Effects of fetal hypothyroidism on uterine smooth muscle contraction and structure of offspring rats

Bagheripuor, Fatemeh; Ghanbari, Mahboubeh; Piryaei, Abbas; Ghasemi, Asghar

doi:10.1113/ep086564

Cited by 13 publications

(8 citation statements)

References 39 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fetal thyroid milieu may play a role in initiating and maintaining uterine contractions during delivery in response to endogenous oxytocin. Fetal hypothyroidism had been found to reduce uterine contractions (amplitude and frequency) in response to oxytocin administration in rat mothers 24 . Another animal study linking oxytocin administration during delivery and maternal thyroid function reported that administration of intravenous oxytocin to rats decreased their TSH, FT4, and FT3 levels 25 .…”

Section: Discussionmentioning

confidence: 99%

Congenital Hypothyroidism Can Dictate the Mode of Delivery and Intra-Labor Medication Usage

Rosen

Lavie

Yackobovitch‐Gavan

et al. 2021

Thyroid

View full text Add to dashboard Cite

Pregnancy and parturition reflect the complex interaction between physiologic conditions of the mother and her offspring, and fetal health characteristics may affect maternal health throughout pregnancy and delivery. We investigated the characteristics of the mother-infant dyad of term infants detected by the National Newborn Screening Program as having congenital hypothyroidism (CH) (131 out of 108,717; 0.12%). Three years of surveillance in our Pediatric Endocrine Clinic revealed that 65 had transient CH and 66 had permanent CH.A higher proportion of deliveries of CH infants required vacuum assistance, and more infants with CH were born through a cesarean section compared to the general population (p<0.001).Medication during labor also differed, with higher rates of oxytocin (p<0.001) and antibiotics (p=0.008) administered to mothers of CH infants. A multivariate logistic regression model revealed an increased demand for oxytocin administration during the labor of a CH infant in a hypothyroidism severity-dependent manner, expressed as a threefold risk associated with permanent but not transient CH. Our findings of increased utilization of medical interventions during the labor and delivery of CH infants suggest that the prenatal fetal thyroid function affects the development and progress of labor and delivery, in response to oxytocin.

show abstract

Section: Discussionmentioning

confidence: 99%

Congenital Hypothyroidism Can Dictate the Mode of Delivery and Intra-Labor Medication Usage

Rosen

Lavie

Yackobovitch‐Gavan

et al. 2021

Thyroid

View full text Add to dashboard Cite

show abstract

“…In an animal model, hypothyroidism increased the threshold pressure of the bladder 17 . It has been demonstrated that the amplitude and frequency of uterine smooth muscle contractions in hypothyroid rats were significantly lower than in the control group 20 . Moreover, hypothyroidism has been related to the decreased function of the parasympathetic system as shown by analyzing R‐R intervals from electrocardiograms 21 .…”

Section: Discussionmentioning

confidence: 99%

“…17 It has been demonstrated that the amplitude and frequency of uterine smooth muscle contractions in hypothyroid rats were significantly lower than in the control group. 20 Moreover, hypothyroidism has been related to the decreased function of the parasympathetic system as shown by analyzing R-R intervals from electrocardiograms. 21 As a result, it seems that hypothyroidism can alleviate storage symptoms through an anticholinergic-like effect.…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism is prevalent among adult women with chronic lower urinary tract symptoms

