the testes of WT mice could induce sperm count reduction and increase the rate of abnormal spermatozoa.…”

Section: Discussionmentioning

confidence: 54%

IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis

Zhao

Wang

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Backgroud Reproductive toxicity of fluoride (F) has been verified by epidemiological and experimental investigations. Based on the literature and our recent studies, as well as the reports inferred by sequencing analysis of mice with normal and fluorosis testes, it is suggested that the interleukin 17A (IL-17A) signaling pathway may be the key link of the damage in testes of the fluorosis animals. To investigate the role of IL-17A in the process of F-induced testicular injury, we exposed wild type (WT) genotype mice and IL-17A knockout (IL-17A-/-) genotype mice to 50mg/L Sodium fluoride (NaF) at 90 days, respectively.Results From the results, we verified IL-17A played a key role in the exacerbation of testicular injuries in fluoride-exposed animals, and found IL-17A knockdown could evidently ameliorate the lesion of testicular damage, including the improves in semen quality,maintain testicular morphology and reducing the immune response in testis. In addition, our results showed that Leydig cells exposed to NaF and recombinant IL-17A in vitro displayed both abnormal apoptoses and decreased secretions of testosterone.Conclusions Altogether, our findings proved that IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis. This study also provides the mechanism of reproductive toxicity of F, the basis for scientific diagnosis, and possible target drug design.

show abstract

“…Dong et al [20] also reported decreased concentration of serum testosterone in guinea pigs. The decline in level of testosterone was 23.67% compared with control group.…”

Section: Discussionmentioning

confidence: 92%

Efficacy of Boerhaavia Diffusa L. On Disruption of Gonadotropins and Testosterone in Fluoride Intoxicated Male Rats

Aggarwal

Khan

2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The present study explored the influence of fluoride exposure on gonadotropins and reproductive hormones.Methods: Male Wistar albino rats weighing 100-150 g were administered with 100, 200, and 300 ppm/kg body weight of sodium fluoride daily for 20 and 40 days. The control group was given 1 ml deionized water/kgbw/day for the same period. At the end of the experimental period, half of the animals were sacrificed and blood serum was collected and testis sample was taken concurrently. Remaining half rats were administrated with two doses (250 mg and 500 mg/kg body weight) of leaf extract of Boerhaavia diffusa L. for another 20 days. Serum level of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and intratesticular level of testosterone were evaluated.Results: It was found that fluoride intoxication resulted in significant increase in the level of FSH (p<0.01) and LH (p<0.0001) while significant decrease in the serum (p<0.01) and testis (p<0.0001) level of testosterone. A significant (p<0.0001) positive correlation was found between level of serum fluoride and gonadotropins: FSH (20 days, r=0.708 and 40 days, r=0.795) and LH (20 days, r=0.779 and 40 days, r=0.891). However, there was significant (p<0.0001) negative correlation existed between serum fluoride and testosterone levels in serum (20 days, r=−0.780 and 40 days, r=−0.862) as well as testis (20 days, r=−0.915 and 40 days, r=−0.938). Conclusion:It was found that administration of B. diffusa L. alleviated the adverse effects of fluoride on reproductive endocrine functions.

show abstract

Effects of fluoride and aluminum on expressions of StAR and P450scc of related steroidogenesis in guinea pigs' testis

Cited by 32 publications

References 26 publications

Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain–pituitary–gonadal axis in male rats

Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain–pituitary–gonadal axis in male rats

IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis

Efficacy of Boerhaavia Diffusa L. On Disruption of Gonadotropins and Testosterone in Fluoride Intoxicated Male Rats

Contact Info

Product

Resources

About