Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer

Peng, Tao; Sun, Yangyang; Lv, Zhiwei; Zhang, Ze; Su, Qiuju; Wu, Hao; Zhang, Wei; Yuan, Wei; Zuo, Li; Shi, Li; Zhang, Lifeng; Zhou, Xiaoli; Mi, Yuanyuan

doi:10.1038/s41598-020-80146-y

Cited by 14 publications

(18 citation statements)

References 38 publications

(16 reference statements)

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“…In the stratified analysis by cancer type, we observed that the C1208T variant was correlated with increased risk of urinary, breast, and digestive cancers. For lung cancer, individuals with the TT genotype had a 30% decreased risk compared to those with the CC genotype, consistent with the reports in previous studies by Peng et al [37]. In the subgroup analysis by race, no positive results were demonstrated in participants of European or African descent.…”

Section: Discussionsupporting

confidence: 91%

“…Genetic polymorphisms of CXCR2 may influence the function of the protein by regulating gene expression. Several previous studies have investigated the correlation of CXCR2 mutations with risk of cancer [32][33][34][35][36][37][38]. However, the conclusions of these studies were not consistent.…”

Section: Discussionmentioning

confidence: 93%

“…Ryan et al [36] evaluated the CXCR2 polymorphism in Indians and revealed that C1208T was associated with an increased risk of bladder cancer (P = 0:003, OR = 1:29). Peng et al [37] assessed the CXCR2 variant in two independent populations (European and Asian) and found that C1208T was associated with a reduced risk of lung cancer. In 2017, Yang et al [48] performed a meta-analysis and indicated that CXCR2 expression in tumor tissues was correlated with poor prognosis in solid tumor patients.…”

Section: Discussionmentioning

confidence: 99%

“…Five genetic models were adopted to evaluate the overall ORs. For the CXCR2 C1208T polymorphism, the five models were allelic contrast (T allele vs. C allele), heterozygous comparison (TC vs. CC), homozygous model (TT vs. CC), dominant (TT+TC vs. CC), and recessive (TT vs. TC+CC) model [37,38]. A Q statistic test was used to calculate the heterogeneity among the included studies.…”

Section: Data Extraction Study Characteristics Were As Followsmentioning

confidence: 99%

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Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility

Zhou

et al. 2021

Journal of Immunology Research

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Background. The CXC chemokines belong to a unique family of cytokines that participates in the progression and development of many malignant tumors. Evidence for the relationship between chemokine (C-X-C motif) receptor 2 (CXCR2) C1208T polymorphism and susceptibility to cancer remains inconsistent. Methods. Odds ratios (ORs), 95% confidence intervals (CIs), and combined analysis were used to investigate the effect of CXCR2 variation on cancer risk. Gene Set Enrichment Analysis (GSEA) and enzyme-linked immunosorbent assay (ELISA) were also used to evaluate the expression of CXCR2 in prostate cancer (PCA). Results. Across 11 case-control studies, 4,909 cases and 5,884 controls were involved in the current analysis. Individuals with a TT genotype were associated with increased risk of digestive cancer, compared to those with a TC+CC genotype ( OR = 1.16 , 95 % CI = 1.02 -1.31, P = 0.025 ). Individuals carrying the TT genotype had a 39% higher risk of urinary cancer than those carrying CC genotype ( OR = 1.39 , 95 % CI = 1.04 -1.87, P = 0.025 ). Individuals with a TT genotype showed a 56% augmented breast cancer risk, compared to those with a CC genotype ( OR = 1.56 , 95 % CI = 1.03 -2.35, P = 0.034 ). It was found that CXCR2 expression was downregulated in PCA. Compared with PCA subjects carrying the CC genotype, the expression of CXCR2 was decreased in patients with the TT genotype. Conclusions. The CXCR2 C1208T variation was associated with elevated risk of urinary, breast, and digestive cancer. However, the C1208T polymorphism was correlated with attenuated risk of lung cancer.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Data Extraction Study Characteristics Were As Followsmentioning

confidence: 99%

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Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility

