Effects of fluid ingestion on cognitive function after heat stress or exercise-induced dehydration

Cian, Corinne; Barraud, Pierre Alain; Melin, B.; Raphel, Christian

doi:10.1016/s0167-8760(01)00142-8

Cited by 361 publications

(315 citation statements)

References 6 publications

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“…In a later study, Cian et al (2000) also demonstrated impairment in short-and longterm memory, visuospatial function, perceptive discrimination and reaction time in dehydrated subjects. The subjects studied also demonstrated increased subjective perception of fatigue following prolonged dehydration, validating the clinical association of hydration status with quality of life (Cian et al, 2001). …”

Section: Pathophysiologysupporting

confidence: 58%

Impaired cognitive function and mental performance in mild dehydration

2003

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Dehydration is a reliable predictor of impaired cognitive status. Objective data, using tests of cortical function, support the deterioration of mental performance in mildly dehydrated younger adults. Dehydration frequently results in delirium as a manifestation of cognitive dysfunction. Although, the occurrence of delirium suggests transient acute global cerebral dysfunction, cognitive impairment may not be completely reversible. Animal studies have identified neuronal mitochondrial damage and glutamate hypertransmission in dehydrated rats. Additional studies have identified an increase in cerebral nicotinamide adenine dinucleotide phosphate-diaphorase activity (nitric oxide synthase, NOS) with dehydration. Available evidence also implicates NOS as a neurotransmitter in long-term potentiation, rendering this a critical enzyme in facilitating learning and memory. With ageing, a reduction of NOS activity has been identified in the cortex and striatum of rats. The reduction of NOs synthase activity that occurs with ageing may blunt the rise that occurs with dehydration, and possibly interfere with memory processing and cognitive function. Dehydration has been shown to be a reliable predictor of increasing frailty, deteriorating mental performance and poor quality of life. Intervention models directed toward improving outcomes in dehydration must incorporate strategies to enhance prompt recognition of cognitive dysfunction.

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Section: Pathophysiologysupporting

confidence: 58%

Impaired cognitive function and mental performance in mild dehydration

2003

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“…Increased cognitive processing time has been linked to dehydration (18,19). The nonsignificant relationship between the urinary hydration markers and cognitive performance in this study may have been due to the choice of the test for determining changes in cognitive function.…”

Section: Original Researchmentioning

confidence: 69%

Hydration status and water turnover of dogsled drivers during an endurance sled dog even in the Arctic

Cox

Ruby

Banse

et al. 2006

International Journal of Circumpolar Health

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Objectives. To determine changes in common urinary markers of hydration maintained by the drivers (mushers) during a wilderness endurance event in the arctic and to determine water turnover in this select group of individuals. Study Design. During this descriptive study, data was systematically collected on hydration, water turnover, changes in resting and exercise heart rate, fatigue and rating of perceived exertion during an arduous dogsled race in the arctic. Methods. Sixteen mushers were recruited for the study, 13 of whom completed the entire race. At five different checkpoints along the 1049-mile trail (symbolic distance), urine was collected. Urine osmolality (U osm ) was determined using freezing point depression. Urine specific gravity (U sg ) was determined using a hand-held refractometer. Water turnover was measured in 5 mushers from rates of deuterium ( 2 H 2 O) elimination (rH 2 O). Prior to the start of the race, and at five checkpoints along the trail, a resting heart rate, fatigue rating scale and a rating of perceived exertion (RPE), were collected. Results. Out of the 13 subjects that completed the event, four of the mushers had a U sg ≥ 1.030 (mean 1.023 ± 0.007) at some point during the event. Ten had a urine osmolality ≥ 900 mOsm L -1 at some point during the event, with an average U osm of 868 ± 277 mOsm L -1 over the duration of the event. Water turnover demonstrated that rH 2 O averaged 2.85 ± 1.18 ml kg -1 day -1 (range 2.03 -4.60) over the duration of the event. Resting heart rate increased significantly over the course of the race. The RPE was related to the overall fatigue rating scale.Conclusions. These data demonstrate that the majority of mushers studied showed signs of dehydration based on common urinary markers during the long-distance dogsled race. The dehydration appears to have had an influence on the resting heart rate, overall fatigue and the rating of perceived exertion during the race. (Int J Circumpolar Health 2006;65(1):45-54.)

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“…Finally, hypohydration has been shown to impair cognitive functions such as alertness, short-term memory, concentration, arithmetic efficiency, psychomotor processing and attention and increase headaches and tiredness (Cian et al 2000;Cian et al 2001;Neave et al 2001;Shirreffs et al 2004;Suhr et al 2004;Ritz and Berrut 2005). The Cr/Gly hyperhydrating protocol developed by Easton et al (2007) has been successfully applied to counter orthostatic intolerance in male subjects undertaking a postural tilt test whereby subjects lay supine for 30 minutes before being tilted head-up to 70º for a further 30 minutes or until the limit of tolerance (Easton et al 2009).…”

Section: Cr Supplementation and Cognitive Enhancement -Effects On Slementioning

confidence: 99%

The effects of creatine supplementation on thermoregulation and physical (cognitive) performance: a review and future prospects

et al. 2016

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Creatine (Cr) is produced endogenously in the liver or obtained exogenously from foods such as meat and fish.In the human body, 95% of Cr is located in the cytoplasm of skeletal muscle either in a phosphorylated (PCr) or free form (Cr). PCr is essential for the immediate rephosphorylation of adenosine di-phosphate (ADP) to adenosine tri-phosphate (ATP). PCr is rapidly degraded at the onset of maximal exercise at a rate that results in muscle PCr reservoirs being substantially depleted. A well-established strategy followed to increase muscle total Cr content is to increase exogenous intake by supplementation with chemically pure synthetic Cr.

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Effects of fluid ingestion on cognitive function after heat stress or exercise-induced dehydration

Cited by 361 publications

References 6 publications

Impaired cognitive function and mental performance in mild dehydration

Impaired cognitive function and mental performance in mild dehydration

Hydration status and water turnover of dogsled drivers during an endurance sled dog even in the Arctic

The effects of creatine supplementation on thermoregulation and physical (cognitive) performance: a review and future prospects

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