Effects of fetal spinal cord tissue transplants and cycling exercise on the soleus muscle in spinalized rats

Houlé, John D.; Morris, Kellie; Skinner, R.D.; García‐Rill, Edgar; Peterson, Charlotte A.

doi:10.1002/(sici)1097-4598(199907)22:7<846::aid-mus6>3.0.co;2-i

Cited by 75 publications

(79 citation statements)

References 54 publications

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“…27 Electromyographic data acquired in previous studies show that during cycling, the left and right hindlimb muscles are stretched in an alternating pattern, which results in alternating bursts of muscle activity in SCI animals. 18 Thus, cycling training also initiates sensory input to the spinal cord, and subsequently influences the firing pattern of the motoneurons that innervate the hindlimb muscles. Houle et al 18 found that cycle locomotor-trained animals showed an increase in hindlimb muscle size following SCI.…”

Section: Discussionmentioning

confidence: 99%

“…18 Thus, cycling training also initiates sensory input to the spinal cord, and subsequently influences the firing pattern of the motoneurons that innervate the hindlimb muscles. Houle et al 18 found that cycle locomotor-trained animals showed an increase in hindlimb muscle size following SCI. Additionally, cycling training has been found to normalize hyperreflexia in spinal rats 28 as well as in humans with SCI.…”

Section: Discussionmentioning

confidence: 99%

“…The design of the motor-driven cycle trainer used in these studies was adapted from the one developed by Houle et al 18 Figure 1 Outline of tibialis anterior, triceps surae, extensor digitorum and flexor digitorum muscles on a representative transaxial magnetic resonance image of the rat lower hindlimb. Data were acquired with a slice thickness of 1 mm and field of view of 2.5 Â 2.5 cm.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

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A longitudinal study of skeletal muscle following spinal cord injury and locomotor training

et al. 2008

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Study design: Experimental rat model of spinal cord contusion injury (contusion SCI).Objective: The objectives of this study were (1) to characterize the longitudinal changes in rat lower hindlimb muscle morphology following contusion SCI by using magnetic resonance imaging and (2) to determine the therapeutic potential of two types of locomotor training, treadmill and cycling. Setting: University research setting. Methods: After moderate midthoracic contusion SCI, Sprague-Dawley rats were assigned to either treadmill training, cycle training or an untrained group. Lower hindlimb muscle size was examined prior to SCI and at 1-, 2-, 4-, 8-, and 12-week post injury. Results: Following contusion SCI, we observed significant atrophy in all rat hindlimb muscles with the posterior muscles (triceps surae and flexor digitorum) showing greater atrophy than the anterior muscles (tibialis anterior and extensor digitorum). The greatest amount of atrophy was measured at 2-week post injury (range from 11 to 26%), and spontaneous recovery in muscle size was observed by 4 weeks post-SCI. Both cycling and treadmill training halted the atrophic process and accelerated the rate of recovery. The therapeutic influence of both training interventions was observed within 1 week of training and no significant difference was noted between the two interventions, except in the tibialis anterior muscle. Finally, a positive correlation was found between locomotor functional scores and hindlimb muscle size following SCI. Conclusions: Both treadmill and cycle training diminish the extent of atrophy and facilitate muscle plasticity after contusion SCI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

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A longitudinal study of skeletal muscle following spinal cord injury and locomotor training

et al. 2008

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“…MBET induces alternating contractions (via stretch reflexes) of antagonists in the same limb and agonists in different limbs, as previously reported. 39 We assume that the cycling motion elicited by MBET provides recurrent signaling that modifies this hyper-reactive circuitry, thereby leading to a restitution of low frequency-dependent depression of the H-reflex.…”

Section: Discussionmentioning

confidence: 99%

Restoration of frequency-dependent depression of the H-reflex by passive exercise in spinal rats

et al. 2005

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“…Cycle training has been used extensively in SCI rehabilitation and details are available elsewhere (Houle et al 1999.…”

Section: Passive Hind-limb Cyclingmentioning

confidence: 99%

Evaluating cardiovascular dysfunction during increased activity and exercise rehabilitation following incomplete thoracic spinal cord injury in the adult rat.

Harman¹

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Effects of fetal spinal cord tissue transplants and cycling exercise on the soleus muscle in spinalized rats

Cited by 75 publications

References 54 publications

A longitudinal study of skeletal muscle following spinal cord injury and locomotor training

A longitudinal study of skeletal muscle following spinal cord injury and locomotor training

Restoration of frequency-dependent depression of the H-reflex by passive exercise in spinal rats

Evaluating cardiovascular dysfunction during increased activity and exercise rehabilitation following incomplete thoracic spinal cord injury in the adult rat.

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