Zhou

et al. 2021

Journal of Immunology Research

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“…Gene mutations, such as SNP, have been shown to affect cancer susceptibility in recent years ( 70 ). Japanese scholars performed genome-wide control studies of five gynecological diseases using data from 46 837 subjects (5236 fibroids, 645 endometriosis, 647 OC, 909 endometrial cancer, 538 CC, and 39 556 shared female controls) from the Japanese biobank project.…”

Section: Cervical Cancermentioning

confidence: 99%

SOX9: Advances in Gynecological Malignancies

Chen

Wen

et al. 2021

Front. Oncol.

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Transcription factors of the SOX family were first discovered in mammals in 1990. The sex-determining region Y box 9 belongs to the SOX transcription factor family. It plays an important role in inducing tissue and cell morphogenesis, survival, and many developmental processes. Furthermore, it has been shown to be an oncogene in many tumors. Gynecological malignancies are tumors that occur in the female reproductive system and seriously threaten the lives of patients. Common gynecological malignancies include ovarian cancer, cervical cancer, and endometrial cancer. So far, the molecular mechanisms related to the incidence and development of gynecological malignancies remain unclear. This makes it particularly important to discover their common causative molecule and thus provide an effective therapeutic target. In recent years, studies have found that multiple mechanisms are involved in regulating the expression of the sex-determining region Y box 9, leading to the occurrence and development of gynecological malignancies. In this review, we discuss the prognostic value of SOX9 expression and the potential of targeting SOX9 for gynecological malignancy treatment. We also discuss progress regarding the role of SOX9 in gynecological malignancy pathogenesis through its mediation of important mechanisms, including tumor initiation and proliferation, apoptosis, migration, invasion, chemoresistance, and stem cell maintenance.

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NUPR1 imparts oncogenic potential in bladder cancer

et al. 2022

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Background NUPR1, or p8, is a small chromatin protein that plays a central role in the resistance to treatment and progression of cancer. Nevertheless, the molecular mechanism of NUPR1 in bladder cancer (BLCA) remains unclear. Methods We used online databases and immunohistochemistry (IHC) to explore the expression of NUPR1 in BLCA tissues and controls. Lentivirus‐mediated small interfering ribonucleic acid (siRNA) was used to knockdown the expression of NUPR1 in two human BLCA cell lines. We used an in vivo experiment to investigate the effect of NUPR1 knockdown on the growth of BLCA. Moreover, an in silico analysis was conducted to assess the differential expression profile after NUPR1 interference. The CIBERSORT algorithm was utilized to evaluate the effects of tumor‐infiltrating immune cells among BLCA patients. Results The expression of NUPR1 in BLCA tissues was significantly higher than in the control. NUPR1 expression was also positively correlated with the stage of BLCA. After lentivirus‐mediated interference, the expression of NUPR1 was significantly down‐regulated in BLCA cell lines. The cell cycle was blocked in G1 phase and the cell proportion of S phase was decreased in both two cell lines. Moreover, in vivo experiment revealed that the tumor growth of BLCA can be delayed by inhibiting the expression of NUPR1. Both in silico analysis and functional experiments revealed that NUPR1 was correlated with epithelial–mesenchymal transition (EMT). We also revealed that macrophages were the most related immune cells associated with the expression of NUPR1 in BLCA. Conclusions This study suggests that NUPR1 plays a carcinogenic role in BLCA. NUPR1 lentivirus‐mediated interference could interfere with cycle progression of the BLCA cell, resulting in cell cycle arrest in the G1‐phase. The carcinogenic effect of NUPR1 in BLCA is likely achieved through EMT. NUPR1 is correlated with the M0‐type macrophage markers CD68 and CD11b‐integrin.

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Effects of FGFR4 G388R, V10I polymorphisms on the likelihood of cancer

Cited by 14 publications

References 38 publications

Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility

Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility

SOX9: Advances in Gynecological Malignancies

NUPR1 imparts oncogenic potential in bladder cancer

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