Zargham

Hajian

Alizadeh

et al. 2022

LUTS

View full text Add to dashboard Cite

Objective: To define the prevalence of hypothyroidism in women with chronic lower urinary tract symptoms (LUTS) and to compare the severity of each symptom between patients with hypothyroidism and controls. Subjects and methods:In this prospective observational study, we screened all adult women who came to the urology clinic between March 2017 and September 2020, and enrolled patients with chronic LUTS in the study. We assessed thyroid function.We evaluated the severity of voiding and storage urinary symptoms by the International Prostate Symptom Score. We also assessed the severity of urge urinary incontinence (UUI) and stress urinary incontinence (SUI). For between-group analysis, we selected age-matched cases and controls and compared them regarding the distribution and severity of urinary symptoms.Results: Seven hundred and twenty-five women with a mean age of 51.7 ± 14.0 years were included in the final analysis. Two hundred fifty-eight patients (35.6%) had hypothyroidism. Age-matched case and control groups consisting of 210 patients each were selected. There was no significant difference in the severity and distribution of voiding LUTS and UUI between the study groups (P values >0.05).The severity of storage symptoms was lower in patients with hypothyroidism (P = 0.04). Sixty-seven patients with hypothyroidism (31.9%) had SUI, which was significantly higher than controls (23.3%) (P = 0.03).Conclusion: More than one-third of women with chronic LUTS have hypothyroidism which is much more frequent than in the general population. We also suggest a possible relationship between hypothyroidism and the severity of SUI and an inverse relationship between hypothyroidism and storage symptoms.

show abstract

“…Moreover, thyroid hormones triiodothyronine (T3) and thyroxine (T4) are critical for normal development, growth and metabolic homeostasis [ 27 ]. Besides, thyroid hormone deficiency during pregnancy was reported in rat, which caused a decrease of litter size [ 28 ]. GnRH signaling pathway, and Ovarian steroidogenesis are classical signaling pathways related to follicle development.…”

Section: Discussionmentioning

confidence: 99%

Using High-Density SNP Array to Reveal Selection Signatures Related to Prolificacy in Chinese and Kazakhstan Sheep Breeds

Wang

Niu

Zeng

et al. 2020

Animals

View full text Add to dashboard Cite

Selection signature provides an efficient tool to explore genes related to traits of interest. In this study, 176 ewes from one Chinese uniparous breed and three Kazakhstan multiparous breeds are genotyped using Affymetrix 600K HD single nucleotide polymorphism (SNP) arrays, F-statistics (Fst), and a Cross Population Extend Haplotype Homozygosity Test (XPEHH). These are conducted to identify genomic regions that might be under selection in three population pairs comprised the one multiparous breed and the uniparous breed. A total of 177 and 3072 common selective signatures were identified by Fst and XPEHH test, respectively. Nearly half of the common signatures detected by Fst were also captured by XPEHH test. In addition, 1337 positive and 1735 common negative signatures were observed by XPEHH in three Kazakhstan multiparous breeds. In total, 242 and 798 genes were identified in selective regions and positive selective regions identified by Fst and XPEHH, respectively. These genes were further clustered in 50 gene ontology (GO) functional terms and 66 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in enrichment analysis. The GO terms and pathways were relevant with reproductive processes, e.g., oxytocin signaling pathway, thyroid hormone synthesis and GnRH signaling pathway, vascular smooth muscle contraction and lipid metabolism (alpha-Linolenic acid metabolism and Linoleic acid metabolism), etc. Based on the findings, six potential candidate genes ESR1, OXTR, MAPK1, RYR1, PDIA4, and CYP19A1, under positive selection related to characteristics of multiparous sheep breeds were revealed. Our results improve our understanding of the mechanisms of selection that underlies the prolificacy trait in sheep, and provide essential references for future sheep breeding.

show abstract

Effects of fetal hypothyroidism on uterine smooth muscle contraction and structure of offspring rats

Cited by 13 publications

References 39 publications

Congenital Hypothyroidism Can Dictate the Mode of Delivery and Intra-Labor Medication Usage

Congenital Hypothyroidism Can Dictate the Mode of Delivery and Intra-Labor Medication Usage

Hypothyroidism is prevalent among adult women with chronic lower urinary tract symptoms

Using High-Density SNP Array to Reveal Selection Signatures Related to Prolificacy in Chinese and Kazakhstan Sheep Breeds

Contact Info

Product

Resources

About