Effects of flavonoids on α-glucosidase activity: Potential targets for glucose homeostasis

Pereira, Danielle Fontana; Cazarolli, Luisa Helena; Lavado, Cristiane; Mengatto, Vanessa; Figueiredo, Mariana Sarto; Guedes, Alessandro; Pizzolatti, Moacir Geraldo; Silva, Fátima Regina Mena Barreto

doi:10.1016/j.nut.2011.01.008

Cited by 163 publications

(54 citation statements)

References 29 publications

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“…This is in agreement with a recent report of the α -amylase and α -glucosidase inhibitory activities in other flavonoids [35–37]. Compounds 1 , 8 , and 9 showed moderate inhibitory effects against α -amylase and α -glucosidase, when compared with those of a standard reference drug, acarbose, with IC 50 values of 124.0 ± 21.3 μ g/mL (against α -amylase) and 642.6 ± 46.4 μ g/mL (against α -glucosidase).…”

Section: Resultssupporting

confidence: 94%

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

Thao

Binh

Luyen

et al. 2018

Journal of Analytical Methods in Chemistry

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As part of an ongoing search for new natural products from medicinal plants to treat type 2 diabetes, two new compounds, a megastigmane sesquiterpenoid sulfonic acid (1) and a new cyclohexylethanoid derivative (2), and seven related known compounds (3–9) were isolated from the leaves of Wedelia chinensis (Osbeck.) Merr. The structures of the compounds were conducted via interpretation of their spectroscopic data (1D and 2D NMR, IR, and MS), and the absolute configurations of compound 1 were determined by the modified Mosher's method. The MeOH extract of W. chinensis was found to inhibit α-amylase and α-glucosidase inhibitory activities as well as by the compounds isolated from this extract. Furthermore, compound 7 showed the strongest effect with IC50 values of 112.8 ± 15.1 μg/mL (against α-amylase) and 785.9 ± 12.7 μg/mL (against α-glucosidase). Compounds 1, 8, and 9 showed moderate α-amylase and α-glucosidase inhibitory effects. Other compounds showed weak or did not show any effect on both enzymes. The results suggested that the antidiabetic properties from the leaves of W. chinensis are not simply a result of each isolated compound but are due to other components such as the accessibility of polyphenolic groups to α-amylase and α-glucosidase activities.

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Section: Resultssupporting

confidence: 94%

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

Thao

Binh

Luyen

et al. 2018

Journal of Analytical Methods in Chemistry

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“…Although the composition of polyphenols in the vegetable juice was not clear in this study, it might contain polyphenols as naringenin, chlorogenic acid, quercetin, and kaempferol because they are present in tomato (the major ingredient of the vegetable juice) [31] [32]. These polyphenols can suppress the activities of α-amylase and α-glucosidase [33]- [35], and inhibit SGLT 1 [36]- [38]. Thus, it is possible that the organic acids and polyphenols in the vegetable juice may slow glucose absorption by suppressing the activities of α-amylase, α-glucosidase, and SGLT 1.…”

Section: Discussionmentioning

confidence: 83%

Prior or Concomitant Drinking of Vegetable Juice with a Meal Attenuates Postprandial Blood Glucose Elevation in Healthy Young Adults

Kasuya¹,

Okuyama²,

Yoshida³

et al. 2016

FNS

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Controlling postprandial blood glucose levels can prevent and improve lifestyle-related diseases. We aimed to evaluate the effects of a commercially available vegetable juice, which is a convenient alternative to vegetables, on postprandial glucose elevation. In test 1, we confirmed the appropriate timing to consume the vegetable juice (200 mL), and demonstrated that postprandial glucose elevation was attenuated by drinking the vegetable juice with or before the experimental meal. The change in maximum concentration (ΔCmax) of blood glucose was the lowest when the vegetable juice was consumed at 30 min before the meal. In test 2, we confirmed the necessary ingestion volumes of vegetable juice (range: 68.5 -274 mL) for attenuating the response to 50 g of carbohydrates. After drinking 200 mL of vegetable juice, the ΔCmax and incremental area under the curve values for blood glucose were significantly lower than those for after drinking the same volume of water (p < 0.05). However, a greater volume of vegetable juice did not provide an additive effect. Our results suggest that approximately 200 mL of vegetable juice at 30 min before meals is the most effective method for using vegetable juice to suppress postprandial blood glucose elevation. Stimulation of insulin secretion due to the pre-meal vegetable juice intake may contribute to this effect, although further studies are needed to identify the detailed mechanism for the attenuation.

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“…Our results showed that the inhibitory activity of the tested plants against both α-glucosidase and pancreatic α-amylase was positively correlated with the total phenolic compounds contents. Similarly, some studies have shown that the inhibitory activities of plant-based extracts or products against α-glucosidase and pancreatic α-amylase can be linked to the total phenolic compounds and flavonoids contents [52,53]. These correlations may indicate the importance of phenolic compounds as mediators for the inhibitory effects of plant-based foods on α-amylase and α-glucosidase.…”

Section: Discussionmentioning

confidence: 96%

Total Phenolics, Antioxidant Activity and Anti-Diabetic Capacities of Selected Iraqi Medicinal Plants

Molan¹,

Mahdy²

2016

AJLSR

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Introduction: In Iraq, medicinal plants have not received much attention in terms of quantifying their antioxidant and other biological/pharmacological activities so the objective of the present study was to assess the antioxidant activity of selected medicinal plants grown in Iraq and relate it to their total phenolic contents and their inhibitory effect on carbohydrate-hydrolyzing enzymes. Methods: Antioxidant activity was assessed by ferric reducing antioxidant power (FRAP) and oxygen reactive absorbance capacity (ORAC) methods. The possible inhibitory effect on carbohydrate-hydrolyzing enzymes was also investigated. Results: In almost all the parameters used, the aqueous extracts from Mentha piperita showed significantly higher (P < 0.0001) activities than other plants. Antioxidant activity was significantly correlated (P < 0.0001) with TPC among all the plants studied. In addition, the plant extracts showed strong inhibition against pancreatic α-amylase and yeast α-glucosidase. Only Cyperus rotundus and Prosopis farcta have been used traditionally for the treatment of diabetes in Iraq. Conclusions:In conclusion, to the best of our knowledge, the remaining four plants and herbs (Glycyrrhiza glabra, H. Sabdariffa, Matricaria chamomilla, and M. piperita) have no records in the literature for their antidiabetic effects. Consequently, this study identifies these four medicinal plants as novel inhibitors of key enzymes (α-glucosidase and α-amylase) relevant for type 2 diabetes that showed even higher activity than the currently being used for the treatment of diabetes by the Iraqi herbalists.

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Effects of flavonoids on α-glucosidase activity: Potential targets for glucose homeostasis

Abstract: Based on these results, we can conclude that disaccharidases are targets of flavonoids in the regulation of glucose absorption and consequently glucose homeostasis.

Cited by 163 publications

References 29 publications

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

Prior or Concomitant Drinking of Vegetable Juice with a Meal Attenuates Postprandial Blood Glucose Elevation in Healthy Young Adults

Total Phenolics, Antioxidant Activity and Anti-Diabetic Capacities of Selected Iraqi Medicinal Plants

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