Effects of fish-oil supplementation on myocardial fatty acids in humans

Metcalf, Robert G.; James, Michael J.; Gibson, Robert; Edwards, James; Stubberfield, John; Stuklis, Robert; Roberts‐Thomson, Kurt C.; Young, Glenn D.; Cleland, Leslie G.

doi:10.1093/ajcn/85.5.1222

Cited by 179 publications

(150 citation statements)

References 36 publications

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“…Consistent with this finding, RBC and cardiac/breast tissue EPA content correlate strongly after omega-3 PUFA supplementation in humans [14][15][16], and RBC omega-3 PUFA levels correlate with omega-3 PUFA content in multiple mouse and rat tissues after dietary supplementation [17][18].…”

Section: Discussionsupporting

confidence: 66%

Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases

Watson

Cockbain

Spencer

et al. 2016

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases, Prostaglandins Leukotrienes and Essential Fatty Acids, http://dx.doi.org/10.1016/j.plefa.2016.10.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractWe investigated red blood cell (RBC) PUFA profiles, and the predictive value of RBC EPA content for tumour EPA exposure and clinical outcomes, in the EMT study, a randomised trial of EPA in patients awaiting colorectal cancer (CRC) liver metastasis surgery (A.J. Cockbain et al, 2014). There was a significant increase in RBC EPA in the EPA group (n=43; median intervention 30 days; mean absolute 1.26 [±0.14]% increase; P<0.001), but not in the placebo arm (n=45). EPA incorporation varied widely in EPA users and was not explained by treatment duration or compliance.

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Section: Discussionsupporting

confidence: 66%

Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases

Watson

Cockbain

Spencer

et al. 2016

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…EPA has been associated with a lower incidence of death from CHD and arrhythmias (28) , and it is known that, compared with DHA, EPA is more readily incorporated into human atrial tissue (29) . In animal models, dietary fish oils have been shown to confer resistance to atrial fibrillation (30) .The incorporation of EPA into atrial tissue is thought to be antiarrhythmic by virtue of EPA's ability to displace arachidonic acid, which is known to have pro-arrhythmic properties (31,32) .…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich fish oil supplementation

et al. 2009

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Heart rate (HR) variability and large arterial compliance can be improved using fish oils. DHA, a component of fish oil, has cardiovascular health benefits, but its effect on HR variability (HRV) and arterial compliance is yet to be quantified. Sixty-seven overweight or obese adults (thirty-six males and thirty-one females; 53 (SEM 2) year; BMI 31·7 (SEM 1·1) kg/m 2 ) were randomly allocated to consume either 6 g/d sunola oil (control; n 17), fish oil (260 mg DHA þ 60 mg EPA per g) at doses of 2 g/d (n 16), 4 g/d (n 17) or 6 g/d (n 17). Blood pressure, HR and compliance of large and small arteries were measured while supine at baseline and after 12 weeks in all participants, and HRV was assessed in a subgroup of forty-six participants. There was no effect of fish oil on blood pressure, small artery compliance or HR. However, the low frequency:high frequency ratio of HRV decreased with increasing doses of fish oil (r 20·34, P¼0·02), while large artery compliance increased (r 0·34, P¼ 0·006). Moreover, the changes in these biomarkers were significantly correlated (r 2 0·31, P¼ 0·04) and may reflect fish oil-induced improvements in arterial function and cardiac autonomic regulation.

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“…This might be because DHA has a limited ability to accumulate in cardiac tissue in chickens. This contrasts with the fatty acid patterns in human hearts where the level of EPA is normally around 0.5% and DHA is nearly 5% of the total fats (Metcalf et al, 2007). Feeding fish oil to human subjects has been shown to increase EPA and DHA levels markedly but feeding ALA rich flax oil had no effect (Metcalf et al, 2007).…”

Section: Heart Tissue Fatty Acidsmentioning

confidence: 93%

The Effect of Diet Containing High Alpha-Linolenic Acid on Omega-3 Fatty Acids and Health Status of the Heart in Broilers

Kartikasari¹,

Hughes

Geier

et al. 2017

BuletinPeternak

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The objective of the study was to examine the effects of diet containing high alpha-linolenic acid (ALA) on omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) and the health status of heart in broilers. Diets were based on a commercial starter diet, with a low level of fat. The experimental diets contained two levels of ALA (2.23 and 19.37%), with the total fat content was approximately 5%. Pure or blended vegetable oils were included at a level of 2.8% in order to produce diets with the desired levels of linoleic acid (LA) and ALA. The ratio of LA to ALA of the diets was 9.75:1 for low ALA diet and 1.37:1 for high ALA diet. Each diet was provided ad libitum for the duration of the 28-d growth period. A total of 32 one-day-old chicks housed in four pens (n=8 birds/pen). At 28 days of age, six selected birds from each pen were weighed individually and hearts were collected for analysis. A ratio of right ventricle mass (RV) to total ventricle mass (TV) was used to indicate the health status of the heart. Results showed that dietary treatment increased the level of ALA in heart tissue from 0.1% (low ALA diet) to 0.5% (P<0.01). Increasing levels of dietary ALA raised the level of n-3 LCPUFA and total n-3 in heart tissues by 4-5-fold. There was no significant difference observed in the level of heart LA, arachidonic acid (AA) and total n-6. The increased levels of dietary ALA did not cause changes in the ratio of RV to total TV. In conclusion, it appears clear that based on our data, increasing ALA content in the diet of chickens could potentially be beneficial for the health of the birds; however, further work is necessary.(Keywords: Alpha-linolenic acid, Chicken heart, Health status, Omega-3 fatty acids) ALA (2,23 and 19,37%) INTISARI Penelitian dilakukan untuk mengetahui pengaruh pakan yang kaya akan kandungan asam alphalinolenat (alpha-linolenic acid, ALA, asam lemak n-3) terhadap kandungan asam lemak tak jenuh omega-3 rantai panjang (n-3 LCPUFA) dan status kesehatan jantung ayam. Pakan yang diberikan didasarkan pada pakan starter komersial yang mengandung lemak rendah. Pakan perlakuan terdiri dari dua aras

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Effects of fish-oil supplementation on myocardial fatty acids in humans

Abstract: The results of the present study show that dietary n-3 fatty acids are rapidly incorporated into human myocardial phospholipids at the expense of arachidonic acid during high-dose fish-oil supplementation.

Cited by 179 publications

References 36 publications

Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases

Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases

Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich fish oil supplementation

The Effect of Diet Containing High Alpha-Linolenic Acid on Omega-3 Fatty Acids and Health Status of the Heart in Broilers

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