Effects of fish oil supplementation in rheumatoid arthritis.

Tempel, Hille van der; Tulleken, J. E.; Limburg, P. C.; Muskiet, Frits A. J.; Rijswijk, M.H. van

doi:10.1136/ard.49.2.76

Cited by 161 publications

(59 citation statements)

References 35 publications

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“…The total daily dose of the fish oil supplement for each patient was 6 gm. The coconut oil capsules consisted primarily of 8:O (octanoic acid; 63 moles%) and 10:0 (decanoic acid; 36 moles%) fatty acids (3). The a-tocopherol content of the fish oil capsules was 5 pmoles/ml of oil (12.9 mg of a-tocopherol daily), and the total a-tocopherol content of the coconut oil capsules was 4 pmoles/ml of oil (10.3 mg of a-tocopherol daily).…”

Section: Methodsmentioning

confidence: 99%

Vitamin e status during dietary fish oil supplementation in rheumatoid arthritis

Tulleken

Limburg

Muskiet

et al. 1990

Arthritis & Rheumatism

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The primary objective of this study was to determine whether it is the fish oil itself or the α‐tocopherol that is added to the fish oil preparations (to prevent peroxidation) that is responsible for the beneficial effects of dietary supplementation with fish oil in patients with rheumatoid arthritis (RA). One group of RA patients took fish oil supplements and another group took α‐tocopherol‐enriched coconut oil supplements (placebo controls), both for 3 months. Clinical and laboratory indices of RA activity in relation to cellular and plasma vitamin E levels were assessed at the beginning and the end of the trial. The results of the study provide evidence that the beneficial effects of fish oil supplementation cannot be ascribed to the antioxidizing properties of the α‐tocopherol per se.

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Section: Methodsmentioning

confidence: 99%

Vitamin e status during dietary fish oil supplementation in rheumatoid arthritis

Tulleken

Limburg

Muskiet

et al. 1990

Arthritis & Rheumatism

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“…Several studies have reported anti-inflammatory effects of fish oil in patients with RA, such as decreased LTB 4 production by neutrophils (74)(75)(76)(77) and monocytes (76,78) , decreased PGE 2 production by mononuclear cells (79) , decreased IL-1 production by monocytes (80) , decreased plasma IL-1b concentrations (81) , decreased serum C-reactive protein concentrations (74,82) and normalisation of the neutrophil chemotactic response (83) . A number of randomised placebo-controlled double-blind studies of fish oil in RA have been reported.…”

Section: Trials Of N-3 Pufa In Rheumatoid Arthritismentioning

confidence: 99%

Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’ PUFA, inflammatory processes and rheumatoid arthritis

Calder

2008

Proc. Nutr. Soc.

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease manifested by swollen and painful joints, bone erosion and functional impairment. The joint lesions are characterised by infiltration of T lymphocytes, macrophages and B lymphocytes into the synovium and by synovial inflammation involving eicosanoids, cytokines and matrix metalloproteinases. In relation to inflammatory processes, the main fatty acids of interest are the n-6 PUFA arachidonic acid, which is the precursor of inflammatory eicosanoids such as PGE2 and leukotriene B4, and the n-3 PUFA EPA and DHA, which are found in oily fish and fish oils. Eicosanoids derived from the n-6 PUFA arachidonic acid play a role in RA, and the efficacy of non-steroidal anti-inflammatory drugs in RA indicates the importance of pro-inflammatory cyclooxygenase pathway products of arachidonic acid in the pathophysiology of the disease. EPA and DHA inhibit arachidonic acid metabolism to inflammatory eicosanoids. EPA also gives rise to eicosanoid mediators that are less inflammatory than those produced from arachidonic acid and both EPA and DHA give rise to resolvins that are anti-inflammatory and inflammation resolving. In addition to modifying the lipid mediator profile, n-3 PUFA exert effects on other aspects of immunity relevant to RA such as antigen presentation, T-cell reactivity and inflammatory cytokine production. Fish oil has been shown to slow the development of arthritis in an animal model and to reduce disease severity. Randomised clinical trials have demonstrated a range of clinical benefits in patients with RA that include reducing pain, duration of morning stiffness and use of non-steroidal anti-inflammatory drugs.

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“…Beneficial effects of dietary supplementation with 0 3 have been demonstrated in some (4-7), but not all (8), animal models of inflammatory disease and in (mainly short-term) clinical studies in patients with rheumatoid arthritis (RA) (9)(10)(11)(12)(13)(14)(15)(16)(17). Long-term data in humans are presently scarce (18).…”

mentioning

confidence: 99%

Long‐term effect of omega‐3 fatty acid supplementation in active rheumatoid arthritis

Geusens

Wouters

Nijs

et al. 1994

Arthritis & Rheumatism

234

108

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Objective. To study the long-term effects of supplementation with omega-3 fatty acids (03) in patients with active rheumatoid arthritis.Methods. Ninety patients were enrolled in a 12-month, double-blind, randomized study comparing daily supplementations with either 2.6 gm of 03, or 1.3 gm of 0 3 + 3 gm of olive oil, or 6 gm of olive oil.Results. Significant improvement in the patient's global evaluation and in the physician's assessment of pain was observed only in those taking 2.6 gdday of d. The proportions of patients who improved and of those who were able to reduce their concomitant antirheumatic medications were significantly greater with 2.6 gmlday of 03.Conclusion. Daily supplementation with 2.6 gm of 0 3 results in significant clinical benefit and may reduce the need for concomitant antirheumatic medication.

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Effects of fish oil supplementation in rheumatoid arthritis.

Cited by 161 publications

References 35 publications

Vitamin e status during dietary fish oil supplementation in rheumatoid arthritis

Vitamin e status during dietary fish oil supplementation in rheumatoid arthritis

Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’ PUFA, inflammatory processes and rheumatoid arthritis

Long‐term effect of omega‐3 fatty acid supplementation in active rheumatoid arthritis

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