Effects of flavonoids on tongue squamous cell carcinoma

Gutiérrez-Venegas, Gloria; Sánchez-Carballido, Manuel Alejandro; Suárez, Claire Delmas; Gómez-Mora, Juan Arturo; Bonneau, Noémie

doi:10.1002/cbin.11266

Cited by 12 publications

(12 citation statements)

References 112 publications

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“…Wine contains the same flavanol derivatives as green tea, namely catechins; the latter have been extensively studied for their chemo-preventive potential, showing efficacy against multiple cancers including OCC [75,76]. Therefore, it is reasonable to suppose that wine flavanols could have similar OCC protective effects.…”

Section: In Vitro Studiesmentioning

confidence: 99%

Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus

2020

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The health benefits of moderate wine consumption have been extensively studied during the last few decades. Some studies have demonstrated protective associations between moderate drinking and several diseases including oral cavity cancer (OCC). However, due to the various adverse effects related to ethanol content, the recommendation of moderate wine consumption has been controversial. The polyphenolic components of wine contribute to its beneficial effects with different biological pathways, including antioxidant, lipid regulating and anti-inflammatory effects. On the other hand, in the oral cavity, ethanol is oxidized to form acetaldehyde, a metabolite with genotoxic properties. This review is a critical compilation of both the beneficial and the detrimental effects of wine consumption on OCC.

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Section: In Vitro Studiesmentioning

confidence: 99%

Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus

2020

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“…The second most significant hit was 'cell cycle', with an adjusted P-value of 1.6 × 10-4, followed by 'human papillomavirus infection', and 'focal adhesion'. Importantly, numerous experiments demonstrated these pathways affect the occurrence and development of tongue squamous cell carcinoma [94][95][96][97][98]. This use case again demonstrates the practical application of NcPath, which allows for comprehensive analysis using pairings of three RNA classes, and helps researchers focusing on potentially more relevant biological findings.…”

Section: Use Case 2--integrated Lncrna/mirna/gene Analysis In Squamou...mentioning

confidence: 89%

NcPath: A novel tool for visualization and enrichment analysis of human non-coding RNA and KEGG signaling pathways

Chen

Zhang

et al. 2022

Preprint

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Noncoding RNAs play important roles in transcriptional processes and participate in the regulation of various biological functions, in particular miRNAs and lncRNAs. Despite their importance for several biological functions, the existing signaling pathway databases do not include information on miRNA and lncRNA. Here, we redesigned a novel pathway database named NcPath by integrating and visualizing a total of 178,308 human experimentally-validated miRNA-target interactions (MTIs), 36,537 experimentally-verified lncRNA target interactions (LTIs), and 4,879 experimentally-validated human ceRNA networks across 222 KEGG pathways (including 27 sub-categories). To expand the application potential of the redesigned NcPath database, we identified 553,523 reliable lncRNA-PCG interaction pairs by integrating co-expression relations, ceRNA relations, co-TF-binding interactions, co-Histone-modification interactions, cis-regulation relations and lncPro Tool predictions between lncRNAs and protein-coding genes. In addition, to determine the pathways in which miRNA/lncRNA targets are involved, we performed a KEGG enrichment analysis using an hypergeometric test. The NcPath database also provides information on MTIs/LTIs/ceRNA networks, PubMed IDs, gene annotations and the experimental verification method used. In summary, the NcPath database will serve as an important and continually updated platform that provides annotation and visualization of the pathways on which noncoding RNAs (miRNA and lncRNA) are involved, and provide support to multimodal noncoding RNAs enrichment analysis. The NcPath database is freely accessible at http://ncpath.pianlab.cn/.

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“…In this regard, they reported that flavonoids could stop the cell cycle and prevent metastasis, as well as induce apoptosis in cancer cells. As well, since no side effects were seen, they introduced flavonoids as an attractive option for the treatment of tongue cancer [ 19 ]. Similarly, the results of our research show that the use of the antioxidant curcumin, as a preventive and therapeutic agent for oral cancer, can be very effective and efficient.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic effect of topical (slow-release) and systemic curcumin nano-niosome antioxidant on oral cancer in rat

Fazli

Irani

Bardania

et al. 2022

BMC Complement Med Ther

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Background Oral malignancies have a significant effect on the quality of life among the affected patients. Curcumin is an antioxidant with a low bioavailability in the target tissue. Niosomes are carriers of increasing the therapeutic effects of drugs and reducing their side effects. This study aimed to determine the effective dose of curcumin niosome in the culture and then to compare its prophylactic effect in the form of mouthwash with that of its injectable form on oral cancer in rats. Methods This was an in-vitro and in-vivo study. Firstly, KB oral cancer cells and human umbilical vein endothelial cells (HUVEC) were treated in separate groups with free curcumin, curcumin-loaded niosomes, and the unloaded niosomes at four doses of 4, 8, 16, and 32 μg. The study rats were then divided into the following four groups: 1) no intervention, 2) only carcinogenic substance, 3) carcinogenic substance with curcumin-loaded niosome injection, and 4) carcinogenic substance with a mouthwash containing niosome. Results At the cellular level, a dose of 16 μg after 24 h was selected as an effective dose. In the animal phase, the use of injectable curcumin niosome was observed to significantly prevent the development of severe forms of dysplasia. Conclusions In this in-vitro and in-vivo study, curcumin-loaded niosome was effective in preventing the development of severe forms of dysplasia and the inhibition of the growth of cancer cells.

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Effects of flavonoids on tongue squamous cell carcinoma

Cited by 12 publications

References 112 publications

Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus

Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus

NcPath: A novel tool for visualization and enrichment analysis of human non-coding RNA and KEGG signaling pathways

Prophylactic effect of topical (slow-release) and systemic curcumin nano-niosome antioxidant on oral cancer in rat

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