1983
DOI: 10.1093/oxfordjournals.eurheartj.a061472
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Effects of flecainide on electrophysiological properties of accessory pathways in the Wolff-Parkinson-White syndrome

Abstract: The effect of flecainide in 12 patients with the Wolff-Parkinson-White syndrome was analyzed with respect to the anterograde and retrograde conduction properties of the accessory pathway, the modes of initiation and termination of circus movement tachycardias, and the ventricular response during induced atrial fibrillation. The principal effect of this drug was to depress both anterograde and retrograde conduction of the accessory pathway. In 8/9 cases circus movement tachycardia was terminated by prolongation… Show more

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Cited by 50 publications
(7 citation statements)
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“…Our findings of preferential loss of antegrade conduction over the AP, with prolongation of the V-A interval during tachycardia, are consistent with the findings of Neuss et al 8 These investigators showed that flecainide abolished antegrade conduction over the AP in 7 out of 12 patients. In contrast, retrograde conduction was eliminated in only 1 patient.…”
Section: Discussionsupporting
confidence: 93%
“…Our findings of preferential loss of antegrade conduction over the AP, with prolongation of the V-A interval during tachycardia, are consistent with the findings of Neuss et al 8 These investigators showed that flecainide abolished antegrade conduction over the AP in 7 out of 12 patients. In contrast, retrograde conduction was eliminated in only 1 patient.…”
Section: Discussionsupporting
confidence: 93%
“…In none of the cases was a shortening of the anterograde refractory period measured, even when repeated testing at different cycle lengths was performed. Our measurements confirmed findings of other studies investigating the effect of flecainide on atrial fibrillation complicating the WPW syndrome (Neuss et al, 1983), but to our knowledge, no similar drug with such consistent effect of acute intravenous application is yet known. Most drugs lengthen accessory pathway refractory period in relation to the basic value, and therefore, are of little use in pa-tients with very sholt refractory periods, such as the selected group of patients reported upon here (Wellens et al, 1980).…”
Section: Discussionsupporting
confidence: 91%
“…It has been found effective in treatment and prophylaxis of ventricular arrhythmias and certain supraventricular arrhythmias (Anderson et al, 1981;Duff et al, 1981;Campbell, 1983b;Neuss et al, 1983;Hodges & Heel, 1985;Somberg & Tepper, 1986). Like other class Ic agents, flecainide exhibits not only very potent antiarrhythmic but unfortunately also proarrhythmic properties (CAST, 1989).…”
Section: Introductionmentioning
confidence: 99%