Effects of fish oil on hypertension, plasma lipids, and tumor necrosis factor-α in rats with sucrose-induced metabolic syndrome

Aguilera, Alfonso; Díaz, Guillermo Hernández; Barcelata, Martín Lara; Guerrero, Ofelia Angulo; Oliart-Ros, Rosa María

doi:10.1016/j.jnutbio.2003.12.008

Cited by 88 publications

(28 citation statements)

References 60 publications

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“…The levels of triglycerides, total cholesterol and HDL were lower in animals receiving the enhanced diet (Table 5). Positive effects of ω-3 fatty acids on the reduction of triglycerides and total cholesterol serum levels have been reported in several other studies using animal or human models (2,33) . Omega-3 fatty acids can inhibit the activity of diacylglycerol acyltransferase-a catalyst of triglyceride synthesis (35) .…”

Section: Discussionsupporting

confidence: 62%

Hepatic and biochemical repercussions of a polyunsaturated fat-rich hypercaloric and hyperlipidic diet in Wistar rats

Burlamaqui

Dornelas

Valença

et al. 2011

Arq. Gastroenterol.

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-Context -Non-alcoholic fatty liver disease is characterized by lipid deposits in the hepatocytes and has been associated with obesity, dyslipidemia and type-2 diabetes. It is considered a hepatic manifestation of the metabolic syndrome, of which the main component is insulin resistance leading to hyperinsulinemia and increased production of inflammatory cytokines. Saturated fat promotes hypertriglyceridemia and hyperinsulinemia, reduces levels of high-density cholesterol and increases levels of low-density cholesterol, while polyunsaturated fat is associated with hypolipidemic, antiinflammatory and imunoregulating action. ObjectiveTo evaluate the hepatic and biochemical repercussions of a polyunsaturated fat-rich diet in Wistar rats. Methods -Twenty-two rats were distributed equally in two groups: GI -standard diet (Biobase Bio-tec Ratos e Camundongos ® ) providing 3.000 kcal/kg and GII -hypercaloric and hyperlipidic diet providing 4.250 kcal/kg (ω-6:ω-3 = 3:1). The animals were euthanized after 23 weeks of experiment. The weight, biochemical parameters and hepatohistological changes were registered. Results -Findings were submitted to variance analysis with the level of statistical significance at 5%. The average weight did not differ significantly between the groups at baseline (P = 0.711), but was greater in Group II by the end of the experiment (P = 0.000). The levels of triglycerides (P = 0.039), total cholesterol (P = 0.015) and HDL (P = 0.005) were higher in Group I than in Group II. Macrovesicular steatosis was significantly more common in Group II than in Group I (P = 0.03). Conclusion -Hypercaloric and hyperlipidic diet rich in polyunsaturated fat promotes weight gain and favors the development of hepatic steatosis while reducing serum levels of triglycerides, total cholesterol and HDL.

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Section: Discussionsupporting

confidence: 62%

Hepatic and biochemical repercussions of a polyunsaturated fat-rich hypercaloric and hyperlipidic diet in Wistar rats

Burlamaqui

Dornelas

Valença

et al. 2011

Arq. Gastroenterol.

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“…Furthermore, in a recent study, rats fed with high sucrose for 16 weeks showed a decreased SERCA2a activity, which was mediated by elevated oxidative stress produced in the MetS heart (Tang et al 2010). It should be taken into consideration some important differences in underlying mechanisms of cardiac dysfunction in MetS-rats, most probably due to variation of the metabolic changes associated with different strains of rat used, as well as the mode, amount, and duration of sucrose feeding, although all animals in these studies have common parameters such as increased body weight and blood glucose level, insulin resistance and similar structural alterations in heart tissue (Aguilera et al 2004;Chen et al 2011;Misra et al 1999;Panchal and Brown 2011).…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction

Okatan

Durak

Turan

2016

Can. J. Physiol. Pharmacol.

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“…It has been well documented that when fed with a highsucrose diet, rats develop the syndrome of Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in a relatively short time (Buňag et al, 1983;Wright et al, 1983;Reaven and Ho, 1991;Baňos et al, 1997;Oliart-Ros et al, 2001;Aguilera et al, 2004). These metabolic changes are intimately associated with an increase in systolic blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats

Pang

Zhao

Wen

et al. 2008

Journal of Ethnopharmacology

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Effects of fish oil on hypertension, plasma lipids, and tumor necrosis factor-α in rats with sucrose-induced metabolic syndrome

Cited by 88 publications

References 60 publications

Hepatic and biochemical repercussions of a polyunsaturated fat-rich hypercaloric and hyperlipidic diet in Wistar rats

Hepatic and biochemical repercussions of a polyunsaturated fat-rich hypercaloric and hyperlipidic diet in Wistar rats

Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction

Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats

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