Effects of Fluid Volume Changes during Hemodialysis on the Biophysical Parameters of the Skin

Brazzelli, Valeria; Borroni, G.; Vignoli, G. P.; Rabbiosi, G.; Cavagnino, A; Berardesca, Enzo

doi:10.1159/000247113

Cited by 15 publications

(10 citation statements)

References 3 publications

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“…Brazzelli et al [7] noticed that acute fluid removal after a single HD session reduced skin thickness and elasticity at volar forearm. In this study, we found that skin water content both at forearm and leg was increased after a single HD session ( fig.…”

Section: Discussionmentioning

confidence: 99%

Pruritus and Hydration State of Stratum corneum in Hemodialysis Patients

et al. 2000

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Background: Xerosis is the most frequent cutaneous manifestation in hemodialysis (HD) patients, but the association between dry skin and pruritus remains to be clarified. Since the skin surface hygrometer can detect the changes of water content in the stratum corneum more sensitively, we re-examined the relationship between the severity of pruritus and water content in dialysis patients. Methods: Fifty patients who had been undergoing regular HD were examined for the degree of pruritus by clinical grading. Water contents in the stratum corneum at volar forearm and lower leg were assessed by measurement of high-frequency conductance using a skin surface hygrometer both at pre- and postdialysis. Results: Thirty-seven (74%) of dialysis patients complained of pruritus. High-frequency conductance values were significantly lower in HD patients compared to those of age-matched control subjects (n = 13) both at forearm (35.1 ± 3.0 vs. 73.3 ± 10.4 µS, p < 0.01) and lower leg (14.2 ± 1.1 vs. 52.4 ± 7.5 µS, p < 0.01). There was no relationship between the severity of pruritus and age, gender, HD duration, underlying renal disease, or removing fluid volume. A significant reduction of itching score was found in patients using polysulfone membrane. A single HD session using cellulose triacetate or polysulfone membrane significantly increased water content both at forearm and lower leg (p < 0.05). However, the degree of pruritus did not correlate with the skin water content both at the beginning and the end of HD session, respectively. Conclusion: It follows from these findings that water content in the stratum corneum was reduced in HD patients, but did not correlate with the severity of pruritus.

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Section: Discussionmentioning

confidence: 99%

Pruritus and Hydration State of Stratum corneum in Hemodialysis Patients

et al. 2000

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“…T HE OVERALL mechanical properties of human skin depend mainly on the nature and organisation of the dermal collagen and elastic fiber network, water, proteins and macromolecules embedded in the extracellular matrices (1), with some contribution by the epidermis and the stratum corneum (2)(3). The investigation of the mechanical properties of healthy and diseased skin allows both quantitative and qualitative assessment of certain dermal alterations (4)(5)(6)(7)(8), enabling evaluation of treatment efficacy (9)(10)(11)(12)(13). The efficacy of cosmetic products in terms of emolliency (2,14) and hydration (15), and the effects of skin ageing can also be observed by the study of the mechanical properties of skin (1,9,(16)(17)(18)(19)(20)(21)(22).…”

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confidence: 99%

In vivo model of the mechanical properties of the human skin under suction

Diridollou

Patat²,

Gens

et al. 2000

Skin Research and Technology

296

225

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BACKGROUND/AIMS: A new method for the in vivo characterization of the mechanical properties of skin has been developed. This comprises a suction chamber and an ultrasound device to measure both the vertical displacement of the skin's surface, and the skin's thickness. METHODS: A mathematical model of the mechanical behaviour of a taught elastic membrane is used to obtain a set of parameters intrinsic to the skin, such as Young's modulus (E) and the initial stress (sigma0), which reflect the stiffness and the natural tension of the skin, respectively. We also calculated an index of non-elasticity of the skin (unrestored energy ratio, UER), which takes into account the volume of tissue mobilized. It determines a ratio between the energy input to the skin and the energy it dissipates. These parameters were evaluated from the volar forearm of 10 normal male volunteers. RESULTS: The results were: 129+/-88 kPa for E, 13.5+/-5 kPa for sigma0, and 0.42+/-0.04 for UER; with reproducibilities of 9.5%, 12.4% and 6.4%, respectively. CONCLUSIONS: This new suction device was found useful for the study of the behaviour of the skin, and the device may be used for the evaluation of certain skin diseases and their therapy.

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“…It is well‐known that increased fluid intake increases the water content in the dermis because the water accumulates in this layer . An increased water content in the dermis may also increase the water content in the epidermis . A higher epidermal water content may change the water concentration gradient between the SG and the outer SC cells.…”

Section: Discussionmentioning

confidence: 99%

“…32 An increased water content in the dermis may also increase the water content in the epidermis. 33 A higher epidermal water content may change the water concentration gradient between the SG and the outer SC cells. On the other hand such a simplified view may be wrong because the water content of the SC is largely determined by the natural moisturizing factors, the structure of the corneocytes and the SC intercellular lipids.…”

Section: Discussionmentioning

confidence: 99%