Effects of flow pattern, device and formulation on particle size distribution of nebulized aerosol

Hu, Junhua; Zhang, Rui; Beng, Huimin; Deng, Liangjun; Ke, Qingjin; Tan, Wen

doi:10.1016/j.ijpharm.2019.01.025

Cited by 14 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the case of nebulization products, the combination consists of the nebulizer and the drug formulation. Both components account for efficacy by determining the availability (disposition) of the active substance [6,7,8,9,10,11]. The major barriers created by this combination derive from the fact that the manufacturers belong to different industrial sectors, i.e., the mechanical and the pharmaceutical industry [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects

et al. 2019

View full text Add to dashboard Cite

In this work, 13 jet nebulizers, some of which in different configurations, were investigated in order to identify the biopharmaceutical constraints related to the quality attributes of the medicinal products, which affect their safety, efficiency, compliance, and effectiveness. The aerosolization parameters, including the aerosol output, aerosol output rate, mass median aerodynamic diameter, and fine particle fraction, were determined according to the European Standard EN 13544-1, using sodium fluoride as a reference formulation. A comparison between the aerosol output nebulization time and the fine particle fraction displayed a correlation between the aerosol quality and the nebulization rate. Indeed, the quality of the nebulization significantly increased when the rate of aerosol emission was reduced. Moreover, the performance of the nebulizers was analyzed in terms of respirable delivered dose and respirable dose delivery rate, which characterize nebulization as the rate and amount of respirable product that could be deposited into the lungs. Depending on which of these two latter parameters was used, the nebulizers showed different performances. The differences, in terms of the rate and amount of delivered aerosol, could provide relevant information for the appropriate choice of nebulizer as a function of drug product, therapy, and patient characteristics.

show abstract

Section: Introductionmentioning

confidence: 99%

Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Secondly, since we believe that the dead volume of the nebulization cup has a great impact; different models or brands of nebulization devices with different dead volumes or different properties may produce different results in terms of aerosol parameters. Several studies have demonstrated that different nebulizer cups affect the character of the produced aerosol significantly, not only because of the dead volume but also because of the design and construction [ 34 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Compatible Stability and Aerosol Characteristics of Atrovent® (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine

Chen

Zhang

et al. 2020

Pharmaceutics

View full text Add to dashboard Cite

(1) Background: It is common practice in the treatment of respiratory diseases to mix different inhalation solutions for simultaneous inhalation. At present, a small number of studies have been published that evaluate the physicochemical compatibility and aerosol characteristics of different inhalation medications. However, none of them studied Atrovent®. Our work aims to address the lack of studies on Atrovent®. (2) Methods: Portions of admixtures were withdrawn at certain time intervals after mixing and were tested by pH determination, osmolarity measurement, and high-performance liquid chromatography (HPLC) assay of each active ingredient as measures of physicochemical compatibility. The geometrical and aerosol particle size distribution, active drug delivery rate, and total active drug delivered were measured to characterize aerosol behaviors. (3) Results: During the testing time, no significant variation was found in the pH value, the osmotic pressure, or the active components of admixtures. With the increase in nebulization volume after mixing, fine particle dose (FPD) and total active drug delivered showed statistically significant improvements, while the active drug delivery rate decreased compared to the single-drug preparations. (4) Conclusions: These results endorse the physicochemical compatibility of Atrovent® over 1 h when mixed with other inhalation medications. Considering aerosol characteristics, simultaneous inhalation is more efficient.

show abstract

“…The advantages of VMNs are: (i) low drug losses, (ii) narrow droplet size distribution in the aerosol cloud, and (iii) high predicted lung deposition [ 10 ]. However, there are still not too many pre-clinical and clinical studies of BUD micro-suspensions delivered from VMNs indexed in the PubMed database [ 11 , 12 , 13 , 14 , 15 , 16 ], and many of such results are available only as abstracts and short communications [ 17 , 18 , 19 , 20 ]. The important difference in nebulizing BUD is that physicochemical properties of steroid suspensions are different from typical drugs available as solutions [ 18 ], and a thorough recognition and understanding of this process are needed to optimize the pharmacological recommendations, especially when using VMNs.…”

Section: Introductionmentioning

confidence: 99%

Influence of Physicochemical Properties of Budesonide Micro-Suspensions on Their Expected Lung Delivery Using a Vibrating Mesh Nebulizer

et al. 2023

View full text Add to dashboard Cite

The efficiency of lung drug delivery of nebulized drugs is governed by aerosol quality, which depends both on the aerosolization process itself but also on the properties of aerosol precursors. This paper determines physicochemical properties of four analogous micro-suspensions of a micronized steroid (budesonide, BUD) and seeks relationships between these properties and the quality of the aerosol emitted from a vibrating mesh nebulizer (VMN). Despite the same BUD content in all tested pharmaceutical products, their physicochemical characteristics (liquid surface tension, viscosity, electric conductivity, BUD crystal size, suspension stability, etc.) are not identical. The differences have a weak influence on droplet size distribution in the mists emitted from the VMN and on theoretical (calculated) regional aerosol deposition in the respiratory system but, simultaneously, there is an influence on the amount of BUD converted by the nebulizer to aerosol available for inhalation. It is demonstrated that the maximum inhaled BUD dose is below 80–90% of the label dose, depending on the nebulized formulation. It shows that nebulization of BUD suspensions in VMN is sensitive to minor dissimilarities among analogous (generic) pharmaceutics. The potential clinical relevance of these findings is discussed.

show abstract

Effects of flow pattern, device and formulation on particle size distribution of nebulized aerosol

Cited by 14 publications

References 34 publications

Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects

Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects

Compatible Stability and Aerosol Characteristics of Atrovent® (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine

Influence of Physicochemical Properties of Budesonide Micro-Suspensions on Their Expected Lung Delivery Using a Vibrating Mesh Nebulizer

Contact Info

Product

Resources

About