Effects of finasteride on the morphology of polycystic ovaries

Arie, Wilson Maça Yuki; Bagnoli, Vicente Renato; Fonseca, Ângela Maggio da

doi:10.1016/j.ijgo.2004.05.017

Cited by 3 publications

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References 3 publications

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“…In a population study in 2004, 31 PCOS women were given oral finasteride or the same dose of placebo. The experiment concluded that the PCOS women who took finasteride did not show a significant difference in ovarian capacity compared with the control group [33]. In our study, the PCOS rats in the P-FEx group showed a significant reduction in the area of the corpus luteum.…”

Section: Discussionmentioning

confidence: 41%

Effects of Exercise Combined with Finasteride on Hormone and Ovarian Function in Polycystic Ovary Syndrome Rats

Jiang

Wei

et al. 2019

International Journal of Endocrinology

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Exercise can reduce androgen and insulin levels in polycystic ovary syndrome (PCOS) patients. Finasteride is also presumed to improve the developing follicle environment. Therefore, the aim of this study was to observe the effects of the combination of exercise and finasteride therapy on hormone levels and ovarian morphology in rats with polycystic ovary syndrome. Forty female rats were randomly divided into five groups (n=8 each group): the PCOS sedentary group (P-Sed), PCOS exercise group (P-Ex), PCOS finasteride and sedentary group (P-FSed), and PCOS finasteride and exercise group (P-FEx), and healthy, age-matched rats were used as controls (CO). The results indicated that the levels of FINS in the P-FEx group were significantly lower than those in the P-Sed and P-FSed groups, while the ratio of fasting blood glucose (FBG)/fasting serum levels of insulin (FINS) in the P-FEx group was significantly higher than that in the P-Sed and P-FSed groups. Compared to the P-FEx group, serum levels of TT (total testosterone) in the P-Sed and P-FSed groups were significantly increased. The thickness of the follicular membrane and the number of atresia follicles in the P-FEx and CO groups were significantly lower than those in the P-Sed group, but there was no significant difference between the P-Ex and P-Sed groups. These results show that the combined usage of exercise and finasteride does not alter the effects of exercise on increasing insulin sensitivity and reducing androgen levels. There is also a synergistic effect of exercise and finasteride on the morphology of the ovary, including a reduced number of atresia follicles and thickness of the follicular membrane.

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Section: Discussionmentioning

confidence: 41%

Effects of Exercise Combined with Finasteride on Hormone and Ovarian Function in Polycystic Ovary Syndrome Rats

Jiang

Wei

et al. 2019

International Journal of Endocrinology

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“…In a double‐blind RCT, administration of finasteride with recombinant FSH (rFSH) during ovarian stimulation improved the ovulation rate in hyperandrogenic anovulatory women with PCOS and prior resistance to gonadotropin stimulation . Another RCT used ultrasound‐guided assessment to demonstrate no differences in volume and number of cysts in ovaries of women treated with finasteride (5 mg/day) after 3 months …”

Section: Resultsmentioning

confidence: 99%

“…71 Another RCT used ultrasound-guided assessment to demonstrate no differences in volume and number of cysts in ovaries of women treated with finasteride (5 mg/day) after 3 months. 72 Hidradenitis suppurativa A couple case series examined finasteride (5 mg/day) for hidradenitis suppurativa (HS) therapy. 42,[73][74][75][76] Five women and two men with HS unresponsive to antibiotics were treated with finasteride.…”

Section: Acnementioning

confidence: 99%

The efficacy and use of finasteride in women: a systematic review

Chapman

Mesinkovska

2019

Int J Dermatology

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Background Physicians are beginning to use finasteride as treatment for hair loss, hirsutism, and various other dermatologic conditions in women. However, the reported efficacy and use of finasteride in the female population varies widely. The purpose of this study is therefore to better define the efficacy and use of finasteride in women and identify research gaps that require further investigation. Methods A systematic review of the current literature describing finasteride use in women. Results A total of 2,683 patients participated in 65 studies involving finasteride use in women published between January 1997 and July 2017. Most randomized controlled trials (RCTs) evaluated finasteride use in women with hirsutism (48.7%) or female pattern hair loss (34.7%). RCTs recommend finasteride treatment for women with hirsutism or polycystic ovarian syndrome. Meanwhile, other forms of hair loss were studied such as alopecia, lichen planopilaris, and frontal fibrosing alopecia, but no RCTs evaluating finasteride therapy were identified. Other prospective and retrospective studies report that finasteride may improve hair loss in women with female pattern hair loss or frontal fibrosing alopecia. Overall, doses of oral finasteride ranged from 0.5 to 5 mg/day, in females aged 6–88, over a duration of 6–12 months (57.6%), as monotherapy (88.9%), and for continuous use (96.4%). Conclusion The studies reviewed highlight the finasteride dosage, length of treatment, and candidate conditions that can benefit from finasteride therapy. Future long‐term studies are necessary to fully assess the therapeutic mechanisms and potential consequences of finasteride use and to optimize treatment protocols.

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Comportamento sexual de mulheres com síndrome dos ovários policísticos

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Agradeço a DEUS pelo "dom da VIDA", pela bondade infinita e pela família que me deste.Sou muito grata ao meu esposo Edésio V. Silva Filho que tem me estimulado em todas as etapas de minha vida acadêmica e à minha filha Larissa pela sua existência, sua luz e seu sorriso. Ambos acompanharam esta caminhada do início ao fim, compartilhando os momentos difíceis e as vitórias acumuladas ao longo deste estudo, com paciência e tolerância.À minha mãe, Maria Rosa, e toda querida família, pelo amor, crença, compreensão e alegria que me infundiram a confiança necessária para realizar os meus sonhos.Às pacientes que participaram, com muita disposição, desse estudo e que continuam me ajudando com suas experiências a construir um olhar mais aprofundado da sexualidade. À Professora Angela Maggio da Fonseca, exemplo de dedicação, de doação, de dignidade pessoal e sobretudo de amor. Meu sincero agradecimento pelos incontáveis encontros e discussões, pela hospitalidade na intimidade de sua casa. Sou inteiramente grata por essa orientação que ultrapassa a tese.Ao Professor Vicente Renato Bagnoli sou imensamente grata pelo seu bom humor, pelo incentivo e pela ajuda através da leitura, comentários e observações críticas a respeito do texto.Ao Professor Edmund Chada Baracat, bem como, aos Doutores Elsa Aida Gay de Pereyra e Gustavo Arantes Rosa Maciel, meus agradecimentos pela disposição para discutir, pelos questionamentos e contribuições na etapa da qualificação, que muito contribuíram para essa forma final da tese.Aos colegas do Ambulatório de Ginecologia Endócrina e Climatério do HCFMUSP, em particular à amiga Ana Lúcia Cavalcanti, também companheira dessa aventura singular, pela indescritível solidariedade, afeto e capacidade de ouvir que se traduziram sempre em conforto e amadurecimento.Aos amigos que, mesmo não citados individualmente, sabem da importância deles nesta e em outras etapas deste processo. Sabem o afeto, respeito e torcida mútua que temos.

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Effects of finasteride on the morphology of polycystic ovaries

Cited by 3 publications

References 3 publications

Effects of Exercise Combined with Finasteride on Hormone and Ovarian Function in Polycystic Ovary Syndrome Rats

Effects of Exercise Combined with Finasteride on Hormone and Ovarian Function in Polycystic Ovary Syndrome Rats

The efficacy and use of finasteride in women: a systematic review

Comportamento sexual de mulheres com síndrome dos ovários policísticos

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